Results 71 to 80 of about 22,008 (204)

The Epidemiology of Sickle Cell Disease in Sub‐Saharan Africa: Current Knowledge and Gaps to be Filled

American Journal of Hematology, Volume 101, Issue S1, Page 5-16, April 2026.
What are the available data on incidence & prevalence prognosis risk factors of severity of sickle cell disease in sub‐Saharan Africa? ABSTRACT Sickle Cell Disease (SCD) is highly prevalent in sub‐Saharan Africa. Epidemiological data remain sparse, but regional screening and research initiatives are expanding.
Brigitte Ranque, Leon Tshilolo, Thomas N. Williams   +2 more
wiley   +1 more source

CLARYTROMYCIN IN TREATMENT OF PEDIATRIC ACUTE RESPIRATORY DISEASES

Вопросы современной педиатрии, 2012
Acute respiratory diseases still occupy leading positions among all pediatric diseases. This article contains modern data upon etiology of acute and recurrent bronchitides, as well as that of out-of-hospital pneumonias in children.
A. Yu. Simonova
doaj   +1 more source

Antimicrobial Effect of Spices and Their Phytochemicals: A Novel Approach to Overcoming Antibiotic Resistance

MedComm, Volume 7, Issue 4, -Not available-.
This graphical abstract shows the antibacterial potential of phytochemicals from 15 spices, showcasing key compounds, their extraction methods, and mechanisms of action. It highlights membrane disruption, ROS generation, enzyme inhibition, and biofilm prevention as core antibacterial pathways.
Hettiyahandi Binodh De Silva, Yanqi Dai, Shervanthi Homer‐Vanniasinkam, Mohan Edirisinghe   +3 more
wiley   +1 more source

Evaluating methods for identifying and quantifying Streptococcus pneumoniae co-colonization using next-generation sequencing data

Microbiology Spectrum
Detection of multiple pneumococcal serotype carriage can enhance monitoring of pneumococcal vaccine impact, particularly among high-burden childhood populations.
Jada Hackman, Martin L. Hibberd, Todd D. Swarthout, Jason Hinds, James Ashall, Carmen Sheppard, Gerry Tonkin-Hill, Kate Gould, Comfort Brown, Jacquline Msefula, Andrew A. Mataya, Michiko Toizumi, Lay-Myint Yoshida, Neil French, Robert S. Heyderman, Stefan Flasche, Brenda Kwambana, Stéphane Hué   +17 more
doaj   +1 more source

Sutimlimab in Patients With Cold Agglutinin Disease (CAD): Results From a Managed Access Program

European Journal of Haematology, Volume 116, Issue 4, Page 409-415, April 2026.
ABSTRACT Cold agglutinin disease (CAD) is a low‐grade lymphoproliferative disorder accounting for 15%–30% of patients suffering from autoimmune hemolytic anemias. The clonal B cells produce autoantibodies primarily of the IgM‐κ class that cause agglutination of red blood cells (RBCs) at temperatures ≤ 37°C and activate the classical complement pathway ...
Sandra Maria Frey, Pauline Halberstadt, Ferras Alashkar, Veronika Lenz, H. Christian Reinhardt, Alexander Röth   +5 more
wiley   +1 more source

Cysteine-mediated gene expression and characterization of the CmbR regulon in Streptococcus pneumoniae

Frontiers in Microbiology, 2016
In this study, we investigated the transcriptomic response of Streptococcus pneumoniae D39 to cysteine. Transcriptome comparison of the D39 wild-type strain grown at a restricted concentration of cysteine (0.03 mM) to one grown at a high concentration of
Muhammad Afzal, Muhammad Afzal, Irfan Manzoor, Irfan Manzoor, Oscar P. Kuipers, Sulman Shafeeq   +5 more
doaj   +1 more source

Factors Affecting Immune Reconstitution Post‐Allogeneic HSCT in Children: The Case for an Individualized Approach to Vaccination

European Journal of Haematology, Volume 116, Issue 4, Page 336-349, April 2026.
ABSTRACT Allogeneic hematopoietic stem cell transplantation (HSCT) is increasingly used to treat malignant and non‐malignant diseases. Following allogeneic HSCT, patients are particularly vulnerable to vaccine‐preventable diseases (VPD) because conditioning depletes immune cells, including memory cells.
Hélène Buvelot, Frederic Baleydier, Laure Pittet, Geraldine Blanchard‐Rohner   +3 more
wiley   +1 more source

Risdiplam Impact in Treatment Naïve and Non‐Naïve Pediatric and Adult Patients With Spinal Muscular Atrophy

European Journal of Neurology, Volume 33, Issue 4, April 2026.
This 36‐month prospective study of 34 symptomatic SMA patients (ages 6.9–50.9 years) found significant motor and quality of life improvements with risdiplam treatment. Treatment‐naïve patients showed notable gains in MFM‐32 and RULM scores, while those switching therapies improved in MFM‐32.
Pak On Patrick Yee, Hayley Hoi Ning Ip, Michael Kwan Leung Yu, Pui Kei Cheng, Wilfred Hing Sang Wong, Patrick Pak Hei Ng, Nathan Sheung Tat Kwong, Priscillia Lam, Mei Wun Cheung, Angel Tung, Stephen Chan, Shirley Ng, Wai Lan Yeung, Sheila Wong, Yuen Gao, Shirley Pang, Sophelia Hoi Shan Chan   +16 more
wiley   +1 more source

Preventing First and Further Decompensation in Advanced Chronic Liver Disease

Liver International, Volume 46, Issue 4, April 2026.
ABSTRACT Advanced chronic liver disease (ACLD) remains a major cause of global morbidity and mortality. Preventing hepatic decompensation—both the first event and subsequent recurrences—has become a central therapeutic goal to prolong survival. The transition from the compensated phase (cACLD) to the decompensated phase (dACLD) is driven by clinically ...
Leonardo Corrêa Süffert, Bernardo de Faria Moraes, Guilherme Grossi Lopes Cançado   +2 more
wiley   +1 more source

Herpes Zoster Vaccine Uptake Among United States Adults With Rheumatic Disease: A Mixed‐Methods Analysis

ACR Open Rheumatology, Volume 8, Issue 3, March 2026.
Objective Adults with rheumatic diseases are at increased risk for herpes zoster (HZ). Recommendations for the recombinant zoster vaccine (RZV) were expanded in 2021 to include those aged ≥19 years at increased risk for HZ due to immunodeficiency or immunosuppression because of disease or therapy, but the impact of these expanded recommendations is ...
Justin Carrico, Catherine McGuiness, Marie Yasuda, Chi‐Chang Chen, Vasudha Gupta, Rita Campos, Nikita Stempniewicz, Justin Gatwood   +7 more
wiley   +1 more source