Results 81 to 90 of about 20,881 (221)

The Efficacy and Safety of Bevacizumab/Irinotecan/Temozolomide (BIT) for Relapsed/Refractory Neuroblastoma: The UK Children's Cancer and Leukaemia Group Experience

Pediatric Blood &Cancer, Volume 73, Issue 5, May 2026.
ABSTRACT Background Patients with high‐risk neuroblastoma who either are refractory to induction chemotherapy or relapse following multi‐modal treatment have a dismal prognosis. Based on data from the BEACON trial, since 2021 the UK national guidelines recommend bevacizumab, irinotecan, and temozolomide (BIT) for patients with relapsed/refractory ...
Thomas J. Jackson, Menna Shamma, Upeka Senanayake, Shaimaa Sahmoud, Kathleen Duffin, Victoria Howard, David King, Ayesha Fathani, Blanche Lumb, Andrei Pobischan, Irum Latif Memon, Monzir Ahmed, Rhian Thomas, Gerard Millen, Yasmeen Alomari, Sucheta Vaidya, Lynley V. Marshall, Sally L. George, Ramya Ramanujachar, Juliet Gray, Paola Angelini   +20 more
wiley   +1 more source

Trichosporon asahii co-infection with Pneumocystis jiroveci in a renal transplant patient

IDCases
Trichosporon asahii is considered an opportunistic pathogen, capable of causing superficial infections in humans and invasive deep-seated infections in immunocompromised hosts.
Tingting Yang, Yajie Fu
doaj   +1 more source

Humans Are Selectively Exposed to Pneumocystis jirovecii

mBio, 2020
Environmental exposure has a significant impact on human health. While some airborne fungi can cause life-threatening infections, the impact of environment on fungal spore dispersal and transmission is poorly understood.
Ousmane H. Cissé, Liang Ma, Chao Jiang, Michael Snyder, Joseph A. Kovacs   +4 more
doaj   +1 more source

Outbreaks of Pneumocystis Pneumonia in 2 Renal Transplant Centers Linked to a Single Strain of Pneumocystis: Implications for Transmission and Virulence [PDF]

, 2017
By restriction fragment length polymorphism analysis, 2 outbreaks of Pneumocystis pneumonia in renal transplant patients in Europe were shown to be caused by the same strain of Pneumocystis; another outbreak in Japan was caused by a different ...
Fehr, Thomas, Gianella, Sara, Gogineni, Emile, Goto, Norihiko, Huber, Charles, Konrad, Regina, Kovacs, Joseph A., Kutty, Geetha, Ma, Liang, Mueller, Nicolas J., Oka, Shinichi, Ripamonti, Chiara, Sassi, Monica, Sing, Andreas, Yazaki, Hirohisa   +14 more
core  

An evaluation of the performance of the Dynamiker® Fungus (1-3)-β-D-Glucan Assay to 2 assist in the diagnosis of Pneumocystis pneumonia [PDF]

, 2017
Invasive fungal disease (IFD) can be caused by a range of pathogens. Conventional diagnosis has the capacity to detect most causes of IFD, but poor performance limits impact. The introduction of non-culture diagnostics, including the detection of (1-3)-β-
Barnes, Rosemary A., Posso, Raquel B., Price, Jessica S., White, P. Lewis   +3 more
core   +3 more sources

Pharmacokinetics of dolutegravir, tenofovir and lamivudine during venous–venous extracorporeal membrane oxygenation (VV‐ECMO): A case report

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1487-1492, May 2026.
While providing potentially life‐saving cardiorespiratory support for critically ill patients, extracorporeal membrane oxygenation (ECMO) may detrimentally affect pharmacokinetic (PK) performance and concurrent drug efficacy and safety. We describe a patient with Pneumocystis jirovecii pneumonia (PJP) in the context of acquired immunodeficiency ...
Tom C. Zwart, Emiel Leegwater, Thomas H. Ottens, Emile F. Schippers, Erik B. Wilms, David M. Burger, Cees van Nieuwkoop, Liesbeth B. E. Bosma   +7 more
wiley   +1 more source

Activated immune cells present a lung interstitial‐to‐airway/alveolar cross‐compartment sharing pattern in severe pneumonia

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
The interstitial‐to‐airway cross‐compartment sharing pattern of activated immune cells provides new insights for severe pneumonia. Macrophages could amplify local immune response by recruiting specific activated immune cells via CXCL10–CXCR3 signalling into airway, while other immune cells reside with limited inflammatory activity.
Yuean Zhao, Linjing Gong, He Yu, Sifan Zhang, Guanglei Yang, Chaoyang Wang, Weiya Wang, Xuyu Cai, Ye Wang   +8 more
wiley   +1 more source

Torque Teno Virus in Bronchoalveolar Lavage Fluid of Hematological Patients and Association With Pathogens

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT Torque teno virus (TTV) replication is tightly modulated by the host immune response. As such, TTV viremia has been investigated as a biomarker of immune competence for monitoring the risks of allograft rejection and opportunistic infections in solid organ transplant recipients.
Mahdi Ouafi, Camille Cordier, David Beauvais, Serge Alfandari, Marie Titécat, Romain Dubois, Frédéric Wallyn, Séverine Loridant, Fanny Vuotto, Micha Srour, Céline Berton, Valérie Coiteux, Ibrahim Yakoub‐Agha, Boualem Sendid, Didier Hober, Enagnon Kazali Alidjinou   +15 more
wiley   +1 more source

Bone Marrow Infection by Pneumocystis jirovecii in a Patient with AIDS: A Case Report and Literature Review

Infectious Disease Reports
Background: Pneumocystis jirovecii primarily causes pneumonia in immunosuppressed individuals, particularly those living with advanced HIV/AIDS. Extrapulmonary dissemination is uncommon, with bone marrow involvement described in only a handful of cases ...
Diego Alejandro Cubides-Diaz, Valentina Negrette-Lazaro, Viviana Poveda-Hurtado, Juan Pablo López-Salazar, Carlos Mauricio Calderón-Vargas, Carlos Arturo Álvarez-Moreno   +5 more
doaj   +1 more source

Efficacy of upadacitinib induction for pediatric inflammatory bowel disease

JPGN Reports, Volume 7, Issue 2, Page 296-300, May 2026.
Abstract Objectives Upadacitinib, a second‐generation Janus kinase (JAK) inhibitor, is approved for moderate to severe Crohn's disease (CD) and ulcerative colitis (UC) in adults. Its efficacy in pediatric patients remains unclear, though early reports suggest benefits in refractory inflammatory bowel disease (IBD).
Evan Greenhall, Nina Gautam, Paula Prieto‐Jimenez, Elizabeth Hilow, Ashish Patel, Brad Pasternak   +5 more
wiley   +1 more source