Results 91 to 100 of about 27,990 (228)

Expert Consensus on the Diagnosis and Monitoring of Paroxysmal Nocturnal Hemoglobinuria (PNH): An Algorithmic Approach in an Era of New Treatments

European Journal of Haematology, EarlyView.
ABSTRACT Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder caused by a defect of glycosylphosphatidyl‐anchored proteins, leading to an uncontrolled complement‐mediated hemolysis. The advent of complement inhibitors in clinical practice radically changed patients' outcomes and survival.
Bruno Fattizzo, Monia Marchetti, Elisa Cannizzo, Arianna Gatti, Massimo Geuna, Anna Paola Iori, Maddalena Raia, Simona Sica, Francesco Buccisano   +8 more
wiley   +1 more source

A 3’UTR-derived small RNA represses pneumolysin synthesis and facilitates pneumococcal brain invasion

Communications Biology
Pneumolysin (Ply) of Streptococcus pneumoniae (pneumococcus) at relatively high and low levels facilitates pneumococcal invasion into the lung and brain, respectively; however, the regulatory mechanisms of Ply expression are poorly understood.
Kaiqiang Shen, Wenshuang Miao, Lin Zhu, Qingqing Hu, Fu Ren, Xiuzhu Dong, Huichun Tong   +6 more
doaj   +1 more source

Protein conjugate polysaccharide vaccines: Challenges in development and global implementation

Indian Journal of Community Medicine, 2012
Pneumonia and meningitis caused by Haemophilus influenzae type b, Streptococcus pneumoniae, and Neisseria meningitidis are among the leading causes of under five mortality and morbidity.
Manisha Nair
doaj   +1 more source

PNEUMOCOCCUS INFECTION AND IMMUNITY [PDF]

Journal of the American Medical Association, 1912
During the past few years there has occurred a revival of interest in the study of the nature of infection with the pneumococcus. It will be impossible to review all the discoveries of interest and importance that have been made. The intention is to confine the present discussion mainly to certain observations made by my colleagues and associates and ...
openaire   +2 more sources

Would patients over 65 years of age accept vaccination while hospitalised? An assessment of eligibility and acceptability

Internal Medicine Journal, EarlyView.
Abstract Background Vaccination is effective at preventing severe illness related to influenza, pneumococcal disease and coronavirus disease 2019 COVID‐19. Vaccine coverage among older Australians is incomplete, and hospitals currently administer very few vaccine doses.
Victoria Deacon, Kristen Overton, Parthsinh Solanki, Ethan MacMinn, Anthea L. Katelaris, Jeffrey J. Post   +5 more
wiley   +1 more source

A Novel Function for the Streptococcus pneumoniae Aminopeptidase N: Inhibition of T Cell Effector Function through Regulation of TCR Signaling

Frontiers in Immunology, 2017
Streptococcus pneumoniae (Spn) causes a variety of disease states including fatal bacterial pneumonia. Our previous finding that introduction of Spn into an animal with ongoing influenza virus infection resulted in a CD8+ T cell population with reduced ...
Lance K. Blevins, Derek Parsonage, Melissa B. Oliver, Elizabeth Domzalski, W. Edward Swords, Martha A. Alexander-Miller   +5 more
doaj   +1 more source

A STUDY OF PNEUMOCOCCUS CARRIERS [PDF]

Archives of Internal Medicine, 1919
During the winter of 1917-1918, 1,311 cases of pneumonia were treated at the Base Hospital, Camp Wheeler, Ga., with 275 deaths, constituting the largest mortality of any single disease in the camp, indeed, more than 80 per cent. of all the deaths that occurred.
openaire   +2 more sources

Will Extended‐Valency Pneumococcal Conjugate Vaccines Offer Enhanced Coverage Against Invasive Pneumococcal Disease for At‐Risk Children?

Acta Paediatrica, EarlyView.
Robert Cohen, Corinne Levy, Naim Ouldali, Stéphane Béchet, Aude Estivaux, André Birgy, Isabelle Hau, IPD Study Group, Emmanuelle Varon   +8 more
wiley   +1 more source

Preventing infections after CD19‐directed chimeric antigen receptor T‐cell therapies for lymphoma: a consensus practice statement

Internal Medicine Journal, EarlyView.
Abstract Chimeric antigen receptor (CAR) T‐cell therapies directed against cluster of differentiation 19 (CD19) are a standard of care for relapsed or refractory B‐cell lymphomas. Infection is the leading cause of non‐relapse mortality, and this risk may persist for years after CAR T‐cell receipt.
Aine Hurley, Philip George, Gemma Reynolds, Adam Stewart, Hang Quach, Nicole O'Leary, Zoe McQuilten, Andrea S. Henden, Lynette Chee, Chan Y. Cheah, Olivia Bupha‐Intr, Emily Blyth, Ben Teh, Monica Slavin, Michael Dickinson, Robert Weinkove   +15 more
wiley   +1 more source

STUDIES ON THE PNEUMOCOCCUS [PDF]

Journal of Experimental Medicine, 1905
C W, Duval, P A, Lewis
openaire   +2 more sources