Glucose and Oxygen Levels Modulate the Pore-Forming Effects of Cholesterol-Dependent Cytolysin Pneumolysin from Streptococcus pneumoniae [PDF]
ToxinsA major Streptococcus pneumoniae pathogenic factor is the cholesterol-dependent cytolysin pneumolysin, binding membrane cholesterol and producing permanent lytic or transient pores.
Michelle Salomé Hoffet +4 more
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Analysis of Codon Usage Bias in the Streptococcus pneumoniae Pneumolysin Gene [PDF]
Canadian Journal of Infectious Diseases and Medical MicrobiologyStreptococcus pneumoniae pneumolysin is a key virulence factor belonging to the cholesterol-dependent cytolysin family, enabling host cell lysis and immune evasion.
Xiaochun Tan +5 more
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In vitro and in vivo evaluation of humanized monoclonal antibodies targeting pneumolysin [PDF]
Microbiology SpectrumStreptococcus pneumoniae is a gram-positive bacterium that causes a variety of diseases, including otitis media, sinusitis, pneumonia, bacteremia, and meningitis.
Lijun Song +6 more
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Incomplete pneumolysin oligomers form membrane pores [PDF]
Open Biology, 2014 Pneumolysin is a member of the cholesterol-dependent cytolysin (CDC) family of pore-forming proteins that are produced as water-soluble monomers or dimers, bind to target membranes and oligomerize into large ring-shaped assemblies comprising ...
Andreas F.-P. Sonnen +2 more
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Pneumolysin: Pathogenesis and Therapeutic Target [PDF]
Frontiers in Microbiology, 2020 Streptococcus pneumoniae is an opportunistic pathogen responsible for widespread illness and is a major global health issue for children, the elderly, and the immunocompromised population.
Andrew T. Nishimoto +2 more
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Pneumolysin boosts the neuroinflammatory response to Streptococcus pneumoniae through enhanced endocytosis [PDF]
Nature Communications, 2022 In pneumococcal meningitis, bacterial growth in the cerebrospinal fluid results in lysis, the release of toxic factors, and subsequent neuroinflammation.
Sabrina Hupp +4 more
semanticscholar +2 more sources
Proinflammatory Interactions of Pneumolysin with Human Neutrophils [PDF]
The Journal of Infectious Diseases, 2001 The effects of pneumolysin on the proinflammatory activity of human neutrophils, as well as on cation fluxes in these cells, have been investigated. Superoxide production, release of elastase, CR3 expression, phospholipase A2 activity, and alterations in membrane potential were measured by use of lucigenin-enhanced chemiluminescence and colorimetric ...
R, Cockeran +6 more
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Frontiers in Cellular and Infection Microbiology, 2023 IntroductionStreptococcus pneumoniae bacteria cause life-threatening invasive pneumococcal disease (IPD), including meningitis. Pneumococci are classified into serotypes, determined by differences in capsular polysaccharide and both serotype and ...
Annelies Müller +14 more
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Structural investigations of pneumolysin/lipid complexes [PDF]
Molecular Membrane Biology, 2000 Pneumolysin, a virulence factor from the human pathogen Streptococcus pneumoniae, is a water-soluble protein which forms ring-shaped oligomeric structures upon binding to cholesterol-containing lipid membranes. It induces vesicle aggregation, membrane pore formation and withdrawal of lipid material into non-bilayer proteolipid complexes.
Bonev, B, Gilbert, R, Watts, A
openaire +3 more sources
Fusion of PspA to detoxified pneumolysin enhances pneumococcal vaccine coverage.
PLoS ONE, 2023 Despite the implementation of conjugate vaccines in several countries, S. pneumoniae continues to pose a great burden worldwide, causing around 1 million annual deaths.
Barbara Milani +8 more
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