Results 71 to 80 of about 22,573 (206)

The Power of Hematopoietic Stem Cell Transplantation (HSCT): A Curative Approach for Diffuse Large B‐Cell Lymphoma (DLBCL) Incidentally Detected in a SCID Baby

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Lymphoma is a rare complication of X‐linked severe combined immunodeficiency (X‐SCID) caused by IL2RG deficiency. We report an infant with IL2RG‐SCID who developed diffuse large B‐cell lymphoma (DLBCL) during pretransplant evaluation. A male infant with T−B+ SCID was diagnosed at 1 month of age and referred for hematopoietic stem cell ...
Burcu Sarıgül Cimi, Sule Haskologlu, Candan Islamoglu, Gokcan Ozturk, Nazlı Deveci, Hasret Erkmen, Selin Sevinc, Can Akal, Seda Kaynak Sahap, Sonay Özdemir, Suat Fitoz, Isınsu Kuzu, Emel Unal, Nurdan Tacyıldız, Figen Dogu, Aydan Ikinciogullari   +15 more
wiley   +1 more source

Pneumocystis jirovecii kann in pseudostratifizierten air-liquid-interface Zellkulturen produktiv gezüchtet werden

, 2014
Although Pneumocystis jirovecii is a well-known and serious pathogen, all previous attempts to isolate, cultivate, and propagate this fungus have failed. This serious challenge in microbiology was addressed in the present study.
Brockmann, M, Soumaya Khalfaoui, Lüsebrink, J, Mai, S, Ramona L. Tillmann, Michael Brockmann, Schildgen, O, Tillmann, RL, Stephanie Mai, Verena Schildgen, Khalfaoui, S, Jessica Lüsebrink, Oliver Schildgen, Monika Pieper, Pieper, M, Schildgen, V   +15 more
core   +1 more source

Bone Marrow Infection by Pneumocystis jirovecii in a Patient with AIDS: A Case Report and Literature Review

Infectious Disease Reports
Background: Pneumocystis jirovecii primarily causes pneumonia in immunosuppressed individuals, particularly those living with advanced HIV/AIDS. Extrapulmonary dissemination is uncommon, with bone marrow involvement described in only a handful of cases ...
Diego Alejandro Cubides-Diaz, Valentina Negrette-Lazaro, Viviana Poveda-Hurtado, Juan Pablo López-Salazar, Carlos Mauricio Calderón-Vargas, Carlos Arturo Álvarez-Moreno   +5 more
doaj   +1 more source

Cytomegalovirus in Bronchoalveolar Lavage Fluid: A Predictor of Outcome in Immunocompromised Patients

Journal of Medical Virology, Volume 98, Issue 10, October 2026.
ABSTRACT Cytomegalovirus (CMV) is a prevalent herpesvirus that remains typically asymptomatic in immunocompetent individuals but can cause severe, potentially life‐threatening disease in immunocompromised patients. This study assessed the impact of CMV‐associated lower respiratory tract infections (LRTIs), diagnosed by polymerase chain reaction (PCR ...
Theodora Zouvani, Meropi Karakioulaki, Kathleen Jahn, Sebastian Fähndrich, Björn C. Frye, Leticia Grize, Eleni Papakonstantinou, Hartmut Hengel, Karoline Leuzinger, Hans H. Hirsch, Daiana Stolz   +10 more
wiley   +1 more source

Pneumocystis jirovecii infection in patients with acute interstitial pneumonia

, 2020
[ES] Objetivo: La neumonía intersticial aguda (NIA) es una enfermedad grave de etiología desconocida. Pneumocystis jirovecii es un hongo oportunista atípico capaz de colonizar pacientes con enfermedad pulmonar crónica e inducir la activación de los ...
Horra, Carmen de la, Martínez-Risquez M. T., Medrano, Francisco Javier, Friaza Patiño, Vicente, Calderón, Enrique J., Martín-Juan, José   +5 more
core   +1 more source

All‐Oral PI3Kδ and HDAC Inhibition with Parsaclisib Plus Chidamide and Step‐Down Maintenance in Relapsed or Refractory Peripheral T‐Cell Lymphoma: A Phase Ib Trial

MedComm, Volume 7, Issue 10, October 2026.
ABSTRACT Single‐agent targeted therapies for relapsed or refractory peripheral T‐cell lymphoma (R/R peripheral T‐cell lymphoma [PTCL]) produce modest, short‐lived responses, underscoring the need for tolerable, chemotherapy‐free combinations. In an open‐label, single‐arm Phase Ib trial at two tertiary hospitals, we evaluated parsaclisib plus chidamide ...
Xufeng Luo, Zheng Yan, Wei Fang, Hanchi Duan, Qiuyu Zhang, Haiying Wang, Shuna Yao, Jiuyang Zhang, Yiping Jin, Wenyong Li, Xiaolu Teng, Lina Zhang, Lijie Liang, Quande Lin, Ping Wang, Haoran Si, Jinxin Miao, Wenping Zhou, Zhihua Yao, You‐Wen He, Qingxin Xia, Yanyan Liu   +21 more
wiley   +1 more source

The molecular diagnosis of Pneumocystis pneumonia in children using nasopharyngeal aspirate samples [PDF]

, 2011
Pneumocystis pneumonia (PCP) is an important opportunistic infection caused by thefungus Pneumocystis jirovecii. The incidence of PCP in sub-Saharan Africa is on theincrease.
Samuel, Catherine Mary
core   +1 more source

Bruton's Tyrosine Kinase Inhibitors: Mechanisms, Efficacy, Toxicities and Applications for the Treatment of Human Diseases

MedComm, Volume 7, Issue 10, October 2026.
BTK inhibitors suppress malignant B‐cell signaling while simultaneously reshaping immune regulation through effects on T cells and the tumor microenvironment. These mechanisms support combination immunotherapy strategies and also underlie the expanding application of BTK inhibitors in solid tumors, autoimmune and inflammatory diseases.
Miao Sun, Dengju Li, Jia Wei
wiley   +1 more source

Designing an mRNA Vaccine against P. jirovecii Involved in Fatal Pneumonia Infections via Comparative Proteomics and Reverse Vaccinology Approaches

Frontiers in Bioscience-Landmark
Background: Pneumocystis jirovecii is the most emerging life-threating health problem that causes acute and fatal pneumonia infection. It is rare and more contagious for patients with leukemia and immune-deficiency disorders.
Muhammad Naveed, Khizra Jabeen, Tariq Aziz, Muhammad Saad Mughal, Hammad Arif, Metab Alharbi, Thamer H Albakeiri, Abdullah F. Alasmari   +7 more
doaj   +1 more source

New Short Tandem Repeat-Based Molecular Typing Method for Pneumocystis jirovecii Reveals Intrahospital Transmission between Patients from Different Wards.

PLoS ONE, 2015
Pneumocystis pneumonia is a severe opportunistic infection in immunocompromised patients caused by the unusual fungus Pneumocystis jirovecii. Transmission is airborne, with both immunocompromised and immunocompetent individuals acting as a reservoir for ...
Maud Gits-Muselli, Marie-Noelle Peraldi, Nathalie de Castro, Véronique Delcey, Jean Menotti, Nicolas Guigue, Samia Hamane, Emmanuel Raffoux, Anne Bergeron, Sandrine Valade, Jean-Michel Molina, Stéphane Bretagne, Alexandre Alanio   +12 more
doaj   +1 more source