Results 91 to 100 of about 5,963 (243)

Synthetic Cells on Demand: From Molecular Stimuli to Cellular Functions

ChemSystemsChem, Volume 8, Issue 2, March 2026.
ABSTRACT Synthetic cells constructed via bottom‐up approaches using lipid or polymer vesicles have become essential tools for mimicking cellular functions and studying synthetic biological systems. These vesicles can undergo morphological changes and trigger internal reactions in response to external stimuli, such as osmotic pressure, temperature, pH ...
Masato Suzuki, Koki Kamiya
wiley   +1 more source

Alnustone inhibits Streptococcus pneumoniae virulence by targeting pneumolysin and sortase A

bioRxiv, 2022
Streptococcus pneumoniae (S. pneumoniae) is a significant Gram-positive opportunistic pathogen responsible for a variety of lethal infections. This bacterium accounts for more deaths from diseases than any other single pathogen worldwide.
Canbin Zhang, Xinyu Wang, Linlin Shi, Baihe Zhan, Nana Hou, Suohong Liu, Manjie Bao, Gefu Chi, T. Fang   +8 more
semanticscholar   +1 more source

Neuronal death in pneumococcal meningitis is triggered by pneumolysin and RrgA interactions with β-actin

PLoS Pathogens, 2021
Neuronal damage is a major consequence of bacterial meningitis, but little is known about mechanisms of bacterial interaction with neurons leading to neuronal cell death.
Mahebali Tabusi, Sigrun Thorsdottir, Maria Lysandrou, A. R. Narciso, M. Minoia, Chinmaya V Srambickal, J. Widengren, B. Henriques‐Normark, F. Iovino   +8 more
semanticscholar   +1 more source

Repeat Intraocular Sampling and Microbiological Testing in Infectious Endophthalmitis: A 27‐Year Prospective Observational Study at an Australian Statewide Tertiary Referral Centre

Clinical &Experimental Ophthalmology, Volume 54, Issue 1, Page 44-54, January/February 2026.
ABSTRACT Background Endophthalmitis requiring multiple ocular tissue sampling for microbiological testing is uncommon and has not been previously studied. This study aims to analyse cases with at least two ocular tissue samplings and testing of different ocular samples against culture yields. Methods A 27‐year prospective observational study using data
Pravena Kumaran, Maedbh Rhatigan, Zelia Chiu, Jasmine Lichtenstein, Penelope J. Allen, Rosie C. H. Dawkins   +5 more
wiley   +1 more source

Multifaceted Small Molecules as Enzyme Modulators: Cases of Drug Discovery/Repurposing Illustrating Nature′s Pragmatism

BioMed Research International, Volume 2026, Issue 1, 2026.
The cross‐reactivity of substrates, modulators with other enzymes significantly reduces/prevents our ability to design such highly specific, that is, “one warhead–one target”, modulators. On the other hand, the potential “impasse” fuels repurposing of already developed drugs.
Monika I. Konaklieva, Balbina J. Plotkin, Nahit Gencer   +2 more
wiley   +1 more source

A fusion protein comprising pneumococcal surface protein A and a pneumolysin derivate confers protection in a murine model of pneumococcal pneumonia

PLoS ONE, 2022
PspA and pneumolysin are two important vaccine candidates, able to elicit protection in different models of pneumococcal infection. The high immunogenic potential of PspA, combined with a possible adjuvant effect of pneumolysin derivatives (due to their ...
T. W. Dos Santos, Pedro Goncalves, D. Rodriguez, J. A. Pereira, C. Martinez, L. Leite, L. Ferraz, T. R. Converso, M. Darrieux   +8 more
semanticscholar   +1 more source

Streptococcus pneumoniae evades human dendritic cell surveillance by pneumolysin expression [PDF]

, 2009
Dendritic cells (DCs) protect the respiratory epithelium via induction of innate immune responses and priming of naive T cells during the initiation of adaptive immunity.
Frentzen, Anne, Henriques-Normark, Birgitta, Marie Littmann, Laura Plant, Albiger, Barbara, Staffan Normark, Barbara Albiger, Albiger, Barbara,, Normark, Staffan, Littmann, Marie, Anne Frentzen, Lund University., Plant, Laura, Birgitta Henriques‐Normark   +13 more
core   +1 more source

Epithelial Sodium Channel-α Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction

Frontiers in Immunology, 2017
BackgroundStreptococcus pneumoniae is a major etiologic agent of bacterial pneumonia. Autolysis and antibiotic-mediated lysis of pneumococci induce release of the pore-forming toxin, pneumolysin (PLY), their major virulence factor, which is a prominent ...
Istvan Czikora, Abdel A. Alli, Abdel A. Alli, Supriya Sridhar, Michael A. Matthay, Helena Pillich, Martina Hudel, Besim Berisha, Boris Gorshkov, Maritza J. Romero, Maritza J. Romero, Joyce Gonzales, Guangyu Wu, Yuqing Huo, Yuqing Huo, Yunchao Su, Alexander D. Verin, Alexander D. Verin, David Fulton, David Fulton, Trinad Chakraborty, Douglas C. Eaton, Rudolf Lucas, Rudolf Lucas, Rudolf Lucas   +24 more
doaj   +1 more source

Construction and protective efficacy of a novel Streptococcus pneumoniae fusion protein vaccine NanAT1-TufT1-PlyD4

Frontiers in Immunology, 2022
During the past decades, with the implementation of pneumococcal polysaccharide vaccine (PPV) and pneumococcal conjugate vaccines (PCVs), a dramatic reduction in vaccine type diseases and transmissions has occurred.
Yali Cui, Yali Cui, Chenglin Miao, Wen Chen, Wen Chen, Wenling Shang, Qianqian Qi, Wei Zhou, Wei Zhou, Xia Wang, Xia Wang, Yingying Li, Yingying Li, Ziyi Yan, Ziyi Yan, Yongmei Jiang, Yongmei Jiang   +16 more
doaj   +1 more source

Detoxified pneumolysin derivative ΔA146Ply inhibits autophagy and induces apoptosis in acute myeloid leukemia cells by activating mTOR signaling

Experimental and Molecular Medicine, 2022
Leukemia is caused by the malignant clonal expansion of hematopoietic stem cells, and in adults, the most common type of leukemia is acute myeloid leukemia (AML). Autophagy inhibitors are often used in preclinical and clinical models in leukemia therapy.
Tao Zhu, Hong Zhang, Sijie Li, Kai-feng Wu, Yibing Yin, Xuemei Zhang   +5 more
semanticscholar   +1 more source