Chest, 2012 Vaccination and antimicrobial therapy remain the cornerstones of the management of pneumococcal pneumonia. Despite significant successes, the capacity of the pneumococcus to evolve in the face of the selective pressure of anticapsular immunity challenges immunization programs.
David H. Dockrell +2 more
openaire +3 more sources
Indirect effect of 7-valent and 13-valent pneumococcal conjugated vaccines on pneumococcal pneumonia hospitalizations in elderly [PDF]
, 2018 Background: Pneumonia is one of the leading causes of mortality and has a high burden in morbidity. In Portugal, 7-valent pneumococcal conjugated vaccine (PCV) was used since 2001 and PCV10/13 since 2009, being the last introduced into the National ...
Froes, Filipe +6 more
core +2 more sources
Epithelial cell–derived secreted and transmembrane 1a signals to activated neutrophils during pneumococcal pneumonia [PDF]
, 2016 Airway epithelial cell responses are critical to the outcome of lung infection. In this study, we aimed to identify unique contributions of epithelial cells during lung infection.
Belkina, Anna C. +12 more
core +1 more source
Vaccines, 2022 Streptococcus pneumoniae infection is responsible for significant morbidity and mortality, particularly in young children and older adults. The aim of this study was to investigate the incidence of hospitalisation and emergency department (ED) visits in ...
Matteo Astengo +10 more
doaj +1 more source
Impact of Pneumococcal Conjugate Vaccines on Pneumonia Hospitalizations in High- and Low-Income Subpopulations in Brazil. [PDF]
, 2017 BackgroundPneumococcal conjugate vaccines (PCVs) are being used worldwide. A key question is whether the impact of PCVs on pneumonia is similar in low- and high-income populations.
Kürüm, Esra +7 more
core +2 more sources
Animal Models of Pneumococcal pneumonia [PDF]
International Journal of Molecular Sciences, 2019 Streptococcus pneumoniae remains the most common bacterial pathogen causing lower respiratory tract infections and is a leading cause of morbidity and mortality worldwide, especially in children and the elderly. Another important aspect related to pneumococcal infections is the persistent rate of penicillin and macrolide resistance.
Marcos I. Restrepo +3 more
openaire +3 more sources
Human Vaccines & Immunotherapeutics, 2020 Since the early 2000s, pneumococcal conjugate vaccines (PCVs) have been shown to be effective in the prevention of pneumonia and invasive pneumococcal diseases.
I. Rivero-Calle +7 more
doaj +1 more source
Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system. [PDF]
, 2012 Routine use of pneumococcal conjugate vaccines (PCVs) in developing countries is expected to lead to a significant reduction in childhood deaths. However, PCVs have been associated with replacement disease with non-vaccine serotypes.
Adegbola, Richard A +18 more
core +2 more sources
Pneumococcus and the stress-gradient hypothesis: a trade-off links $R_0$ and susceptibility to co-colonization across countries [PDF]
arXiv, 2022 Modern molecular technologies have revolutionized our understanding of bacterial epidemiology, but reported data across different settings remain under-integrated in common theoretical frameworks. Pneumococcus serotype co-colonization, caused by the polymorphic bacteria Streptococcus pneumoniae, has been increasingly investigated in recent years. While
arxiv
Improving performance of CNN to predict likelihood of COVID-19 using chest X-ray images with preprocessing algorithms [PDF]
International Journal of Medical Informatics, 104284. 23 Sep. 2020, 2020 As the rapid spread of coronavirus disease (COVID-19) worldwide, chest X-ray radiography has also been used to detect COVID-19 infected pneumonia and assess its severity or monitor its prognosis in the hospitals due to its low cost, low radiation dose, and wide accessibility.
arxiv +1 more source