Results 51 to 60 of about 214,009 (223)

Continued control of pneumococcal disease in the UK - the impact of vaccination

, 2011
Streptococcus pneumoniae, also known as the pneumococcus, is an important cause of morbidity and mortality in the developed and developing world. Pneumococcal conjugate vaccines were first introduced for routine use in the USA in 2000, although the seven-
Gladstone, R.A., Jefferies, J.M., Gladstone, R.A, S. N. Faust, Faust, S.N, Faust, S.N ., R. A. Gladstone, Clarke, S.C., J. M. Jefferies, Jefferies, J.M, Clarke, S.C, S. C. Clarke   +11 more
core   +1 more source

C-reactive protein is essential for innate resistance to pneumococcal infection. [PDF]

, 2014
No deficiency of human C-reactive protein (CRP), or even structural polymorphism of the protein, has yet been reported so its physiological role is not known.
Lawrence, Rachel A., Read, Kevin D., Aviva Petrie, Pepys, M B, Pepys, MB, Hutchinson, Winston L., LSHTM, Read, Kevin D, Raynes, JG, Read, KD, J. Brian Souza, Tennent, G A, Stephan Ellmerich, Loeffler, JM, Simons, JP, Rachel A. Lawrence, Simons, J Paul, Tennent, GA, John G. Raynes, Dundee, Glenys A. Tennent, Ellmerich, Stephan, Ellmerich, S, Tennent, Glenys A, Al-Shawi, Raya, Petrie, A, Tennent, Glenys A., Simons, J. Paul, Lawrence, R A, Jutta M. Loeffler, Lawrence, RA, Hutchinson, Winston L, J. Paul Simons, de Souza, J Brian, de Souza, J. Brian, Kevin D. Read, Raynes, John G., Raynes, J G, Read, K D, Mark B. Pepys, Hutchinson, WL, de Souza, JB, Loeffler, Jutta M, Petrie, Aviva, Al-Shawi, R, Pepys, Mark B., Lawrence, Rachel A, Raynes, John G, Loeffler, J M, de Souza, J B, Hutchinson, W L, Pepys, Mark B, Raya Al‐Shawi, Winston L. Hutchinson, Loeffler, Jutta M., Simons, J P, UCL   +56 more
core   +1 more source

The anticipated severity of a "1918-like" influenza pandemic in contemporary populations: the contribution of antibacterial interventions. [PDF]

PLoS ONE, 2012
Recent studies have shown that most of deaths in the 1918 influenza pandemic were caused by secondary bacterial infections, primarily pneumococcal pneumonia.
Yu-Wen Chien, Bruce R Levin, Keith P Klugman   +2 more
doaj   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis. [PDF]

, 2009
During acute bacterial infections such as meningitis, neutrophils enter the tissue where they combat the infection before they undergo apoptosis and are taken up by macrophages.
Häcker Georg, Bianca Obermaier, Georg Häcker, Robert Paul, Hans Häcker, Obermaier, Bianca, Paul Robert, Frankenberg, Tobias, Koedel, Uwe, Uwe Koedel, Frankenberg Tobias, Paul, Robert, Susanne Kirschnek, Kirschnek, Susanne, Tobias Frankenberg, Kirschnek Susanne, Obermaier Bianca, Koedel Uwe, Häcker, Hans, Häcker, Georg, Häcker Hans   +20 more
core   +2 more sources

MicroRNA-223 Dampens Pulmonary Inflammation during Pneumococcal Pneumonia

Cells, 2023
Community-acquired pneumonia remains a major contributor to global communicable disease-mediated mortality. Neutrophils play a leading role in trying to contain bacterial lung infection, but they also drive detrimental pulmonary inflammation, when ...
Cengiz Goekeri, Peter Pennitz, Wibke Groenewald, Ulrike Behrendt, Holger Kirsten, Christian M. Zobel, Sarah Berger, Gitta A. Heinz, Mir-Farzin Mashreghi, Sandra-Maria Wienhold, Kristina Dietert, Anca Dorhoi, Achim D. Gruber, Markus Scholz, Gernot Rohde, Norbert Suttorp, CAPNETZ Study Group, Martin Witzenrath, Geraldine Nouailles   +18 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Enhancing Evidence Generation by Linking Randomized Clinical Trials to Real‐World Data: The INVESTED‐Medicare Linkage Study

Clinical Pharmacology &Therapeutics, EarlyView.
Real‐world evidence (RWE) derived from real‐world data (RWD) can complement randomized controlled trials (RCTs), yet the validity of RWD relative to RCT data remains insufficiently characterized. We obtained post hoc consent and linked individual participant data from the US‐based INVESTED trial (2016–2019) with Medicare fee‐for‐service claims (2012 ...
Hanseul Cho, HoJin Shin, Mehdi Najafzadeh, Brian Claggett, Janinne Ortega‐Montiel, Jun Liu, Julie M. Paik, Narlina F. Lalani, Marie C. Bradley, John Concato, Scott D. Solomon, Orly Vardeny, Elisabetta Patorno   +12 more
wiley   +1 more source

Biomarkers and bacterial pneumonia risk in patients with treated HIV infection: a case-control study [PDF]

, 2013
Background: Despite advances in HIV treatment, bacterial pneumonia continues to cause considerable morbidity and mortality in patients with HIV infection. Studies of biomarker associations with bacterial pneumonia risk in treated HIV-infected patients do
Kunisaki, KM, Brian Angus, Gordin, Fred M., Sarah L Pett, Angus, Brian, Bjerk, Sonja M., Sonja M. Bjerk, Sean Emery, Kunisaki, Ken M, Neuhaus, Jacqueline, Ken M Kunisaki, Jacqueline Neuhaus, Ristola, M., Baker, Jason V., Gordin, FM, Pett, Sarah L, Jason V Baker, Pett, Sarah L., Neuhaus, J, Sonja M Bjerk, Stephan, C, Baker, Jason V, Fred M Gordin, Christoph Stephan, Gordin, Fred M, Bjerk, Sonja M, INSIGHT SMART Study Group, Kunisaki, Ken M., Fred M. Gordin, Stephan, Christoph, Casseb, Jorge Simão do Rosário, Bjerk, SM, Ken M. Kunisaki, Emery, S, Angus, B, Sarah L. Pett, Jason V. Baker, Emery, Sean, Baker, JV, Pett, SL   +39 more
core   +1 more source

A model for predicting bacteremia in patients with community-acquired pneumococcal pneumonia: a retrospective observational study

BMC Pulmonary Medicine, 2018
Background Pneumococcal pneumonia causes high morbidity and mortality among adults. This study aimed to identify risk factors for bacteremic pneumococcal pneumonia, and to construct a prediction model for the development of bacteremia in patients with ...
Yasuyoshi Washio, Akihiro Ito, Shogo Kumagai, Tadashi Ishida, Akio Yamazaki   +4 more
doaj   +1 more source