Results 41 to 50 of about 2,393 (128)

Identification of Orthosteric and Allosteric Pharmacological Chaperones for Mucopolysaccharidosis Type IIIB

ChemBioChem, Volume 25, Issue 15, August 1, 2024.
We modeled substrate interactions in NAGLU′s active site and predicted allosteric sites. Virtual screening against a human‐tested molecule database identified potential pharmacological chaperones (PCs). In vitro evaluations confirmed their binding to NAGLU and ability to restore enzymatic activity in MPS IIIB fibroblasts with mutant enzymes.
Juan Camilo Losada, Heidy Triana, Egdda Vanegas, Angela Caro, Alexander Rodríguez‐López, Angela Johana Espejo‐Mojica, Carlos Javier Alméciga‐Diaz   +6 more
wiley   +1 more source

Molecular Evidence of Interhuman Transmission of Pneumocystis Pneumonia among Renal Transplant Recipients Hospitalized with HIV-Infected Patients

Emerging Infectious Diseases, 2004
Ten Pneumocystis jirovecii pneumonia (PCP) cases were diagnosed in renal transplant recipients (RTRs) during a 3-year period. Nosocomial transmission from HIV-positive patients with PCP was suspected because the these patients shared the same hospital ...
Meja Rabodonirina, Philippe Vanhems, Sandrine Couray-Targe, René-Pierre Gillibert, Christell Ganne, Nathalie Nizard, Cyrille Colin, Jacques Fabry, Jean-Louis Touraine, Guy van Melle, Aimable Nahimana, Patrick Francioli, Philippe M. Hauser   +12 more
doaj   +1 more source

Drug‐induced pneumonitis risk in diffuse large B‐cell/follicular lymphoma patients treated with R‐CHOP‐like regimen is associated with the use of granulocyte colony‐stimulating growth factors

Cancer Medicine, Volume 13, Issue 1, January 2024.
Our findings suggest that the use of granulocyte colony‐stimulating factors increases the incidence of drug‐induced pneumonitis in patients with diffuse large cell lymphoma and follicular lymphoma receiving R‐CHOP‐type treatment. Abstract Background Rituximab‐based combinations are the standard of care in diffuse large B‐cell lymphoma (DLBCL) and ...
Elina Kaprio, Roosa Prusila, Susanna Tokola, Milla E. L. Kuusisto, Esa Jantunen, Hanne Kuitunen, Taina Turpeenniemi‐Hujanen, Outi Kuittinen   +7 more
wiley   +1 more source

FungalRV: adhesin prediction and immunoinformatics portal for human fungal pathogens

BMC Genomics, 2011
Background The availability of sequence data of human pathogenic fungi generates opportunities to develop Bioinformatics tools and resources for vaccine development towards benefitting at-risk patients.
Ramachandran Srinivasan, Raghunandanan Muthukurussi, Ansari Faraz, Chaudhuri Rupanjali   +3 more
doaj   +1 more source

Radiation pneumonitis complicated by Pneumocystis carinii in patients with thoracic neoplasia: a clinical analysis of 7 cases

, 2019
Cancer Communications, Volume 39, Issue 1, Page 1-4, December 2019.
Zhixue Fu, Xu Yang, Nan Bi, Yirui Zhai, Dongfu Chen, Wenqing Wang, Lei Deng, Tao Zhang, Zongmei Zhou, Jun Liang   +9 more
wiley   +1 more source

Evaluating the Efficacy of a Polymerase Chain Reaction Assay for Pneumocystis carinii Detection in Respiratory Samples

Journal of Medical Evidence
Introduction: Accurately identifying patients with pneumocystis pneumonia (PCP) presents considerable challenges, primarily relying on clinical suspicion.
Sonu Kumari Agarwal, Harendra Kumar Thakur, Bansidhar Tarai   +2 more
doaj   +1 more source

Extracellular vesicles from Pneumocystis carinii-infected rats impair fungal viability but are dispensable for macrophage functions

Microbiology Spectrum
Pneumocystis spp. are host obligate fungal pathogens that can cause severe pneumonia in mammals and rely heavily on their host for essential nutrients. The lack of a sustainable in vitro culture system poses challenges in understanding their metabolism ...
Steven G. Sayson, Alan Ashbaugh, Melanie T. Cushion   +2 more
doaj   +1 more source

Frecuencia de la colonización por Pneumocystis jirovecii en pacientes con Enfermedad Pulmonar Obstructiva Crónica en Bogotá, Colombia

Medicina, 2017
Antecedentes: la colonización por Pneumocystis jirovecci (P. jirovecii) se ha postulado como causa de deterioro de la función pulmonar en pacientes con Enfermedad Pulmonar Obstructiva Crónica (EPOC).
Juan Felipe Burbano-Gutiérrez, José Enrique Cita-Pardo, Catalina Hernández-Flórez, Claudia M. Parra-Giraldo, Javier Ricardo Garzón-Herazo, Melva Y. Linares-Linare Linares-Linare, Alejandra Cañas-Arboleda   +6 more
doaj  

Infecciones micóticas oportunistas en pacientes con VIH/SIDA Fungal opportunistic infections in HIV/AIDS patients

Infectio, 2006
Hace 25 años se describieron los primeros casos de la infección por el virus de la inmunodeficiencia humana (VIH) y el desarrollo del síndrome de inmunodeficiencia adquirida (sida).
ÁNGEL GONZÁLEZ, ÁNGELA MARÍA TOBÓN
doaj  

Melanina: implicaciones en la patogénesis de algunas enfermedades y su capacidad de evadir la respuesta inmune del hospedero Melanin: implications in some disease pathogenesis and its capacity to evade the host immune response

Infectio, 2008
La melanina es uno de los pigmentos más comunes y de mayor distribución en la naturaleza. Es responsable de la coloración de plantas y animales; se encuentra en los ojos, el cabello, la piel, el plumaje, la cáscara de los huevos, la cutícula de los ...
Martha Eugenia Urán, Luz Elena Cano
doaj