Cellular mRNAs access second ORFs using a novel amino acid sequence-dependent coupled translation termination-reinitiation mechanism [PDF]
, 2014 Polycistronic transcripts are considered rare in the human genome. Initiation of translation of internal ORFs of eukaryotic genes has been shown to use either leaky scanning or highly structured IRES regions to access initiation codons.
Croft, Wayne D. +4 more
core +1 more source
Viruses, 2018 Prevention of severe lower respiratory tract infections in infants caused by the human respiratory syncytial virus (hRSV) remains a major public health priority. Currently, the major focus of vaccine development relies on the RSV fusion (F) protein since
Annelies Leemans +12 more
doaj +1 more source
Cloned defective interfering influenza virus protects ferrets from pandemic 2009 influenza A virus and allows protective immunity to be established [PDF]
, 2012 Influenza A viruses are a major cause of morbidity and mortality in the human population, causing epidemics in the winter, and occasional worldwide pandemics.
Carroll, Miles W. +9 more
core +12 more sources
Avian Metapneumovirus Review: A Focus on Broilers [PDF]
Poultry Science Journal, 2023 Avian Metapneumovirus infection first emerged in South African turkeys, followed by respiratory problems in chickens with a swollen head syndrome. The etiological agent is a Metapneumovirus in the Pneumoviridae family and the first pneumovirus identified
Amine Mernizi +6 more
doaj +1 more source
Prevalence and clinical symptoms of human metapneumovirus infection in hospitalized patients [PDF]
, 2003 During a 17-month period, we performed retrospective analyses of the prevalence of and clinical symptoms associated with human metapneumovirus (hMPV) infection, among patients in a university hospital in The Netherlands.
Beyer, W.E.Ph. (Walter) +7 more
core +2 more sources
Glucocorticoid Administration Accelerates Mortality of PneumovirusâInfected Mice [PDF]
The Journal of Infectious Diseases, 2001 The use of glucocorticoids for the treatment of symptoms associated with respiratory syncytial virus (RSV) infection has been questioned. To evaluate the sequelae of glucocorticoid administration in the setting of pneumovirus infection in vivo, hydrocortisone was administered to mice infected with pneumonia virus of mice (PVM), a pneumovirus and ...
J B, Domachowske +5 more
openaire +2 more sources
The Changing Landscape of Respiratory Syncytial Virus Infections
Pathogens, 2023 Respiratory syncytial virus (RSV), a negative-sense, enveloped RNA virus of the family Paramyxoviridae, subfamily Pneumovirinae, and genus Pneumovirus, is the single most important respiratory pathogen affecting infants and young children [...]
Reinout A. Bem, Job B. M. van Woensel
doaj +1 more source
Viruses, 2022 Human respiratory syncytial virus (hRSV) infection brings a wide spectrum of clinical outcomes, from a mild cold to severe bronchiolitis or even acute interstitial pneumonia. Among the known factors influencing this clinical diversity, genetic background
Gautier Gilliaux, Daniel Desmecht
doaj +1 more source
A comparison of AMPV subtypes A and B full genomes, gene transcripts and proteins led to reverse-genetics systems rescuing both subtypes [PDF]
, 2016 Avian metapneumovirus (AMPV) infection of poultry causes serious disease in most countries and subtype A reverse-genetic (RG) systems have allowed a generation of viruses of known sequence, and proved useful in developments towards better control by live
Catelli, Elena +7 more
core +1 more source
Host Cell Restriction Factors of Paramyxoviruses and Pneumoviruses
Viruses, 2020 The paramyxo- and pneumovirus family includes a wide range of viruses that can cause respiratory and/or systemic infections in humans and animals. The significant disease burden of these viruses is further exacerbated by the limited therapeutics that are
Rubaiyea Farrukee +4 more
doaj +1 more source