Results 81 to 90 of about 1,746,086 (317)

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Sputum Induction in Children Is Feasible and Useful in a Bustling General Hospital Practice [PDF]

, 2016
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The Jeroen Bosch Hospital funded this study.Peer reviewedPublisher ...
Bart, Ingeborg Y., de Vries, Esther, Hilbink, Mirrian, Mourits, Mariëlle, van Gent, René, van Leuken, Maarten H., Warris, Adilia, Wever, Peter C.   +7 more
core   +1 more source

Treatment with Plasma Activated (Salt) Water Sterilizes Macromolecular Coatings While Maintaining Their Integrity and Functionality

Advanced Materials Interfaces, EarlyView.
PDMS samples were covalently coated with mucin glycoproteins and then treated with either plasma activated water (PAW) or saline (PAS) as a means of disinfection. The samples could be successfully sterilized without compromising the structural integrity or functionality of those coatings.
Bernardo Miller Naranjo, Markus Ahrens, Ádám Nemes, Petra Mela, Oliver Lieleg   +4 more
wiley   +1 more source

Preliminary Analysis of the Anti-biofilm Efficacy of Manuka Honey on Extended Spectrum Β-lactamase Producing Escherichia Coli Tem-3 and Klebsiella Pneumoniae Shv18, Associated with Urinary Tract Infections [PDF]

, 2019
open access articleUrinary Tract Infections (UTIs) are one of the most common infections in the UK and many other parts of the world. The prevalence of the Extended Spectrum β-Lactamases (ESBLs) producing UTIs, combined with their ability to form a bio ...
Baho, S., Czapnik, Paulina, Samarasinghe, S.   +2 more
core  

Increased mortality in hematological malignancy patients with acute respiratory failure from undetermined etiology : a Groupe de Recherche en Réanimation Respiratoire en Onco-Hématologique (Grrr-OH) study [PDF]

, 2016
Background: Acute respiratory failure (ARF) is the most frequent complication in patients with hematological malignancies and is associated with high morbidity and mortality.
Azoulay, Elie, Benoit, Dominique, Bruneel, Fabrice, Contejean, Adrien, Darmon, Michael, Hamidfar, Rebecca, Jourdain, Mercé, Kouatchet, Achille, Lemiale, Virginie, Mayaux, Julien, Meert, Anne-Pascale, Mokart, Djamel, Nyunga, Martine, Perez, Pierre, Pène, Frédéric, Rabbat, Antoine, Renault, Anne, Resche-Rigon, Matthieu, Schlemmer, Benoît, Vincent, François   +19 more
core   +2 more sources

Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia

Nature Medicine, 2018
Lung-innervating nociceptor sensory neurons detect noxious or harmful stimuli and consequently protect organisms by mediating coughing, pain, and bronchoconstriction. However, the role of sensory neurons in pulmonary host defense is unclear.
P. Baral, Benjamin D. Umans, Lu Li, Antonia Wallrapp, Meghna Bist, Talia Kirschbaum, Yibing Wei, Yan Zhou, V. Kuchroo, Patrick R. Burkett, B. Yipp, S. Liberles, I. Chiu   +12 more
semanticscholar   +1 more source

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

Advanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li, Kang Wang, Wenzhuang Shi, Xu Wang, Duxin Li, Yanli Liu, Peng Zhang, Yipeng Wang   +7 more
wiley   +1 more source

Community-acquired pneumonia in children: cell-free plasma sequencing for diagnosis and management. [PDF]

, 2019
Community-acquired pneumonia (CAP) is a common cause of pediatric hospital admission. Empiric antibiotic therapy for hospitalized children with serious CAP now targets the most likely pathogen(s), including those that may demonstrate significant ...
Bradley, John S, Cannavino, Christopher R, Coufal, Nicole G, Farnaes, Lauge, Foley, Jennifer, Hong, David K, Pong, Alice, Ryan Loker, Kathleen, Wilke, Julianne   +8 more
core  

Evidence-Based Study Design for Hospital-Acquired Bacterial Pneumonia and Ventilator-Associated Bacterial Pneumonia

Journal of Infectious Diseases, 2019
BACKGROUND The US Food and Drug Administration solicited evidence-based recommendations to improve guidance for studies of hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP).
G. Talbot, Anita F. Das, Stephanie S. Cush, A. Dane, M. Wible, R. Echols, A. Torres, S. Cammarata, J. Rex, J. Powers, T. Fleming, J. Loutit, S. Hoffmann   +12 more
semanticscholar   +1 more source

Neural Circuits between Nodose Ganglion and Pulmonary Neuroendocrine Cells Regulate Lung Inflammatory Responses

Advanced Science, EarlyView.
TRPA1+αCGRP+ sensory neurons in the nodose ganglion detect external insults such as lipopolysaccharide (LPS) and interact directly with pulmonary neuroendocrine cells (PNECs), promoting their activation and proliferation. This neural‐epithelial interaction amplifies lung inflammation.
Jie Chen, Shitao Xie, Zhekai Lin, Caiqi Zhao, Rujia Tao, Yingying Ma, Xiaoyan Chen, Renlan Wu, Qingjian Han, Pengfei Sui, Sheng Wang, Hongbin Ji, Hai Song, Xiaoming Zhang, Yangang Sun, Yuanlin Song, Xiao Su   +16 more
wiley   +1 more source