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Triptolide Protects Podocytes from Injury
2014Triptolide, a diterpene triepoxide, possesses potent anti-inflammatory and immunosuppressive properties and provides protection in the experimental models of various glomerular diseases. Clinical studies have also shown that triptolide is therapeutically effective in podocytopathies, including membranous nephropathy, focal segmental glomerulosclerosis ...
Weisong Qin, Zhi-Hong Liu
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Glomerular podocytic injury in protein overload proteinuria
Pathology, 1985Injection of rats with large doses of bovine serum albumin causes proteinuria which may persist long after the period of overload has ended. In order to assess in this model of proteinuria the relative importance of podocytic epithelial changes versus alterations in anionic groups in the glomerular capillary wall a morphological study has been made of ...
D J, Davies +3 more
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Cell Cycle and Podocyte Injury
2014Background: The cell cycle is regulated by cyclins activating cyclin-dependent kinases (Cdk). Cdk inhibitors bind to and inhibit cyclin-Cdk complexes.
Henning Hagmann +2 more
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Podocyte injury and targeting therapy: an update
Current Opinion in Nephrology & Hypertension, 2006Podocyte injury is a central event in the development of glomerulosclerosis. This review highlights contributions from the past year to our understanding of mechanisms of podocyte injury and implications for potential treatment strategies of glomerular disease.Rearrangement of the actin cytoskeleton, the backbone linking the slit diaphragm, apical ...
Raghu V, Durvasula, Stuart J, Shankland
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Podocyte Injury and Glomerulosclerosis in Hyperhomocysteinemic Rats
American Journal of Nephrology, 2007<i>Background/Aims:</i> We previously reported that increase in plasma homocysteine (Hcys) levels by a 6-week methionine treatment produced remarkable glomerular injury. However, the mechanism by which hyperhomocysteinemia (hHcys) produces glomerular injury remains unknown.
Fan, Yi +5 more
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Knocking down Cabin1 induces glomerular podocyte injury
International Urology and Nephrology, 2018Podocyte damage exerts a key role in proteinuria. We have demonstrated that calcineurin-binding protein 1 (Cabin1) upregulated during podocyte injury, yet its function in podocyte is still unclear.We established 5/6 nephrectomized rats and angiotensin II (AngII)-injured podocyte, as well as knocked down Cabin1 with siRNA in cultured podocytes.
Yueqiang, Wen +6 more
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BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury
American Journal of Physiology-Renal Physiology, 2007In early diabetic renal injury, there is podocyte drop-out (but no decrease in the number of other glomerular cells) which is thought to cause glomerular proteinuria and subsequent diabetic glomerular injury. We tested the hypothesis that early diabetic podocyte injury is caused, in part, by downregulation of bone morphogenetic protein-7 (BMP7) and ...
Grace M, Mitu +2 more
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Role of Podocyte Injury in IgA Nephropathy
2013IgA nephropathy (IgAN) encompasses different pathological entities, all of which are characterized by the mesangial deposition of IgA. Aberrantly glycosylated IgA molecules appear to play a major role in the pathogenesis of IgAN. Both genetic and environmental factors contribute to the formation of IgG antibodies that binds to aberrantly glycosylated ...
Madhav C, Menon +2 more
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[Podocyte injury and glomerular sclerosis].
Nihon rinsho. Japanese journal of clinical medicine, 2004Recently, our understanding of podocytes has been greatly advanced by genetic analysis of human kidney diseases and corresponding animal models, establishment of podocyte cell lines, and discovery of podocyte specific promoters that facilitate transgenic research.
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METTL3-mediated m6A modification of TIMP2 mRNA promotes podocyte injury in diabetic nephropathy
Molecular Therapy, 2022Ling Jiang, Li Gao, Xiao-ming Meng
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