Results 121 to 130 of about 47,146 (309)

Nrf2‐Mediated Ferroptosis Is Involved in Berberine‐Induced Alleviation of Diabetic Kidney Disease

Phytotherapy Research, EarlyView.
ABSTRACT Diabetic kidney disease (DKD) is the most common and serious complication of diabetes mellitus. Currently, there is a lack of safe and effective preventive strategies for DKD. The study aimed to explore the preventive effects and potential mechanisms of berberine (BBR) against DKD.
Kun Gao, Yunhua Liu, Kun Li, Lin Liu, Yanmo Cai, Xinxue Zhang, Zongjiang Zhao   +6 more
wiley   +1 more source

Development of a Novel Diagnostic Test Using Podocyturia as a Biomarker for Detection of Kidney Damage [PDF]

, 2013
Primary glomerular diseases are the most common cause of progressive chronic kidney disease (CKD) in dogs, a common and significant source of illness that often progresses to kidney failure.
Farooqi, Eesha
core   +1 more source

Mitochondrial dynamics in autoimmune diseases

Rheumatology &Autoimmunity, EarlyView.
Roles of mitochondrial dynamic imbalance in autoimmune diseases. The imbalance of mitochondrial fusion and fission is involved in the occurrence and development of autoimmune diseases, including systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, type 1 diabetes, psoriasis, and autoimmune ...
Ruicong Ma, Cheng Zhang, Jiaqing Liu, Jinyi Ren, Xia Li, Ying Zhao   +5 more
wiley   +1 more source

Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses

Cell Reports
Summary: Signal-regulatory protein alpha (SIRPα) has recently been found to be highly expressed in podocytes and is essential for maintaining podocyte function. However, its immunoregulatory function in podocytes remains elusive.
Bin Qian, Rui Lu, Shuya Mao, Yang Chen, Miao Yang, Wenxuan Zhang, Mingchao Zhang, Dihan Zhu, Zhihong Liu, Ke Zen, Limin Li   +10 more
doaj   +1 more source

Idiopathic nodular glomerulosclerosis in a chronic marijuana user; a case report and review of the literature [PDF]

, 2017
Background: Nodular glomerulosclerosis is a characteristic histological finding of diabetic nephropathy (DN) with thickened glomerular basement membrane (GBM) and hyalinized arterioles.
Abdul Salim, Sohil, Fülöp, Tibor, Hamrahian, Seyed Mehrdad, Mollaee, Mehri   +3 more
core   +2 more sources

Extracellular vesicles derived from silicate‐stimulated antler reserve mesenchymal cells alleviate kidney damage in diabetic nephropathy through inhibiting abnormal angiogenesis and apoptosis

VIEW, EarlyView.
A novel bioengineering platform was invented to harness simple silicate ions to command highly regenerative deer antler cells, transforming them into super‐factories that massively produce customized extracellular vesicles (Si‐RM‐EVs) rich in therapeutic miR‐148a‐3p, dwarfing natural EV output and payload.
Pengfei Hu, Zhaowenbin Zhang, Dongxu Wang, Xiuying Li, Jiping Li, Jinchi Ying, Tiantian Jiang, Chen Zhao, Jiang Chang, Chunyi Li   +9 more
wiley   +1 more source

Characterization of novel glomerular proteins : role in physiology and disease [PDF]

, 2014
Glomerular damage accounts for the majority of chronic kidney disease cases, the prevalence of which is dramatically escalating worldwide, mainly due to increase in diabetes and associated nephropathy.
Andersson, Ann-Charlotte
core   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

CD36-Mediated Lipid Accumulation and Activation of NLRP3 Inflammasome Lead to Podocyte Injury in Obesity-Related Glomerulopathy

Mediators of Inflammation, 2019
Podocyte injury critically contributes to the pathogenesis of obesity-related glomerulopathy (ORG). Recently, lipid accumulation and inflammatory responses have been found to be involved in podocyte injury.
Jing Zhao, Hong-liang Rui, Min Yang, Li-jun Sun, Hong-rui Dong, Hong Cheng   +5 more
doaj   +1 more source

Gα12 Activation in Podocytes Leads to Cumulative Changes in Glomerular Collagen Expression, Proteinuria and Glomerulosclerosis [PDF]

, 2012
Glomerulosclerosis is a common pathologic finding that often progresses to renal failure. The mechanisms of chronic kidney disease progression are not well-defined but may include activation of numerous vasoactive and inflammatory pathways.
Beaudry, Sarah, Boucher, Ilene, Denker, Bradley M., Henderson, Joel, Negoro, Hideyuki, Pollak, Martin, Tran, Mei, Yu, Wanfeng   +7 more
core   +1 more source