Results 71 to 80 of about 392,151 (262)

Elucidating the impact of the pneumococcal conjugate vaccine programme on pneumonia, sepsis and otitis media hospital admissions in England using a composite control

BMC Medicine, 2018
BackgroundThe seven-valent pneumococcal conjugate vaccine (PCV) was introduced in England in September 2006, changing to the 13-valent vaccine in April 2010.
D. Thorrington, N. Andrews, J. Stowe, E. Miller, A. V. van Hoek   +4 more
semanticscholar   +1 more source

A model for predicting bacteremia in patients with community-acquired pneumococcal pneumonia: a retrospective observational study

BMC Pulmonary Medicine, 2018
Background Pneumococcal pneumonia causes high morbidity and mortality among adults. This study aimed to identify risk factors for bacteremic pneumococcal pneumonia, and to construct a prediction model for the development of bacteremia in patients with ...
Yasuyoshi Washio, Akihiro Ito, Shogo Kumagai, Tadashi Ishida, Akio Yamazaki   +4 more
doaj   +1 more source

Pathogenesis and prevention of risk of cardiovascular events in patients with pneumococcal community‐acquired pneumonia

Journal of Internal Medicine, 2019
It is now well recognized that cardiovascular events (CVE) occur quite commonly, both in the acute phase and in the long‐term, in patients with community‐acquired pneumonia (CAP).
C. Feldman, S. Normark, B. Henriques-Normark, R. Anderson   +3 more
semanticscholar   +1 more source

Challenges to estimating vaccine impact using hospitalization data. [PDF]

, 2017
Because the real-world impact of new vaccines cannot be known before they are implemented in national programs, post-implementation studies at the population level are critical.
Bruhn, Christian AW, Kürüm, Esra, Lustig, Roger, Schuck-Paim, Cynthia, Simonsen, Lone, Taylor, Robert J, Weinberger, Daniel M   +6 more
core   +3 more sources

Clinically Relevant Model of Pneumococcal Pneumonia, ARDS, and Non-Pulmonary Organ Dysfunction in Mice.

American Journal of Physiology - Lung cellular and Molecular Physiology, 2019
Pneumonia is responsible for more deaths in the United States than any other infectious disease. Severe pneumonia is a common cause of acute respiratory failure and the Acute Respiratory Distress Syndrome (ARDS).
J. Gotts, Olivier Bernard, L. Chun, R. Croze, James T. Ross, N. Nesseler, Xueling Wu, J. Abbott, Xiaohui Fang, C. Calfee, M. Matthay   +10 more
semanticscholar   +1 more source

A Trial of a 7-Valent Pneumococcal Conjugate Vaccine in HIV-Infected Adults. [PDF]

, 2010
BACKGROUND: Streptococcus pneumoniae is a leading and serious coinfection in adults with human immunodeficiency virus (HIV) infection, particularly in Africa.
French, N, Gilks, CF, Gordon, SB, Longwe, H, Molyneux, ME, Mwafulirwa, G, Mwaiponya, M, Mwalukomo, T, White, SA, Zijlstra, EE   +9 more
core   +2 more sources

Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin [PDF]

, 2020
Streptococcus pneumoniae serotype 1 is the predominant cause of invasive pneumococcal disease in sub-Saharan Africa, but the mechanism behind its increased invasiveness is not well understood.
Baltazar, Murielle, Bricio-Moreno, Laura, Dowson, Christopher G., Everett, Dean B., Jacques, Laura C., Kadioglu, Aras, Khandaker, Shadia, Neill, Daniel R., Panagiotou, Stavros, Senghore, Madikay, Xu, Rong, Yang, Marie   +11 more
core   +3 more sources

Reduction in respiratory mortality not associated with influenza in Russia: effect of the introduction of pneumococcal vaccination (PCV13), or improvement in care? [PDF]

arXiv, 2020
Background. Pneumococcal vaccination (PCV13) for children (as well as older adults) in Russia was introduced in 2014, with no prior PCV7 use. While pneumonia hospitalization rates, both in children and adults did not decrease in the following years, respiratory mortality rates did decline with time.
arxiv  

Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia

Frontiers in Immunology, 2018
Excessive activation of neutrophils results in the release of neutrophil elastase (NE), which leads to lung injury in severe pneumonia. Previously, we demonstrated a novel immune subversion mechanism involving microbial exploitation of this NE ability ...
H. Domon, K. Nagai, T. Maekawa, M. Oda, Daisuke Yonezawa, Wataru Takeda, Takumi Hiyoshi, Hikaru Tamura, M. Yamaguchi, S. Kawabata, Y. Terao   +10 more
semanticscholar   +1 more source

Occupationally Relevant Zinc‐ and Copper‐Containing Metal Fumes Inhibit Human THP‐1 Macrophage TNF and IL‐6 Responses to Bacterial Stimuli

Global Challenges, EarlyView.
Metal workers have an increased risk of severe pneumonia due to metal fume exposure. In this study, zinc oxide (ZnO) and copper oxide (CuO) particles are found to inhibit specific anti‐bacterial macrophage responses, which may substantially contribute to impaired lung immunity.
Jan Steffens, Sabrina Michael, Katharina Kuth, Henner Hollert, Miriam Du Marchie Sarvaas, Andrijana Nesic, Thomas Kraus, Ralf Baumann   +7 more
wiley   +1 more source