Results 11 to 20 of about 5,963 (243)

Neurotoxicity of Pneumolysin, a Major Pneumococcal Virulence Factor, Involves Calcium Influx and Depends on Activation of p38 Mitogen-Activated Protein Kinase

Neurobiology of Disease, 2002
Neuronal injury in bacterial meningitis is caused by the interplay of host inflammatory responses and direct bacterial toxicity. We investigated the mechanisms by which pneumolysin, a cytosolic pneumococcal protein, induces damage to neurons.
Timothy J Mitchell, Bernhard U Keller, Joachim Gerber   +2 more
exaly   +3 more sources

Impact of Endogenous Pneumococcal Hydrogen Peroxide on the Activity and Release of Pneumolysin

Toxins, 2023
Streptococcus pneumoniae is the leading cause of community-acquired pneumonia. The pore-forming cholesterol-dependent cytolysin (CDC) pneumolysin (PLY) and the physiological metabolite hydrogen peroxide (H2O2) can greatly increase the virulence of ...
Jasmin Bazant, Benjamin Ott, Martina Hudel, Torsten Hain, Rudolf Lucas, Mobarak Abu Mraheil   +5 more
doaj   +2 more sources

Biological Properties of Pneumolysin

Microbial Drug Resistance, 1997
ABSTRACT Pneumolysin is a thiol-activated membrane-damaging toxin produced by Streptococcus pneumoniae . The toxin plays a role in virulence of the pneumococcus in animal models of infection.
T J, Mitchell, P W, Andrew
openaire   +3 more sources

A comparison of pneumolysin activity and concentration in vitro and in vivo in a rabbit endophthalmitis model

Clinical Ophthalmology, 2008
Melissa E Sanders1, Erin W Norcross1, Quincy C Moore III1, Chinwendu Onwubiko1, Lauren B King1, et al1Department of Microbiology; 2Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USAAbstract: The purpose of this ...
Melissa E Sanders, Erin W Norcross, Quincy C Moore III, Chinwendu Onwubiko, Lauren B King, et al   +5 more
doaj   +1 more source

The Yin and Yang of Pneumolysin During Pneumococcal Infection

Frontiers in Immunology, 2022
Pneumolysin (PLY) is a pore-forming toxin produced by the human pathobiont Streptococcus pneumoniae, the major cause of pneumonia worldwide. PLY, a key pneumococcal virulence factor, can form transmembrane pores in host cells, disrupting plasma membrane integrity and deregulating cellular homeostasis. At lytic concentrations, PLY causes cell death.
Joana M. Pereira, Joana M. Pereira, Joana M. Pereira, Shuying Xu, Shuying Xu, John M. Leong, Sandra Sousa, Sandra Sousa   +7 more
openaire   +4 more sources

Hydrogen Peroxide Is Responsible for the Cytotoxic Effects of Streptococcus pneumoniae on Primary Microglia in the Absence of Pneumolysin

Journal of Innate Immunity
Introduction: Streptococcus pneumoniae is the most common cause of bacterial meningitis and meningoencephalitis in humans. The bacterium produces numerous virulence determinants; among them, hydrogen peroxide (H2O2) and pneumolysin (Ply) contribute to ...
Franziska Jennert, Désirée Schaaf, Roland Nau, Thomas P. Kohler, Sven Hammerschmidt, Darius Häusler, Peter Valentin-Weigand, Jana Seele   +7 more
doaj   +2 more sources

Neurotoxizität von Pneumolysin

, 2008
S. pneumoniae is one of the major keys in bacterial meningitis. Neurological sequelae are frequent and severe. The reason for it is apoptosis. Here we showed that Pneumolysin, a membrane binding and pore forming toxin of pneumococci plays an important role in triggering neuronal cell death of primary rat neurons in vitro.
Schickhaus, Miriam
openaire   +2 more sources

Protective role of Cav-1 in pneumolysin-induced endothelial barrier dysfunction

Frontiers in Immunology, 2022
Pneumolysin (PLY) is a bacterial pore forming toxin and primary virulence factor of Streptococcus pneumonia, a major cause of pneumonia. PLY binds cholesterol-rich domains of the endothelial cell (EC) plasma membrane resulting in pore assembly and ...
Robert K. Batori, Feng Chen, Zsuzsanna Bordan, Stephen Haigh, Yunchao Su, Alexander D. Verin, Alexander D. Verin, Scott A. Barman, David W. Stepp, David W. Stepp, Trinad Chakraborty, Rudolf Lucas, Rudolf Lucas, Rudolf Lucas, David J. R. Fulton, David J. R. Fulton   +15 more
doaj   +2 more sources

Procoagulant Activity of Blood and Microvesicles Is Disturbed by Pneumococcal Pneumolysin, Which Interacts with Coagulation Factors

Journal of Innate Immunity, 2022
The coagulation and contact systems are parts of the innate immune system as they prevent bleeding and dissemination of pathogens and also contribute to microbial killing by inflammatory reactions and the release of antimicrobial peptides.
Sonja Oehmcke-Hecht, Claudia Maletzki, Surabhi Surabhi, Nikolai Siemens, Valeria Khaimov, Lisa Marie John, Sina Mariella Peter, Sven Hammerschmidt, Bernd Kreikemeyer   +8 more
doaj   +2 more sources

Antibodies against polysaccharide type 3 and pneumococcal proteins demonstrate synergistic protective effect in a highly virulent type 3 invasive disease model in mice [PDF]

Frontiers in Immunology
Streptococcus pneumoniae serotype-3 (ST-3) continues to be a major contributor to pneumococcal disease burden despite its inclusion in multivalent pneumococcal conjugate vaccines (PCV).
Taylor C. Stevenson, Heidi Burke, Sara E. Roggensack, Anthony Pratt, Aquib Hossain, Pallab Ghosh, Gilles Besin, Yingjie Lu, Fan Zhang, Richard Malley, Shite Sebastian   +10 more
doaj   +2 more sources