Results 51 to 60 of about 27,990 (228)

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Etiological role and molecular-genetic features of Streptococcus pneumoniae in children’s infectious diseases

Детские инфекции (Москва), 2020
Objective: To study the etiological role, serotype distribution and prevalent Streptococcus pneumoniae genotypes (sequence types) in 459 children hospitalized with acute purulent otitis media, acute tonsillitis, community-acquired pneumonia, and purulent
I. N. Protasova, G. P. Martynova, N. A. Ilyenkova, I. A. Kutischeva, S. V. Domracheva, O. P. Ovchinnikova, E. S. Sokolovskaya   +6 more
doaj   +1 more source

In‐line Raman spectroscopy real‐time glucose prediction method for commercial pneumococcal vaccine drug substance fermentation manufacturing process control

Biotechnology Progress, EarlyView.
Abstract Traditional off‐line analysis methods to quantify residual metabolite concentrations in a drug substance fermentation process consume valuable time, require costly resources, and demand potentially hazardous manual operations when working with pathogenic biological organisms.
Griffin P. Thomas, Brian C. Marks, Barbara B. Alvarado‐Hernandez, Matthew Woodling, James O'Connor, Roberto Ortiz, John Higgins, Jon Shanter   +7 more
wiley   +1 more source

THE DISINFECTION OF PNEUMOCOCCUS CARRIERS [PDF]

JAMA: The Journal of the American Medical Association, 1918
Recent studies on the epidemiology of lobar pneumonia by Dochez and Avery, 1 Stillman, 2 and Sydenstricker and Sutton 3 have shown, in a considerable proportion of cases, that this disease arises by infection from without, because of the entrance into the upper air passages of virulent pneumococci of the fixed serologic types, contracted from persons ...
openaire   +1 more source

High levels of recombination among Streptococcus pneumoniae isolates from the Gambia. [PDF]

, 2011
We carried out multilocus sequence typing (MLST) on 148 pneumococcal carriage isolates collected from children
Bishop, CJ, Donkor, ES, Wren, B, C. J. Bishop, M. Antonio, K. A. Gould, Hanage, WP, W. P. Hanage, Hinds, J, Antonio, M, E. S. Donkor, Gould, KA, J. Hinds, Gould, K, B. Wren   +14 more
core   +1 more source

Enhancing Evidence Generation by Linking Randomized Clinical Trials to Real‐World Data: The INVESTED‐Medicare Linkage Study

Clinical Pharmacology &Therapeutics, EarlyView.
Real‐world evidence (RWE) derived from real‐world data (RWD) can complement randomized controlled trials (RCTs), yet the validity of RWD relative to RCT data remains insufficiently characterized. We obtained post hoc consent and linked individual participant data from the US‐based INVESTED trial (2016–2019) with Medicare fee‐for‐service claims (2012 ...
Hanseul Cho, HoJin Shin, Mehdi Najafzadeh, Brian Claggett, Janinne Ortega‐Montiel, Jun Liu, Julie M. Paik, Narlina F. Lalani, Marie C. Bradley, John Concato, Scott D. Solomon, Orly Vardeny, Elisabetta Patorno   +12 more
wiley   +1 more source

A low-cost culture- and DNA extraction-free method for the molecular detection of pneumococcal carriage in saliva

Microbiology Spectrum
Molecular methods have improved the sensitivity of the detection of pneumococcal carriage in saliva. However, they typically require sample culture enrichment and nucleic acid extraction prior to performing the detection assay and may limit scalability ...
Chikondi Peno, Tzu-Yi Lin, Maikel S. Hislop, Devyn Yolda-Carr, Katherine Farjado, Anna York, Virginia E. Pitzer, Daniel M. Weinberger, Amy K. Bei, Orchid M. Allicock, Anne L. Wyllie   +10 more
doaj   +1 more source

Effect of shin'iseihaito on lung colonization of pneumococcus in murine model [PDF]

, 2015
Background: Streptococcus pneumoniae (pneumococcus) causes various serious diseases including sinusitis, pneumonia, and meningitis. One serious problem observed recently with pneumococcal therapy is attenuation of the antibiotic effect because of the ...
Toshiaki Makino, Jiang, Zhixia, Toru Konishi, Konishi, Toru, Makino, Toshiaki, Tetuya Arai, Zhixia Jiang, Arai, Tetuya, Minami, Masaaki, Arai, Tetsuya, Masaaki Minami   +10 more
core   +1 more source

Vaginal host–microbe signatures linked to placental outcomes in mares

Equine Veterinary Journal, EarlyView.
Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule, Babiche Heil, Jamie K. Norris, Kristene Gedye, Xiaoxiao Lin, Ward De Spiegelaere, Peter Daels, Pouya Dini   +7 more
wiley   +1 more source

Identification of human T-cell antigens in pneumococcus.

, 2012
Identification of human T-cell antigens in pneumococcus.
Nicholas Croucher (120844), Richard Malley (23233), Todd Gierahn (120838), Yuan Li (67017), Claudette M. Thompson (23230), Jessica B. Flechtner (120848), Krzysztof Trzciński (4391362), Christopher B. Ford (120842), Paulo Gouveia (120846), Marc Lipsitch (14729)   +9 more
core   +1 more source