Results 31 to 40 of about 5,963 (243)

Pneumolysin Is Responsible for Differential Gene Expression and Modifications in the Epigenetic Landscape of Primary Monocyte Derived Macrophages

Frontiers in Immunology, 2021
Epigenetic modifications regulate gene expression in the host response to a diverse range of pathogens. The extent and consequences of epigenetic modification during macrophage responses to Streptococcus pneumoniae, and the role of pneumolysin, a key ...
Joby Cole, Joby Cole, Joby Cole, Joby Cole, Adrienn Angyal, Richard D. Emes, Richard D. Emes, Tim John Mitchell, Mark J. Dickman, David H. Dockrell   +9 more
doaj   +1 more source

Purification of Pneumolysin [PDF]

Infection and Immunity, 1971
A procedure for the purification of pneumolysin has been developed. Its use results in a 96-fold increase in specific activity from the original crude pneumococcal extract to the final purified product. The purified material is heat-labile and is inactivated by trypsin and cholesterol; inactivation by p ...
C N, Shumway, S J, Klebanoff
openaire   +2 more sources

Inhibition of Pneumolysin Cytotoxicity by Hydrolyzable Tannins [PDF]

Antibiotics, 2020
Streptococcus pneumoniae causes invasive infections such as otitis media, pneumonia and meningitis. It produces pneumolysin (Ply) toxin, which forms a pore to host cell membrane and has multiple functions in S. pneumoniae pathogenesis. The Ply C-terminal domain 4 mediates binding to membrane cholesterol and induces the formation of pores composed of up
Santeri Maatsola, Sami Kurkinen, Marica T. Engström, Thomas K. M. Nyholm, Olli Pentikäinen, Juha-Pekka Salminen, Sauli Haataja   +6 more
openaire   +4 more sources

Physical Behavior of Pneumolysin [PDF]

Journal of Bacteriology, 1969
Pneumolysin behaved as an acidic protein having an isoelectricpH of 4.9, a molecular weight of approximately 63,000, and a sedimentation coefficient of approximately 4.3.
A S, Kreger, A W, Bernheimer
openaire   +2 more sources

The Role of Neutrophils and Neutrophil Elastase in Pneumococcal Pneumonia

Frontiers in Cellular and Infection Microbiology, 2021
Streptococcus pneumoniae, also known as pneumococcus, is a Gram-positive diplococcus and a major human pathogen. This bacterium is a leading cause of bacterial pneumonia, otitis media, meningitis, and septicemia, and is a major cause of morbidity and ...
Hisanori Domon, Hisanori Domon, Yutaka Terao, Yutaka Terao   +3 more
doaj   +1 more source

Pneumolysin as a target for new therapies against pneumococcal infections: A systematic review

PLoS ONE, 2023
Background This systematic review evaluates pneumolysin (PLY) as a target for new treatments against pneumococcal infections. Pneumolysin is one of the main virulence factors produced by all types of pneumococci. This toxin (53 kDa) is a highly conserved
María Dolores Cima Cabal, F. Molina, J. López-Sánchez, E. Pérez-Santín, María Del Mar García-Suárez   +4 more
semanticscholar   +1 more source

Wogonin attenuates the pathogenicity of Streptococcus pneumoniae by double‐target inhibition of Pneumolysin and Sortase A

Journal of Cellular and Molecular Medicine, 2023
Streptococcus pneumoniae (S. pneumoniae) is a major causative agent of respiratory disease in patients and can cause respiratory distress and other symptoms in severe cases.
Kuan Gu, Lizhong Ding, Zhongtian Wang, Yingying Sun, Xiaozhou Sun, Wenbo Yang, Haihang Sun, Ye Tian, Zeyu Wang, Liping Sun   +9 more
semanticscholar   +1 more source

Extracellular calcium reduction strongly increases the lytic capacity of pneumolysin from streptococcus pneumoniae in brain tissue [PDF]

, 2011
Background. Streptococcus pneumoniae causes serious diseases such as pneumonia and meningitis. Its major pathogenic factor is the cholesterol-dependent cytolysin pneumolysin, which produces lytic pores at high concentrations.
Elke Maier, Fortsch, C., Mitchell, T.J., Benz, Roland, Ma, Jiangtao, Christina Förtsch, Sabrina Hupp, Jiangtao Ma, Timothy J. Mitchell, Iliev, A. I., Maier, Elke, Förtsch, Christina, Maier, E., Hupp, Sabrina, Asparouh I. Iliev, Hupp, S., Mitchell, Timothy J, Roland Benz, Wippel, C., Benz, R., Ma, J., Wippel, Carolin, Iliev, Asparouh I, Carolin Wippel   +23 more
core   +1 more source

Effect of recurrent invasive pneumococcal disease on serum anti-pneumolysin IgG titres in HIV infected adults. [PDF]

, 2009
We measured serum anti-pneumolysin IgG concentrations in a prospective cohort of 34 HIV infected adults who developed recurrent pneumococcal bacteraemia, and compared baseline levels with HIV positive and HIV negative control subjects that remained free ...
Gordon, Stephen B, Zijlstra, Ed E., Etuwewe, Onajite M., Etuwewe, Onajite M, Zijlstra, Ed E, Gordon, Stephen, Hollingshead, Susan, Tolmie, Helen, French, Neil, Gordon, Stephen B., Swann, Natalie, Faragher, Brian   +11 more
core   +1 more source

Glycyrol targets Pneumolysin (PLY) oligomerization to reduce Streptococcus pneumoniae toxicity. [PDF]

Front Pharmacol
Aim of the study Exploring the potential of glycyrol to reduce the invasiveness of Streptococcus pneumoniae (S. pneumoniae). Materials and Methods Cell experiments were performed using A549 alveolar epithelial cells and S. pneumoniae D39.
Li Y, Wu H, Hu Y, Meng H, Xu Y.
europepmc   +2 more sources