ChemBioChem, Volume 25, Issue 15, August 1, 2024.We modeled substrate interactions in NAGLU′s active site and predicted allosteric sites. Virtual screening against a human‐tested molecule database identified potential pharmacological chaperones (PCs). In vitro evaluations confirmed their binding to NAGLU and ability to restore enzymatic activity in MPS IIIB fibroblasts with mutant enzymes.
Juan Camilo Losada +6 more
wiley +1 more source
Emerging Infectious Diseases, 2004 Ten Pneumocystis jirovecii pneumonia (PCP) cases were diagnosed in renal transplant recipients (RTRs) during a 3-year period. Nosocomial transmission from HIV-positive patients with PCP was suspected because the these patients shared the same hospital ...
Meja Rabodonirina +12 more
doaj +1 more source
High prevalence of Pneumocystis jirovecii pneumonia among Mozambican children < 5 years of age admitted to hospital with clinical severe pneumonia [PDF]
, 2016 We aimed to describe Pneumocystis jirovecii pneumonia (PCP) prevalence and features in children from sub-Saharan Africa, and to investigate PCP-associated risk factors.
Acácio, Sozinho +12 more
core +1 more source
Cancer Medicine, Volume 13, Issue 1, January 2024.Our findings suggest that the use of granulocyte colony‐stimulating factors increases the incidence of drug‐induced pneumonitis in patients with diffuse large cell lymphoma and follicular lymphoma receiving R‐CHOP‐type treatment. Abstract Background Rituximab‐based combinations are the standard of care in diffuse large B‐cell lymphoma (DLBCL) and ...
Elina Kaprio +7 more
wiley +1 more source
PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity [PDF]
, 2010 Primacenes, novel ferrocene-primaquine conjugates, were synthesized and screened for their antimalarial and anti-pneumocystis activity. Primacenes obtained by coupling primaquine amino acid derivatives to ferrocenoic acid were significantly active ...
Jiri Gut +7 more
core +1 more source
FungalRV: adhesin prediction and immunoinformatics portal for human fungal pathogens
BMC Genomics, 2011 Background The availability of sequence data of human pathogenic fungi generates opportunities to develop Bioinformatics tools and resources for vaccine development towards benefitting at-risk patients.
Ramachandran Srinivasan +3 more
doaj +1 more source
Isolation of the Pneumocystis carinii dihydrofolate synthase gene and functional complementation in Saccharomyces cerevisiae [PDF]
, 2017 The Pneumocystis carinii gene encoding the enzyme dihydrofolate synthase (DHFS), which is involved in the essential biosynthesis of folates, was isolated from clones of the Pneumocystis genome project, and sequenced. The deduced P.
Hauser, Philippe M., Macreadie, Ian G.
core
Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus [PDF]
, 2016 Although there are high survival rates for children with acute lymphoblastic leukaemia, their outcome is often counterbalanced by the burden of toxic effects.
Attarbaschi, Andishe +20 more
core +2 more sources
Detection of Pneumocystis jirovecii by Two Staining Methods and Two Quantitative PCR Assays [PDF]
, 2018 : Background: : Pneumocystis jirovecii is an opportunistic pathogen that causes pneumonia, particularly in immunodeficient hosts. Materials and Methods: : We retrospectively compared the results obtained by two staining methods (toluidine blue and ...
Graf, J.-D +4 more
core
Rising Prevalence of Pneumocystis jirovecii Pneumonia Amongst the Non-HIV Immunosuppressed [PDF]
, 2015 INTRODUCTION Fungal Pneumonia caused by Pnemocystis Jirovecci (PCP) has long been associated with morbidity and mortality in HIV-positive patients.
Ganesh, MD, Anusha, Jones, MD, Zachary
core +2 more sources