Results 91 to 100 of about 20,881 (221)

Treosulfan–fludarabine conditioning in infants with severe combined immunodeficiencies: Extended study of the UK paediatric treosulfan study

British Journal of Haematology, Volume 208, Issue 5, Page 1713-1723, May 2026.
Summary Allogeneic haematopoietic stem cell transplantation (HSCT) is a curative therapy for severe combined immunodeficiency (SCID). Conditioning improves donor engraftment and freedom from immunoglobulin replacement (IgR) but increases the risks of acute and late toxicity. Treosulfan, a reduced toxicity alkylating agent, has emerged as an alternative
Su Han Lum, Sinéad Greener, Irum Latif Memon, Persis Amrolia, Zohreh Nademi, Robert Chiesa, Juliana Silva, Helen Young, Stephen Owens, Eleri Williams, Khuen Foong Ng, Terry Flood, Andrew R Gennery, Sophie Hambleton, Kanchan Rao, Mary Slatter   +15 more
wiley   +1 more source

New Short Tandem Repeat-Based Molecular Typing Method for Pneumocystis jirovecii Reveals Intrahospital Transmission between Patients from Different Wards.

PLoS ONE, 2015
Pneumocystis pneumonia is a severe opportunistic infection in immunocompromised patients caused by the unusual fungus Pneumocystis jirovecii. Transmission is airborne, with both immunocompromised and immunocompetent individuals acting as a reservoir for ...
Maud Gits-Muselli, Marie-Noelle Peraldi, Nathalie de Castro, Véronique Delcey, Jean Menotti, Nicolas Guigue, Samia Hamane, Emmanuel Raffoux, Anne Bergeron, Sandrine Valade, Jean-Michel Molina, Stéphane Bretagne, Alexandre Alanio   +12 more
doaj   +1 more source

Epidemiological Characteristics and Co‐Detection Patterns of Rhinovirus (A/B/C) and Influenza A Virus in a Regional Respiratory Cohort in Hunan, China

The Clinical Respiratory Journal, Volume 20, Issue 5, May 2026.
This study analyzed 386 rhinovirus infections (dominant Type A, 60.9%; high 73.1% coinfection rate) and Influenza A interactions. Rhinovirus A/B showed mutual exclusivity with Influenza A, while Type C had near‐random association, with temporal prevalence fluctuations observed. ABSTRACT Objective To characterize the epidemiological profile, coinfection
Feicheng Yang, Ping Bai, Jiaxuan Zhang, Juqi Peng, Qing Hu, Yanchun Li   +5 more
wiley   +1 more source

Designing an mRNA Vaccine against P. jirovecii Involved in Fatal Pneumonia Infections via Comparative Proteomics and Reverse Vaccinology Approaches

Frontiers in Bioscience-Landmark
Background: Pneumocystis jirovecii is the most emerging life-threating health problem that causes acute and fatal pneumonia infection. It is rare and more contagious for patients with leukemia and immune-deficiency disorders.
Muhammad Naveed, Khizra Jabeen, Tariq Aziz, Muhammad Saad Mughal, Hammad Arif, Metab Alharbi, Thamer H Albakeiri, Abdullah F. Alasmari   +7 more
doaj   +1 more source

Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance

Emerging Infectious Diseases, 2004
Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sulfa drugs, trimethoprim-sulfamethoxazole (TMP-SMX) and dapsone are mainstays of PCP treatment and prophylaxis.
Laurence Huang, Kristina Crothers, Chiara Atzori, Thomas Benfield, Robert Miller, Meja Rabodonirina, Jannik Helweg-Larsen   +6 more
doaj   +1 more source

Invasive Fungal Infections After Intestine Transplantation: Epidemiology and Outcomes

Mycoses, Volume 69, Issue 5, May 2026.
ABSTRACT Background Invasive fungal infections (IFIs) represent a major complication after intestine transplantation, with reported incidence rates between 40% and 49%. These infections are associated with high morbidity and allograft loss. This study evaluates the impact of post‐transplant IFIs on graft outcomes in intestine transplant recipients ...
Mayyadah H. Alabdely, Jessica Lum, Blanca E. Gonzalez, Masato Fujiki, Zachary A. Yetmar   +4 more
wiley   +1 more source

Isolated Kidney Transplant in Primary Hyperoxaluria‐1 Enabled by Small Interfering RNA (siRNA) Therapy. Is It Time for Change? Case Report and Review of the Literature

Pediatric Transplantation, Volume 30, Issue 5, May 2026.
ABSTRACT Background Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder characterized by excessive oxalate production that leads to nephrocalcinosis or nephrolithiasis and progressive kidney failure, associated with systemic oxalosis that is not reversed by dialysis. Pharmacological treatment is limited.
Shameer M. Habeeb, Eva Simkova, Samhar Al‐Akash, Hazem S. Awad, Haneen Yamin, Loai A. Eid, Watfa S. Aldhaheri, Waldo Concepcion, Martin Bitzan   +8 more
wiley   +1 more source

Antibody Responses against Pneumocystis jirovecii in Health Care Workers Over Time

Emerging Infectious Diseases, 2013
In a previous cross-sectional study, we showed that clinical staff working in a hospital had significantly higher antibody levels than nonclinical staff to Pneumocystis jirovecii.
Serena Fong, Kieran R. Daly, Renuka Tipirneni, Leah G. Jarlsberg, Kpandja Djawe, Judy V. Koch, Alexandra Swartzman, Brenna Roth, Peter D. Walzer, Laurence Huang   +9 more
doaj   +1 more source

Pneumocystis jirovecii Frenkel

, 2018
P. jirovecii prevalence and patients ’ characteristics Among all renal transplant recipients tested (n = 72, including 36 males, 36 females), the mean age was 52.5 ± 13.9 years, range 21–76 years. The mean time after kidney transplantation was 78.7 months, ranging from 5 days to 19 years.
Szydłowicz, Magdalena, Jakuszko, Katarzyna, Szymczak, Anna, Piesiak, Paweł, Kowal, Aneta, Kopacz, Żaneta, Wesołowska, Maria, Lobo, Maria Luísa, Matos, Olga, Hendrich, Andrzej B., Kicia, Marta   +10 more
openaire   +2 more sources

آيا شيوع کلونيزاسيون با پنوموسيستيس جيرووسی در مبتلايان به بيماری انسدادی مزمن ريوی با شرايط اکولوژيک و اقليمی ارتباط دارد؟ [PDF]

, 2014
زمينه و هدف : بيماری انسدادی مزمن ريوی (COPD) از علل شايع مرگ و مير می باشد. نقش عوامل عفونی در ايجاد و تشديد اين بيماری مشخص شده است. پنوسيستيس جيرووسی قارچ فرصت طلبی است که در افراد دارای نقص سيستم ايمنی منجر به پنومونی می شود.
ثمره فکری, میترا, حسن آقائی, ترلان, غلامرضاپور, محمدرضا, ملائی, حمیدرضا, هاشمی باجگانی, سید مهدی, یزدانی, رستم   +5 more
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