Results 21 to 30 of about 5,963 (243)

A novel drug that reduces pneumococcal toxicity by targeting pneumolysin (PLY): efficacy of the traditional Chinese medicine Radix Paeoniae Alba [PDF]

Frontiers in Pharmacology
ObjectiveWhile existing virulence-targeting strategies predominantly rely on single-component inhibitors that exert evolutionary pressure, this study pioneers an innovative approach using the multicomponent traditional Chinese medicine Radix Paeoniae ...
Yan Xu, Jing Han, Jing Han, Yonglin Zhou, Liping Sun, Liping Sun   +5 more
doaj   +2 more sources

Measuring kinetic drivers of pneumolysin pore structure [PDF]

European Biophysics Journal, 2016
Most membrane attack complex-perforin/cholesterol-dependent cytolysin (MACPF/CDC) proteins are thought to form pores in target membranes by assembling into pre-pore oligomers before undergoing a pre-pore to pore transition. Assembly during pore formation is into both full rings of subunits and incomplete rings (arcs).
Gilbert, RJC, Sonnen, AFP
openaire   +5 more sources

Pneumolysin contributes to dysfunction of nasal epithelial barrier for promotion of pneumococcal dissemination into brain tissue

mSphere
Streptococcus pneumoniae is one of the major pathogens responsible for bacterial meningitis and neurological sequelae. The present study was conducted to identify a non-hematogenous route used by S.
Yuki Takahara, Tomoko Sumitomo, Masamitsu Kono, Moe Takemura, Yukako Akamatsu, Yujiro Hirose, Masaya Yamaguchi, Masanobu Nakata, Muneki Hotomi, Shigetada Kawabata   +9 more
doaj   +2 more sources

Magnetic Nanoclusters Increase the Sensitivity of Lateral Flow Immunoassays for Protein Detection: Application to Pneumolysin as a Biomarker for Streptococcus pneumoniae

Nanomaterials, 2022
Lateral flow immunoassays for detecting biomarkers in body fluids are simple, quick, inexpensive point-of-care tests widely used in disease surveillance, such as during the coronavirus disease 2019 (COVID-19) pandemic.
María Salvador, José Luis Marqués-Fernández, Alexander Bunge, José Carlos Martínez-García, Rodica Turcu, Davide Peddis, María del Mar García-Suárez, María Dolores Cima-Cabal, Montserrat Rivas   +8 more
doaj   +2 more sources

Structural and functional analogy between pneumolysin and proaerolysin [PDF]

Protein Engineering Design and Selection, 1997
Pneumolysin and proaerolysin are bacterial toxins that form pores in host cells by oligomerization. We propose that they may have similar structures despite a poor sequence identity. The crystal structure of proaerolysin reveals a protein composed of four domains, arranged in the shape of an elongated comma.
Sowdhamini, R, Mitchell, TJ, Andrew, PW, Morgan, PJ   +3 more
openaire   +4 more sources

Pneumolysin-dependent and independent non-canonical autophagy processes mediate host defense against pneumococcal infection. [PDF]

Autophagy
Streptococcus pneumoniae is an opportunistic pathogen responsible for life-threatening diseases including pneumonia and meningitis. The host defense against pneumococci relies heavily on macrophages, which can effectively internalize and degrade bacteria.
Michno BJ, Pooranachandran N, Smith TC, Faught E, Lipowská S, Fenton AK, Meijer AH, Prajsnar TK.   +7 more
europepmc   +3 more sources

Intracellularly Released Cholesterol from Polymer-Based Delivery Systems Alters Cellular Responses to Pneumolysin and Promotes Cell Survival

Metabolites, 2021
Cholesterol is highly abundant within all human body cells and modulates critical cellular functions related to cellular plasticity, metabolism, and survival.
Tobias Kammann, Jessica Hoff, Ilknur Yildirim, Blerina Shkodra, Tina Müller, Christine Weber, Markus H. Gräler, Ulrich A. Maus, James C. Paton, Mervyn Singer, Anja Traeger, Ulrich S. Schubert, Michael Bauer, Adrian T. Press   +13 more
doaj   +1 more source

Clarithromycin Inhibits Pneumolysin Production via Downregulation of ply Gene Transcription despite Autolysis Activation

Microbiology Spectrum, 2021
Streptococcus pneumoniae, the most common cause of community-acquired pneumonia, causes severe invasive infections, including meningitis and bacteremia. The widespread use of macrolides has been reported to increase the prevalence of macrolide-resistant ...
Hisanori Domon, Toshihito Isono, Takumi Hiyoshi, Hikaru Tamura, Karin Sasagawa, Tomoki Maekawa, Satoru Hirayama, Katsunori Yanagihara, Yutaka Terao   +8 more
doaj   +1 more source

Chlorogenic acid mitigates ferroptosis in macrophages induced by pneumolysin and streptococcus pneumoniae through activation of NRF2/GPX4 pathway. [PDF]

BMC Immunol
Drug-resistant Streptococcus pneumoniae (SP) infections pose a significant global health threat, with a limited availability of effective treatments to prevent disease progression.
Yang L, Yu D, Zhou H, Wang W, Wan H.
europepmc   +2 more sources

The Global Burden of Community-Acquired Pneumonia in Adults, Encompassing Invasive Pneumococcal Disease and the Prevalence of Its Associated Cardiovascular Events, with a Focus on Pneumolysin and Macrolide Antibiotics in Pathogenesis and Therapy

International Journal of Molecular Sciences, 2023
Despite innovative advances in anti-infective therapies and vaccine development technologies, community-acquired pneumonia (CAP) remains the most persistent cause of infection-related mortality globally.
R. Anderson, C. Feldman
semanticscholar   +1 more source