Results 81 to 90 of about 5,963 (243)

Toxicity of pneumolysin to pulmonary endothelial cells in vitro [PDF]

Infection and Immunity, 1992
Pneumococcal pneumonia and bacteremia are associated with appreciable mortality, most of which occurs very early in the course of infection. An initial step in the pathogenesis of pneumococcal pneumonia may include disruption of the pulmonary endothelial barrier with subsequent alveolar hemorrhage.
J B, Rubins, P G, Duane, D, Charboneau, E N, Janoff   +3 more
openaire   +2 more sources

Pneumococcal sialidase promotes bacterial survival by fine-tuning of pneumolysin-mediated membrane disruption.

Cell Reports
Pneumolysin (Ply) is an indispensable cholesterol-dependent cytolysin for pneumococcal infection. Although Ply-induced disruption of pneumococci-containing endosomal vesicles is a prerequisite for the evasion of endolysosomal bacterial clearance, its ...
Sayaka Shizukuishi, Michinaga Ogawa, Eisuke Kuroda, Shigeto Hamaguchi, Chisato Sakuma, S. Kakuta, I. Tanida, Yasuo Uchiyama, Y. Akeda, Akihide Ryo, Makoto Ohnishi   +10 more
semanticscholar   +1 more source

Pneumolysin suppresses the initial macrophage pro‐inflammatory response to Streptococcus pneumoniae

Immunology, 2022
Published data for the Streptococcus pneumoniae virulence factor Pneumolysin (Ply) show contradictory effects on the host inflammatory response to infection.
J. Periselneris, Carolin T. Turner, G. Ercoli, G. Szylar, C. Weight, Teresa L. M. Thurston, M. Whelan, G. Tomlinson, M. Noursadeghi, Jeremy S. Brown   +9 more
semanticscholar   +1 more source

Macrocyclic Peptide Probes for Immunomodulatory Protein CD59: Potent Modulators of Bacterial Toxin Activity and Antibody‐Dependent Cytotoxicity

Angewandte Chemie, Volume 137, Issue 27, July 1, 2025.
This study presents novel macrocyclic peptides with low nanomolar affinity for CD59, an immunomodulatory cell surface receptor associated with human disease. Crystallographic and structure‐activity relationship (SAR) studies reveal peptide CP‐06 mimics the binding of biologically relevant CD59 interaction partners. Dimeric and lipidated CP‐06 analogues
Jasmine K. Bickel, Ammar. I. S. Ahmed, Aidan B. Pidd, Rhodri M. Morgan, Tom E. McAllister, Sam Horrell, Emma C. Couves, Hemavathi Nagaraj, Edward J. Bartlett, Kamel El Omari, Akane Kawamura, Doryen Bubeck, Edward W. Tate   +12 more
wiley   +2 more sources

Truncated Pneumolysin from Streptococcus pneumoniae as a TLR4-Antagonizing New Drug for Chronic Inflammatory Conditions

Cells, 2020
Microbial proteins have recently been found to have more benefits in clinical disease treatment because of their better-developed strategy and properties than traditional medicine.
Shun-Fu Chang, Cheng-Nan Chen, Jung-Chung Lin, Hsin-Ell Wang, Shigetarou Mori, Jia-Je Li, Chia-Kuang Yen, Ching-Yun Hsu, Chang-Phone Fung, Pele Choi-Sing Chong, Chih-Hsiang Leng, Yi-Jun Ding, Feng-Yee Chang, L. Kristopher Siu   +13 more
doaj   +1 more source

Mucins protect against Streptococcus pneumoniae virulence by suppressing pneumolysin expression. [PDF]

J Clin Invest
To the Editor:Streptococcus pneumoniae (Spn) is a common member of the human nasopharyngeal microflora; yet, this same bacterium inflicts tissue damage and considerable mortality worldwide (1).
Bath J, Bjånes E, Goekeri C, Hsiao J, Uzun D, Nouailles G, Nizet V, Ribbeck K.   +7 more
europepmc   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, Volume 600, Issue 6, Page 864-893, March 2026.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The role of pneumolysin in pneumococcal pneumonia and meningitis

Clinical and Experimental Immunology, 2004
SUMMARYDiseases caused by Streptococcus pneumoniae include pneumonia, septicaemia and meningitis. All these are associated with high morbidity and mortality. The pneumococcus can colonize the nasopharynx, and this can be a prelude to bronchopneumonia and invasion of the vasculature space.
Hirst, RA, Kadioglu, A, O'callaghan, C, Andrew, PW   +3 more
openaire   +4 more sources

Corilagin: A Novel Antivirulence Strategy to Alleviate Streptococcus pneumoniae Infection by Diminishing Pneumolysin Oligomers

Molecules, 2022
Pneumolysin (PLY) is a significant virulence factor of Streptococcus pneumoniae (S. pneumoniae), able to break through the defense system of a host and mediate the occurrence of a series of infections. Therefore, PLY as the most ideal target to prevent S.
Qiushuang Sheng, Xiaoning Hou, Nan Wang, Minda Liu, Haoyu Zhu, Xuming Deng, Xiaoying Liang, Gefu Chi   +7 more
semanticscholar   +1 more source

Pneumolysin-damaged cells benefit from non-homogeneous toxin binding to cholesterol-rich membrane domains.

, 2018
Nucleated cells eliminate lesions induced by bacterial pore-forming toxins, such as pneumolysin via shedding patches of damaged plasmalemma into the extracellular milieu.
Roman Schoenauer, Patrick Drücker, Draeger, Annette, Viktoria S. Babiychuk, Eduard B. Babiychuk, Schönauer, Roman, Simon Bachler, Heidi Wolfmeier, Annette Draeger, Dittrich, Petra S, Bachler, Simon, Wolfmeier, Heidi Annemarie, Petra S. Dittrich, Drücker, Patrick, Babiychuk, Eduard, René Köffel, Köffel, René, Babiychuk, Viktoria S   +17 more
core   +1 more source