Results 41 to 50 of about 5,963 (243)

Immunoinformatics-aided design of a new multi-epitope vaccine adjuvanted with domain 4 of pneumolysin against Streptococcus pneumoniae strains

BMC Bioinformatics, 2023
Background Streptococcus pneumoniae (Pneumococcus) has remained a leading cause of fatal infections such as pneumonia, meningitis, and sepsis. Moreover, this pathogen plays a major role in bacterial co-infection in patients with life-threatening ...
Mona Shafaghi, Z. Bahadori, Hamid Madanchi, M. Ranjbar, A. Shabani, S. F. Mousavi   +5 more
semanticscholar   +1 more source

Bacterial cytolysin during meningitis disrupts the regulation of glutamate in the brain, leading to synaptic damage.

PLoS Pathogens, 2013
Streptococcus pneumoniae (pneumococcal) meningitis is a common bacterial infection of the brain. The cholesterol-dependent cytolysin pneumolysin represents a key factor, determining the neuropathogenic potential of the pneumococci.
Carolin Wippel, Jana Maurer, Christina Förtsch, Sabrina Hupp, Alexandra Bohl, Jiangtao Ma, Timothy J Mitchell, Stephanie Bunkowski, Wolfgang Brück, Roland Nau, Asparouh I Iliev   +10 more
doaj   +1 more source

Pneumolysin: stimulating protection [PDF]

Nature Reviews Microbiology, 2010
A new paper inPLoS Pathogens on Streptococcus pneumoniaepneumolysin provides the first example of the involvement of the NLRP3 inflammasome in protection against a Gram-positive bacterium.
openaire   +2 more sources

Pore-forming activity of S. pneumoniae pneumolysin disrupts the paracellular localization of the epithelial adherens junction protein E-cadherin

bioRxiv, 2023
Streptococcus pneumoniae, a common cause of community-acquired bacterial pneumonia, can cross the respiratory epithelial barrier to cause lethal septicemia and meningitis. S. pneumoniae pore-forming toxin pneumolysin (PLY) triggers robust neutrophil (PMN)
Shuying Xu, Devons Mo, F. Rizvi, Juan P. Rosa, Jorge Ruiz, Shumin Tan, R. Tweten, J. Leong, Walter Adams   +8 more
semanticscholar   +1 more source

Mapping of Recognition Sites of Monoclonal Antibodies Responsible for the Inhibition of Pneumolysin Functional Activity

Biomolecules, 2020
The pathogenicity of many bacteria, including Streptococcus pneumoniae, depends on pore-forming toxins (PFTs) that cause host cell lysis by forming large pores in cholesterol-containing cell membranes.
Indre Kucinskaite-Kodze, Martynas Simanavicius, Justas Dapkunas, Milda Pleckaityte, Aurelija Zvirbliene   +4 more
doaj   +1 more source

Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. [PDF]

, 2012
Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal.
Mitchell, T.J., Timothy J. Mitchell (150478), Moira K. B. Whyte (150482), David H. Dockrell (114218), Read Robert C., Daigneault, Marc, Daigneault Marc, De Silva, T.I., Helen M. Marriott (150472), De Silva Thushan I., Marriott, Helen M, Preston, Julie A, Dockrell, David H, Marriott, H.M., Julie A Preston, Thushan I. De Silva, De Silva, Thushan I., Dockrell, David H., Whyte, M.K.B., Martin A. Bewley, Preston, Julie A., Mitchell Timothy J., Andrea M. Mitchell, Timothy J Mitchell, Whyte, Moira K B, Mitchell Andrea M., Thushan I. De Silva (150466), Moira K. B. Whyte, Preston Julie A., Helen M Marriott, Preston, J.A., Martin A. Bewley (150467), Robert C Read, Bewley, M.A., Marc Daigneault (150463), Marc Daigneault, Dockrell, D.H., Mitchell, Andrea M; id_orcid, Whyte Moira K. B., Whyte, Moira K. B., Marriott Helen M., Mitchell, Andrea M., Read, Robert C., Robert C. Read (145234), De Silva, Thushan I, Mitchell, Timothy J., Read, R.C., David H. Dockrell, Julie A. Preston (150469), Andrea M. Mitchell (150475), Mitchell, Timothy J, David H Dockrell, Moira K B Whyte, Marriott, Helen M., Mitchell, A.M., Timothy J. Mitchell, Andrea M Mitchell, Bewley, Martin A, Daigneault, M., Read, Robert C, Robert C. Read, Dockrell David H., Bewley, Martin A., Martin A Bewley, Helen M. Marriott, Julie A. Preston, Dockrell, David, Bewley Martin A., Thushan I De Silva   +68 more
core   +1 more source

The Importance of Pore-Forming Toxins in Multiple Organ Injury and Dysfunction

Biomedicines, 2022
Background: Multiple organ injury and dysfunction often occurs in acute critical illness and adversely affects survival. However, in patients who survive, organ function usually recovers without permanent damage.
Simon T. Abrams, Lijun Wang, Jun Yong, Qian Yu, Min Du, Yasir Alhamdi, Zhenxing Cheng, Caroline Dart, Steven Lane, Weiping Yu, Cheng-Hock Toh, Guozheng Wang   +11 more
doaj   +1 more source

Changes in Astrocyte Shape Induced by Sublytic Concentrations of the Cholesterol-Dependent Cytolysin Pneumolysin Still Require Pore-Forming Capacity

Toxins, 2011
Streptococcus pneumoniae is a common pathogen that causes various infections, such as sepsis and meningitis. A major pathogenic factor of S. pneumoniae is the cholesterol-dependent cytolysin, pneumolysin. It produces cell lysis at high concentrations and
Christina Förtsch, Roland Benz, Asparouh I. Iliev, Jiangtao Ma, Timothy J. Mitchell, Elke Maier, Sabrina Hupp   +6 more
doaj   +1 more source

Export Requirements of Pneumolysin in Streptococcus pneumoniae [PDF]

Journal of Bacteriology, 2012
ABSTRACT Streptococcus pneumoniae is a major causative agent of otitis media, pneumonia, bacteremia, and meningitis. Pneumolysin (Ply), a member of the cholesterol-dependent cytolysins (CDCs), is produced by virtually all clinical isolates of S.
Katherine E, Price, Neil G, Greene, Andrew, Camilli   +2 more
openaire   +2 more sources

Distinct Neurotoxicity Profile of Listeriolysin O from Listeria monocytogenes

Toxins, 2017
Cholesterol-dependent cytolysins (CDCs) are protein toxins that originate from Gram-positive bacteria and contribute substantially to their pathogenicity. CDCs bind membrane cholesterol and build prepores and lytic pores.
Jana Maurer, Sabrina Hupp, Carolin Bischoff, Christina Foertsch, Timothy J. Mitchell, Trinad Chakraborty, Asparouh I. Iliev   +6 more
doaj   +1 more source