Results 111 to 120 of about 5,963 (243)

Crystal structure and biophysical characterisation of the enterococcal foldase PpiC, a cross‐opsonic antigen against gram‐positive nosocomial pathogens

The FEBS Journal, Volume 292, Issue 20, Page 5475-5490, October 2025.
PpiC is an enterococcal lipoprotein endowed with both Peptidyl‐prolyl cis‐trans isomerase (PPIase) and foldase activities. It is a potential target for novel antimicrobials and a promising vaccine antigen. We determined the crystal structure of the enzyme, showing that PpiC adopts a dimeric organisation embedding two catalytic parvulin‐type PPIase ...
Valeria Napolitano, Eliza Kramarska, Ornella Ghilardi, Felipe Romero‐Saavedra, Pompea Del Vecchio, Flavia Squeglia, Johannes Huebner, Rita Berisio   +7 more
wiley   +1 more source

Magnesium therapy improves outcome in Streptococcus pneumoniae meningitis by altering pneumolysin pore formation [PDF]

, 2017
Background and purposeStreptococcus pneumoniae is the most common cause of bacterial meningitis in adults and is characterised by high lethality and substantial cognitive disabilities in survivors.
Ribes, Sandra, Elke Maier, Benz, Roland, Christina Förtsch, Seele, Jana, Iliev, Asparouh Iliev, Sabrina Hupp, Bischoff, Carolin, Timothy J Mitchell, Sandra Ribes, Maier, Elke, Förtsch, Christina, Jana Seele, Carolin Bischoff, Hupp, Sabrina, Mitchell, Timothy J, Roland Benz, Roland Nau, Asparouh I Iliev, Iliev, Asparouh I, Nau, Roland   +20 more
core   +1 more source

Systematic Review on the Role of Microfluidic Platforms in Advancing Scalable and Precise Microbial Bioprocessing

Engineering in Life Sciences, Volume 25, Issue 9, September 2025.
ABSTRACT Microbial bioprocessing is a key technology for the production of a wide range of biomolecules, including proteins, enzymes, antibiotics, and other bioactive compounds. In recent years, there has been an increasing interest in using microfluidic platforms for bioprocessing, due to the ability to precisely control and manipulate fluids at the ...
Alperen Alpural, Ilgin Kimiz‐Gebologlu, Mayur Parekh, Esra Imamoglu, Zulfiqur Ali, Ozlem Yesil‐Celiktas   +5 more
wiley   +1 more source

Pneumolysin causes neuronal cell death through mitochondrial damage

, 2007
Bacterial toxins such as pneumolysin are key mediators of cytotoxicity in infections. Pneumolysin is a pore-forming toxin released by Streptococcus pneumoniae, the major cause of bacterial meningitis.
Mitchell, Tim J, Bermpohl, Daniela, Weber, Joerg R., Bechmann, Ingo, Braun, Johann S, Hoffmann, Olaf, Schickhaus, Miriam, Weber, Joerg R, Braun, Johann S., Freyer, Dorette, Dagand, Emilie, Mitchell, Tim J.   +11 more
core   +1 more source

Toxicity of pneumolysin to pulmonary alveolar epithelial cells [PDF]

Infection and Immunity, 1993
Mortality during the first several days of pneumococcal pneumonia has not decreased appreciably over the past 30 years, despite the widespread use of antibiotics. Disruption of the alveolar epithelial barrier is likely an initial step in the pathogenesis of pneumococcal pneumonia.
J B, Rubins, P G, Duane, D, Clawson, D, Charboneau, J, Young, D E, Niewoehner   +5 more
openaire   +2 more sources

Detection of pbp2b and ermB genes in clinical isolates of Streptococcus pneumoniae

Journal of Infection in Developing Countries, 2008
Background: Streptococcus pneumoniae is a major human pathogen. The emergence of penicillin resistant strains since the 1970s has been life threatening and the evolution of the bacteria have enabled itself to develop resistance to many other antibiotics ...
Navindra Kumari, Parasakthi Navaratnam, Shamala Devi Sekaran   +2 more
doaj   +1 more source

Citrus Flavonoids as Antimicrobials

Chemistry &Biodiversity, Volume 22, Issue 6, June 2025.
Citrus flavonoids are powerful and versatile antimicrobials whose mechanism of action often involves disruption of the bacterial membrane, thereby minimizing antimicrobial resistance. This study provides a unified perspective. ABSTRACT Citrus flavonoids are highly bioactive compounds exerting numerous health benefits including anticancer, antioxidant ...
Rosaria Ciriminna, Giovanna Li Petri, Giuseppe Angellotti, Rafael Luque, Anne‐Sylvie Fabiano Tixier, Francesco Meneguzzo, Mario Pagliaro   +6 more
wiley   +1 more source

Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest

, 2015
Streptococcus pneumoniae produces pneumolysin toxin as a key virulence factor against host cells. Pneumolysin is a cholesterol-dependent cytolysin (CDC) toxin that forms lytic pores in host membranes and mediates pneumococcal disease pathogenesis by ...
Chow, Vincent H., Rai, Prashant, He, Fang, 1956-, Kwang, Jimmy, Engelward, Bevin P   +4 more
core   +1 more source

Platelets and Their Role in the Pathogenesis of Cardiovascular Events in Patients With Community-Acquired Pneumonia

Frontiers in Immunology, 2020
Community-acquired pneumonia (CAP) remains an important cause of morbidity and mortality throughout the world with much recent and ongoing research focused on the occurrence of cardiovascular events (CVEs) during the infection, which are associated with ...
Charles Feldman, Ronald Anderson
doaj   +1 more source

Neuroimmune interactions: The bridge between inflammatory bowel disease and the gut microbiota

Clinical and Translational Medicine, Volume 15, Issue 5, May 2025.
The gut microbiota regulates the gut–brain–immune axis, modulating neuroimmune interactions in inflammatory bowel disease (IBD). Microbiota‐derived metabolites influence immune cells, driving cytokine release that activates dorsal root ganglion (DRG) neurons.
Jinxia Zhai, Yingjie Li, Jiameng Liu, Cong Dai   +3 more
wiley   +1 more source