Results 51 to 60 of about 5,963 (243)

The pneumococcal polysaccharide capsule and pneumolysin differentially affect CXCL8 and IL-6 release from cells of the upper and lower respiratory tract. [PDF]

PLoS ONE, 2014
The polysaccharide capsule and pneumolysin toxin are major virulence factors of the human bacterial pathogen Streptococcus pneumoniae. Colonization of the nasopharynx is asymptomatic but invasion of the lungs can result in invasive pneumonia.
Eliane Küng, William R Coward, Daniel R Neill, Hesham A Malak, Kathrin Mühlemann, Aras Kadioglu, Markus Hilty, Lucy J Hathaway   +7 more
doaj   +1 more source

Streptococcus pneumoniae potently induces cell death in mesothelial cells. [PDF]

PLoS ONE, 2018
Pleural infection/empyema is common and its incidence continues to rise. Streptococcus pneumoniae is the commonest bacterial cause of empyema in children and among the commonest in adults.
Rabab Rashwan, Julius F Varano Della Vergiliana, Sally M Lansley, Hui Min Cheah, Natalia Popowicz, James C Paton, Grant W Waterer, Tiffany Townsend, Ian Kay, Jeremy S Brown, Y C Gary Lee   +10 more
doaj   +1 more source

Cirrhosis-induced defects in innate pulmonary defenses against Streptococcus pneumoniae

BMC Microbiology, 2007
Background The risk of mortality from pneumonia caused by Streptococcus pneumoniae is increased in patients with cirrhosis. However, the specific pneumococcal virulence factors and host immune defects responsible for this finding have not been clearly ...
Vander Top Elizabeth A, Preheim Laurel C, Propst-Graham Katie L, Snitily Mary U, Gentry-Nielsen Martha J   +4 more
doaj   +1 more source

Anticytotoxin Effects of Amentoflavone to Pneumolysin

Biological & Pharmaceutical Bulletin, 2017
Pneumolysin (PLY) is a devastating bacterial protein toxin of Streptococcus pneumoniae that punctures the cytomembrane, leading to pathological reactions, such as cell disruption and inflammation. Drugs capable of closely impacting the toxin are considered advantageous in the treatment of bacterial infections.
Zhao, Xiaoran, Liu, Bowen, Liu, Shui, Wang, Lin, Wang, Jianfeng   +4 more
openaire   +3 more sources

Streptococcus pneumoniae Affects Endothelial Cell Migration in Microfluidic Circulation

Frontiers in Microbiology, 2022
Bloodstream infections caused by Streptococcus pneumoniae induce strong inflammatory and procoagulant cellular responses and affect the endothelial barrier of the vascular system.
Anna Kopenhagen, Isabell Ramming, Isabell Ramming, Belinda Camp, Belinda Camp, Sven Hammerschmidt, Marcus Fulde, Mathias Müsken, Michael Steinert, Michael Steinert, Simone Bergmann   +10 more
doaj   +1 more source

Serum antibodies to pneumolysin in patients with pneumonia [PDF]

Journal of Clinical Microbiology, 1988
Serum antibodies to purified pneumolysin were determined by enzyme-linked immunosorbent assay (ELISA) in paired samples from 406 adult patients with community-acquired pneumonia and in samples from 184 healthy controls. A high sensitivity (83%) was obtained in patients with blood culture-confirmed pneumococcal pneumonia.
K, Kanclerski, S, Blomquist, M, Granström, R, Möllby   +3 more
openaire   +2 more sources

The unremarkable alveolar epithelial glycocalyx: a thorium dioxide-based electron microscopic comparison after heparinase or pneumolysin treatment

Histochemistry and Cell Biology, 2023
Recent investigations analyzed in depth the biochemical and biophysical properties of the endothelial glycocalyx. In comparison, this complex cell-covering structure is largely understudied in alveolar epithelial cells.
S. Timm, M. Lettau, J. Hegermann, M. L. Rocha, S. Weidenfeld, D. Fatykhova, B. Gutbier, G. Nouailles, E. Lopez-Rodriguez, A. Hocke, S. Hippenstiel, M. Witzenrath, W. Kuebler, M. Ochs   +13 more
semanticscholar   +1 more source

Viability and Virulence of Pneumolysin, Pneumococcal Surface Protein A, and Pneumolysin/Pneumococcal Surface Protein A Mutants in the Ear [PDF]

JAMA Otolaryngology–Head & Neck Surgery, 2013
Understanding how pneumococcal proteins affect the pathology of the middle ear and inner ear is important for the development of new approaches to prevent otitis media and its complications.To determine the viability and virulence of Streptococcus pneumoniae mutants deficient in pneumolysin (Ply-) and pneumococcal surface protein A (PspA-) in the ...
Patricia A, Schachern, Vladimir, Tsuprun, Sarah, Goetz, Sebahattin, Cureoglu, Steven K, Juhn, David E, Briles, Michael M, Paparella, Patricia, Ferrieri   +7 more
openaire   +2 more sources

Naturally-occurring serotype 3 Streptococcus pneumoniae strains that lack functional pneumolysin and autolysin have attenuated virulence but induce localized protective immune responses

PLoS ONE, 2023
Streptococcus pneumoniae is an important cause of fatal pneumonia in humans. These bacteria express virulence factors, such as the toxins pneumolysin and autolysin, that drive host inflammatory responses.
Ηαnnah E Wong, Panagiotis Tourlomousis, G. K. Paterson, S. Webster, C. Bryant   +4 more
semanticscholar   +1 more source

Bacterial pore-forming toxin pneumolysin: Cell membrane structure and microvesicle shedding capacity determines differential survival of immune cell types

, 2020
Bacterial infectious diseases can lead to death or to serious illnesses. These outcomes are partly the consequence of pore‐forming toxins, which are secreted by the pathogenic bacteria (eg, pneumolysin of Streptococcus pneumoniae).
Babiychuk, Eduard B., Iacovache, Mircea Ioan, Larpin, Yu, Besançon, Hervé, Draeger, Annette, Babiychuk, Victoriia S., Köffel, René, Zuber, Benoît   +7 more
core   +1 more source