Results 71 to 80 of about 5,963 (243)

The detection of altered penicillin-binding protein 2b, autolysin, and pneumolysin genes in Streptococcus pneumoniae colonizing the upper respiratory tract of healthy schoolchildren in Puducherry

Journal of Current Research in Scientific Medicine, 2019
Background: Infections due to Streptococcus pneumoniae are responsible for morbidity and mortality in a large proportion of children in developing countries where childhood vaccination has not been widely implemented. S.
Divya Suguna Jayakar, Noyal Mariya Joseph, Patricia Anitha, Reba Kanungo   +3 more
doaj   +1 more source

Peptide linker increased the stability of pneumococcal fusion protein vaccine candidate

Frontiers in Bioengineering and Biotechnology, 2023
Streptococcus pneumoniae is a bacterial pathogen exclusive to humans, responsible for respiratory and systemic diseases. Pneumococcal protein vaccines have been proposed as serotype-independent alternatives to currently used conjugated polysaccharide ...
Luciano Zane, Luciano Zane, Stefanie Kraschowetz, Stefanie Kraschowetz, Monalisa Martins Trentini, Vitor dos Santos Alves, Vitor dos Santos Alves, Sergio Carneiro Araujo, Sergio Carneiro Araujo, Cibelly Goulart, Cibelly Goulart, Luciana Cezar de Cerqueira Leite, Viviane Maimoni Gonçalves   +12 more
doaj   +1 more source

Effects of pneumolysin on human polymorphonuclear leukocytes and platelets [PDF]

Infection and Immunity, 1981
Pneumolysin was bound by human polymorphonuclear leukocytes in a reaction which occurred very rapidly at 0 degrees C. Low concentrations of pneumolysin were found to stimulate leukocyte migration and lysosomal enzyme secretion. At increasing lysin levels, inhibition of spontaneous migration and chemotaxis, cell death, and lysis were observed ...
M K, Johnson, D, Boese-Marrazzo, W A, Pierce   +2 more
openaire   +2 more sources

Interaction of pneumolysin with human platelets [PDF]

, 2022
Earlier studies regarded mainly membrane cholesterol as the cellular receptor for cholesterol dependent cytolysins (CDCs) like pneumolysin but growing evidence suggests a crucial role for glycans as possible receptors or mediators. However, their precise
Fritsch, Kristin Juliet
core  

Novel Role for the Streptococcus pneumoniae Toxin Pneumolysin in the Assembly of Biofilms

mBio, 2013
Streptococcus pneumoniae is an important commensal and pathogen responsible for almost a million deaths annually in children under five. The formation of biofilms by S.
Joshua R. Shak, Herbert P. Ludewick, Kristen E. Howery, Fuminori Sakai, Hong Yi, Richard M. Harvey, James C. Paton, Keith P. Klugman, Jorge E. Vidal   +8 more
doaj   +1 more source

Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation

mBio, 2014
Intracellular killing of Streptococcus pneumoniae is complemented by induction of macrophage apoptosis. Here, we show that the toxin pneumolysin (PLY) contributes both to lysosomal/phagolysosomal membrane permeabilization (LMP), an upstream event ...
Martin A. Bewley, Michael Naughton, Julie Preston, Andrea Mitchell, Ashleigh Holmes, Helen M. Marriott, Robert C. Read, Timothy J. Mitchell, Moira K. B. Whyte, David H. Dockrell   +9 more
doaj   +1 more source

Lung Microbiome Diversity, Infection Dynamics, and Microbe‐Mediated Cross‐Protection

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The protective role of the lung microbiome in maintaining respiratory health by promoting immune homeostasis, pathogen exclusion, and barrier integrity. Diverse microbial communities regulate immune maturation, enhance epithelial defenses, and contribute to antiviral responses, collectively preventing pathogen colonization and sustaining a balanced ...
Sana Arooj, Akmal Zubair, Syeda Zaira Batool, Granaz Niaz, Muhammad Ali, Yasir Waheed, Eman Ramadan Elsharkawy, Naila Afghan   +7 more
wiley   +1 more source

Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxins

Nature Communications
Pneumolysin (PLY) is a cholesterol-dependent cytolysin (CDC) from Streptococcus pneumoniae, the main cause for bacterial pneumonia. Liberation of PLY during infection leads to compromised immune system and cytolytic cell death. Here, we report discovery,
Umer Aziz, A. Saoud, M. Bermudez, Maren Mieth, Amira Atef, Thomas Rudolf, Christoph Arkona, Timo Trenkner, Christoph Böttcher, Kai Ludwig, Angelique Hoelzemer, A. Hocke, Gerhard Wolber, Jörg Rademann   +13 more
semanticscholar   +1 more source

Active release of pneumolysin prepores and pores by mammalian cells undergoing a Streptococcus pneumoniae attack. [PDF]

, 2016
BACKGROUND Streptococcus pneumoniae is a potent human pathogen. Its pore-forming exotoxin pneumolysin is instrumental for breaching the host's epithelial barrier and for the incapacitation of the immune system.
Wolfmeier, Heidi, Radecke, Julika, Babiychuk, Eduard B., Draeger, Annette, Babiychuk, Viktoria S., Hathaway, Lucy Jane, Schönauer, Roman, Koeffel, René, Hathaway, Lucy J., Zuber, Benoît, Wolfmeier, Heidi Annemarie, Drücker, Patrick, Babiychuk, Victoria, Babiychuk, Eduard, Mitchell, Timothy J., Mitchell, Timothy J, Köffel, René, Schoenauer, Roman   +17 more
core   +1 more source

Several plant self‐incompatibility systems may be controlled by atypical receptor–ligand interactions

The Plant Journal, Volume 126, Issue 1, April 2026.
SUMMARY Self‐incompatibility (SI) is the single most important mechanism utilized by flowering plants to avoid self‐fertilization, thus preventing inbreeding and promoting outcrossing. Many plant SI systems are genetically controlled by a multi‐allelic S‐locus, containing two tightly linked genes that encode the female and male S‐determinants.
Zongcheng Lin, Maurice Bosch, Vernonica E. Franklin‐Tong   +2 more
wiley   +1 more source