Results 61 to 70 of about 5,963 (243)

Pneumolysin and the bacterial capsule of Streptococcus pneumoniae cooperatively inhibit taxis and motility of microglia

Journal of Neuroinflammation, 2019
Background Streptococcus pneumoniae is the cause of a highly lethal form of meningitis in humans. Microglial cells in the brain represent the first line of defense against pathogens, and they participate in the inflammatory response.
Sabrina Hupp, Denis Grandgirard, Timothy J. Mitchell, Stephen L. Leib, Lucy J. Hathaway, Asparouh I. Iliev   +5 more
doaj   +1 more source

Demonstration of Virulence Factors in Streptococcus Pneumoniae Isolates from a Tertiary Hospital in South India [PDF]

National Journal of Laboratory Medicine, 2017
Introduction: Streptococcus pneumoniae (pneumococci) colonizes the nasopharynx and 94 different serotypes have been characterized on the basis of the capsular polysaccharides.
Jayashree Veerasamy, Jayalakshmi Jayarajan   +1 more
doaj   +1 more source

Pneumolysin mediates platelet activationin vitro [PDF]

10.1 Respiratory Infections, 2016
This study has explored the role of the pneumococcal toxin, pneumolysin (Ply), in activating human platelets. Following exposure to Ply (10-80 ng/ml), platelet activation and cytosolic Ca(2+) concentrations were measured flow cytometrically according to the level of expression of CD62P (P-selectin) and spectrofluorimetrically, respectively. Exposure to
Nel, Jan Gert, Durandt, Chrisna, Mitchell, Timothy J., Feldman, Charles, Anderson, Ronald, Tintinger, Gregory Ronald   +5 more
openaire   +3 more sources

Detoxified pneumolysin derivative ΔA146Ply inhibits triple- negative breast cancer metastasis mainly via mannose receptor-mediated autophagy inhibition

Virulence, 2023
The detoxified pneumolysin derivative ΔA146Ply has been proven to have a direct anti-triple negative breast cancer effect by our group, but its work model remains unclear.
Hong Zhang, Tao Zhu, Wenchun Xu, Bichen Liu, Kai-feng Wu, Yibing Yin, Xuemei Zhang   +6 more
semanticscholar   +1 more source

Glycyrrhetinic acid reduces lung inflammation caused by pneumococcal infection by reducing the toxicity of pneumolysin. [PDF]

Heliyon
Objective In this study, to provide new methods for the treatment of Streptococcus pneumoniae infection, we aimed to describe the anti-inflammatory and antibacterial value of glycyrrhetinic acid on the basis of its inhibitory effect on bacterial growth ...
Xu Y, Ding Y, Wu H, Li D, Li Y, Hu Y, Meng H.   +6 more
europepmc   +2 more sources

A conserved tryptophan in pneumolysin is a determinant of the characteristics of channels formed by pneumolysin in cells and planar lipid bilayers [PDF]

Biochemical Journal, 1998
Pneumolysin is one of the family of thiol-activatable, cytolytic toxins. Within these toxins the amino acid sequence Trp-Glu-Trp-Trp is conserved. Mutations made in this region of pneumolysin, residues 433-436 inclusive, did not affect cell binding or the formation of toxin oligomers in the target cell membrane.
Y E, Korchev, C L, Bashford, C, Pederzolli, C A, Pasternak, P J, Morgan, P W, Andrew, T J, Mitchell   +6 more
openaire   +2 more sources

Pneumolysin promotes host cell necroptosis and bacterial competence during pneumococcal meningitis as shown by whole-animal dual RNA-seq

bioRxiv, 2022
Pneumolysin is a major virulence factor of Streptococcus pneumoniae that plays a key role in interaction with the host during invasive disease. How pneumolysin influences these dynamics between host and pathogen interaction during early phase of central ...
K. K. Jim, Rieza Aprianto, Arnau Domenech, Jun Kurushima, D. van de Beek, C. Vandenbroucke-Grauls, W. Bitter, J. Veening   +7 more
semanticscholar   +1 more source

Hsp70 Suppresses Mitochondrial Reactive Oxygen Species and Preserves Pulmonary Microvascular Barrier Integrity Following Exposure to Bacterial Toxins

Frontiers in Immunology, 2018
Pneumonia is a leading cause of death in children and the elderly worldwide, accounting for 15% of all deaths of children under 5 years old. Streptococcus pneumoniae is a common and aggressive cause of pneumonia and can also contribute to meningitis and ...
Xueyi Li, Yanfang Yu, Yanfang Yu, Boris Gorshkov, Stephen Haigh, Zsuzsanna Bordan, Daniel Weintraub, Radu Daniel Rudic, Trinad Chakraborty, Scott A. Barman, Alexander D. Verin, Yunchao Su, Rudolf Lucas, Rudolf Lucas, David W. Stepp, Feng Chen, Feng Chen, David J. R. Fulton, David J. R. Fulton   +18 more
doaj   +1 more source

Electrochemical Detection for Isothermal Loop-Mediated Amplification of Pneumolysin Gene of Streptococcus pneumoniae Based on the Oxidation of Phenol Red Indicator

Analytical Chemistry, 2022
A highly sensitive electrochemical methodology for end-point detection of loop-mediated isothermal nucleic acid amplification reactions was developed. It is based on the oxidation process of phenol red (PR), commonly used as a visual indicator.
A. González-López, M. D. Cima-Cabal, P. Rioboó-Legaspi, E. Costa-Rama, M. M. García-Suárez, M. Fernández-Abedul   +5 more
semanticscholar   +1 more source

Adenosine Triphosphate Neutralizes Pneumolysin-induced Neutrophil Activation.

, 2020
Background: In tissue infections, adenosine triphosphate (ATP) is released into extracellular space and contributes to purinergic chemotaxis. Neutrophils are important players in bacterial clearance and recruited to the site of tissue infections ...
Cuypers, Fabian, Burchhardt, Gerhard, Surabhi, Surabhi, Thiele, Thomas, Hammerschmidt, Sven, Klabunde, Björn, Rohde, Manfred, Skorka, Sebastian B, Siemens, Nikolai, Gesell Salazar, Manuela, Michalik, Stephan, Völker, Uwe   +11 more
core   +1 more source