Results 101 to 110 of about 5,963 (243)

Influence of the mRNA initial region on protein production: a case study using recombinant detoxified pneumolysin as a model

Frontiers in Bioengineering and Biotechnology
Recombinant proteins are of great importance in modern society, mostly as biopharmaceutical products. However, challenging and complex processes with low production yield are major drawbacks.
F. Fusco, M. C. Pires, A. P. Y. Lopes, Vítor S. Alves, V. M. Gonçalves   +4 more
semanticscholar   +1 more source

Immunodominance in T cell responses elicited against different domains of detoxified pneumolysin PlyD1. [PDF]

PLoS ONE, 2018
Detoxified pneumolysin, PlyD1, is a protein vaccine candidate that induces protection against infections with Streptococcus pneumoniae in mouse models.
Els van Westen, Martien C M Poelen, Germie P J M van den Dobbelsteen, Eliud O Oloo, Martina M Ochs, Nynke Y Rots, Cecile A C M van Els   +6 more
doaj   +1 more source

Recent progress in pneumococcal protein vaccines

Frontiers in Immunology, 2023
Pneumococcal infections continue to pose a significant global health concern, necessitating the development of effective vaccines. Despite the progress shown by pneumococcal polysaccharide and conjugate vaccines, their limited coverage and the emergence ...
Sha Li, Hangeri Liang, Shui-Hao Zhao, Xiao-Yan Yang, Zhong Guo   +4 more
doaj   +1 more source

Mechanistic Landscape and Farm to Fork Control Strategies for Streptococcus suis: An Emerging Foodborne Threat

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Streptococcus suis (S. suis) is an emerging zoonotic agent that now rivals classical food‐borne pathogens in its global clinical burden of meningitis and septic shock. Recent epidemiological syntheses covering more than 30 countries now list over 1600 laboratory‐confirmed human cases with a pooled case‐fatality of about 12%, climbing beyond 18% in East
Wangyuan Yao, Meili Chen, Hongkai Ren, Qingqing Luo, Xuyuan Wang, Md. Akhtar, Zeeshan Ahmad Bhutta, Lianci Peng, Muhammad Yasir Nawaz, Mohammad Mehedi Hasan, Md. F. Kulyar, Rendong Fang, Zhong Peng   +12 more
wiley   +1 more source

Membrane Cholesterol Content and Lipid Organization Influence Melittin and Pneumolysin Pore-Forming Activity

Toxins, 2022
Melittin, the main toxic component in the venom of the European honeybee, interacts with natural and artificial membranes due to its amphiphilic properties.
Shamish Ganpule, Akshay Kumar Vijaya, Aleksandra Sukova, G. Preta   +3 more
semanticscholar   +1 more source

Neutrophil-Derived Extracellular Vesicles Activate Platelets after Pneumolysin Exposure

Cells, 2021
Pneumolysin (PLY) is a pore-forming toxin of Streptococcus pneumoniae that contributes substantially to the inflammatory processes underlying pneumococcal pneumonia and lung injury. Host responses against S.
E. Letsiou, L. T. Teixeira Alves, M. Felten, T. Mitchell, H. Müller-Redetzky, S. Dudek, M. Witzenrath   +6 more
semanticscholar   +1 more source

Matcha Green Tea Exhibits Bactericidal Activity against Streptococcus pneumoniae and Inhibits Functional Pneumolysin

Antibiotics, 2021
Streptococcus pneumoniae is a causative pathogen of several human infectious diseases including community-acquired pneumonia. Pneumolysin (PLY), a pore-forming toxin, plays an important role in the pathogenesis of pneumococcal pneumonia. In recent years,
Karin Sasagawa, Hisanori Domon, Rina Sakagami, Satoru Hirayama, Tomoki Maekawa, Toshihito Isono, Takumi Hiyoshi, Hikaru Tamura, Fumio Takizawa, Yoichi Fukushima, Koichi Tabeta, Yutaka Terao   +11 more
doaj   +1 more source

Infectious Triggers and Immune Dynamics in Guillain–Barré Syndrome: Revisiting Campylobacter jejuni and the Silent Role of Haemophilus influenzae

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Schematic representation of the gut‐brain axis and microbial triggers in Guillain–Barré Syndrome. Post‐infectious immune responses, particularly through molecular mimicry by pathogens, such as Campylobacter jejuni and Haemophilus influenzae, lead to demyelination and subsequent neuromuscular paralysis.
Aswathi Ramesh, Rajasekaran Subbarayan, Dhasarathdev Srinivasan, Ranjith Balakrishnan, Rupendra Shrestha, Ankush Chauhan   +5 more
wiley   +1 more source

Activation of human complement by the pneumococcal toxin pneumolysin [PDF]

Infection and Immunity, 1984
Highly purified pneumolysin (at a concentration of 10 micrograms/ml) caused significant activation of human complement, as measured by conversion of C3. Complement activation in the presence of pneumolysin was not observed in sera chelated with a combination of Mg2+ and ethylene glycol-bis(beta-aminoethyl ether)-N,N-tetraacetic acid, and activation was
J C, Paton, B, Rowan-Kelly, A, Ferrante
openaire   +2 more sources

Two Sides of the Same Coin—Mechanistic Insight, Diagnostic Application and Therapeutic Translation of Bacterial and Host‐Derived Extracellular Vesicles

Journal of Extracellular Biology, Volume 4, Issue 11, November 2025.
ABSTRACT Extracellular vesicles (EVs) have gained increasing attention in recent years due to their pivotal role in both health and disease. Emerging from both eukaryotic and prokaryotic cells, EVs serve as essential mediators of intercellular communication, exceeding the simplistic interactions observed with individual molecules. In this comprehensive
Philipp Arnold, Fanni Annamária Boros, Jochen Mattner, Gerald Seidel, Chaofan Liu, Inga Viktoria Hensel, Jan Van Deun, Raphael Schwendner, Janina Müller‐Deile, Nina Sopel, Andreas Ramming, Mario R. Angeli, Simon Rauber, Cláudia Vilhena, Andreas Baur, Stefan Wirtz, Klaus Überla, Heiko Reutter, Linda‐Marie Mulzer, Alina C. Hilger, Friederike Zunke, Wei Xiang, Gregor Fuhrmann, Claudia Günther   +23 more
wiley   +1 more source