Results 81 to 90 of about 1,205,800 (294)

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Diagnostic and prognostic value of serum HBP combined with PCT, CRP, and SAA in early-stage pneumonia

Virology Journal
Objective To assess the diagnostic efficacy of serum heparin-binding protein (HBP) as a standalone biomarker and in combination panels for distinguishing early-stage bacterial from viral pneumonia, and to explore its prognostic value in predicting ...
Pengju Cao, Songgao Zhang, Jiangang Huang, Wanru Dai   +3 more
doaj   +1 more source

Neutrophil-lymphocyte ratio as a point-of-care marker for predicting bacterial etiology in pediatric community-acquired Pneumonia: A comparative analysis with C -reactive protein

Clinical Epidemiology and Global Health
Objectives: To evaluate the role of NLR in predicting bacterial etiology in pediatric community acquired pneumonia and compare its diagnostic performance with CRP.
Maya Lakshmanan, Sandeep Kumar, Sowmya Shashidhara, Pushpa Kini, Shrikiran Aroor, Suneel Mundkur, Ramesh Bhat Y, Karen Moras   +7 more
doaj   +1 more source

The role of statins in prevention and treatment of community acquired pneumonia: a systematic review and meta-analysis. [PDF]

, 2013
BACKGROUND: Emerging epidemiological evidence suggests that statins may reduce the risk of community-acquired pneumonia (CAP) and its complications. PURPOSE: Performed a systematic review to address the role of statins in the prevention or treatment ...
Imad M Tleyjeh, Khan Abdur Rahman, Mohamad A. Al-Tannir (104241), Imad M. Tleyjeh (104252), Tleyjeh, I. M., Patricia J Erwin, Muhammad Riaz, Abdur Rahman Khan (104234), Garbati, MA, Muhammad Riaz (104236), Bin Abdulhak, AA, Bin Abdulhak Aref A., Erwin, PJ, Baddour, LM, Riaz Muhammad, Musa A Garbati, Aref A. Bin Abdulhak (5648656), Patricia J. Erwin (104246), Abdur Rahman Khan, Al-Tannir Mohamad A., Riaz, M., Khan, AR, Al-Tannir, MA, Tleyjeh, IM, Erwin Patricia J., Larry M Baddour, Baddour Larry M., Khan, A. R., Garbati, M. A., Garbati Musa A., Al-Tannir, M. A., Larry M. Baddour (104249), Riaz, M, Aref A Bin Abdulhak, Mohamad A Al-Tannir, Bin Abdulhak, A. A., Tleyjeh Imad M., Erwin, P. J., Baddour, L. M., Musa A. Garbati (104244)   +39 more
core   +1 more source

A STUDY ON CAPRINE PNEUMONIA IN IRAQI LOCAL GOATS ETIOLOGICAL FINDINGS

The Iraqi Journal of Veterinary Medicine, 1989
In a study designed to evaluate the prevalence of caprine pneumonia and to identify it's bacterial and parasitic causes, 100 lungs with pneumonic lesions were collected. The prevalence rate was 12.5%. The most commonly associated bacterial isolates with
K. H. Al-Joboury , A. M. Al-Darraji
doaj   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Comparison of Minimally Invasive Colectomy Between Intra‐ Versus Extra‐Corporeal Anastomosis Technique (COMMIT Study): Short‐Term Analysis

Annals of Gastroenterological Surgery, EarlyView.
This multicenter propensity score‐matched study of 3213 patients compared intracorporeal (IA) and extracorporeal (EA) anastomosis during minimally invasive colectomy. IA was associated with a significantly lower incidence of intraoperative blood loss ≥ 200 mL (2.5% vs.
Takuya Takami, Takehito Yamamoto, Yoshiro Itatani, Ryosuke Mizuno, Kae Okoshi, Yasunori Deguchi, Keiji Nagata, Tomoaki Okada, Rei Mizuno, Kazutaka Obama   +9 more
wiley   +1 more source

Impact of Postoperative Infectious Complications on Long‐Term Survival After Curative Resection for Colorectal Cancer: A Multicenter Study in the Minimally Invasive Era

Annals of Gastroenterological Surgery, EarlyView.
Postoperative infectious complications (PICs) have been associated with poor long‐term outcomes after colorectal cancer surgery, but evidence in the modern minimally invasive era remains limited. In this multicenter cohort of 5377 patients undergoing curative resection, PICs were independently associated with worse overall survival and relapse‐free ...
Takehito Yamamoto, Ryosuke Mizuno, Yoshiro Itatani, Tetsuya Shiota, Masahiro Yamada, Tadayoshi Yamaura, Mami Yoshitomi, Kazutaka Obama   +7 more
wiley   +1 more source

Signs and symptoms indicative of community-acquired pneumonia in infants under six months

Brazilian Journal of Infectious Diseases
OBJECTIVE: Evaluation of the clinical signs and symptoms predicting bacterial and viral pneumonia, in accordance with the Brazilian National Control Program for Acute Respiratory (ARI). METHODS: Observational prospective study.
Maria de Fátima Bazhuni Pombo March, Clemax Couto Sant'Anna   +1 more
doaj   +1 more source

Bacterial Co-Infections and Antimicrobial Resistance in Patients Hospitalized with Suspected or Confirmed COVID-19 Pneumonia in Kazakhstan

, 2023
Our study was carried out to characterize respiratory tract microbiota in patients with “COVID-like pneumonia” in Kazakhstan and analyze differences between COVID-19 positive and negative groups.
Irina Kadyrova, Anar Turmukhambetova, Alyona Lavrinenko, Svetlana Kolesnichenko, Dmitriy Klyuyev, Lyudmila Akhmaltdinova   +5 more
core   +1 more source