Results 71 to 80 of about 13,290 (176)
Comparative Genomics Suggests Primary Homothallism of
mBio, 2015 Pneumocystis species are fungal parasites of mammal lungs showing host specificity. Pneumocystis jirovecii colonizes humans and causes severe pneumonia in immunosuppressed individuals.
João M. G. C. F. Almeida +4 more
doaj +1 more source
JGH Open, Volume 10, Issue 8, August 2026.ABSTRACT Background Calcineurin inhibitors such as tacrolimus are established rescue therapies for steroid‐refractory ulcerative colitis (UC). However, their efficacy and safety as bridging or combination therapy following failure of both anti‐tumor necrosis factor (anti‐TNF) and Janus kinase (JAK) inhibitor therapy remain uncertain.
Nikil Vootukuru +5 more
wiley +1 more source
Infectious Disease ReportsBackground: Pneumocystis jirovecii primarily causes pneumonia in immunosuppressed individuals, particularly those living with advanced HIV/AIDS. Extrapulmonary dissemination is uncommon, with bone marrow involvement described in only a handful of cases ...
Diego Alejandro Cubides-Diaz +5 more
doaj +1 more source
Frontiers in Bioscience-LandmarkBackground: Pneumocystis jirovecii is the most emerging life-threating health problem that causes acute and fatal pneumonia infection. It is rare and more contagious for patients with leukemia and immune-deficiency disorders.
Muhammad Naveed +7 more
doaj +1 more source
Journal of Medical Virology, Volume 98, Issue 8, August 2026.ABSTRACT This study examined changes in anti‐Spike (anti‐S) antibodies (Abs) and type I interferon (IFN‐I) following the BNT162b2 vaccine in people living with HIV (PLWH) and analyzed the impact of demographic and immunological factors. In total, 75 PLWH and 28 healthy donors were followed at baseline (T0), at the second dose (T1), after the second ...
Federica Frasca +18 more
wiley +1 more source
PLoS ONE, 2015 Pneumocystis pneumonia is a severe opportunistic infection in immunocompromised patients caused by the unusual fungus Pneumocystis jirovecii. Transmission is airborne, with both immunocompromised and immunocompetent individuals acting as a reservoir for ...
Maud Gits-Muselli +12 more
doaj +1 more source
ctDNA Detection of Polyclonal KRAS Resistance in Adagrasib‐Treated NSCLC
Thoracic Cancer, Volume 17, Issue 15, August 2026.Longitudinal ctDNA monitoring by ddPCR and targeted NGS in an adagrasib‐treated KRASG12C mutant NSCLC patient revealed the emergence of three new KRAS mutations (G12D, G13D, Q61H), indicating polyclonal resistance, approximately 10 weeks before any radiologic progression by RECIST 1.1.
Marion Caumeil +5 more
wiley +1 more source
Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance
Emerging Infectious Diseases, 2004 Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sulfa drugs, trimethoprim-sulfamethoxazole (TMP-SMX) and dapsone are mainstays of PCP treatment and prophylaxis.
Laurence Huang +6 more
doaj +1 more source
Evaluation of Global Immune Biomarkers to Predict Infections in Lung Transplant Recipients
Clinical Transplantation, Volume 40, Issue 8, August 2026.ABSTRACT Background Immune biomarkers could assess levels of immunosuppression and predict infections in transplant recipients. We aimed to evaluate the absolute lymphocyte count (ALC), absolute neutrophil count (ANC), Quantiferon‐Monitor and the mitogen component of the Quantiferon‐CMV assay alone and combined to predict serious opportunistic ...
Quoc Nguyen +6 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6584-6594, August 2026.ABSTRACT Introduction Type 1 diabetes (T1D) is a chronic autoimmune disease, characterised by progressive destruction of the insulin‐producing pancreatic β‐cells. Preserving remaining β‐cells at the time of diagnosis may improve long‐term outcomes. Frexalimab is a humanised monoclonal antibody specific for CD40L undergoing evaluation for treatment of ...
Andriy Cherkas +11 more
wiley +1 more source