Results 121 to 130 of about 50,846 (317)

Current Progress of Tissue Engineering With Stem Cells in Urology Updated Review in 2025

International Journal of Urology, EarlyView.
ABSTRACT Tissue engineering, a key component of regenerative medicine, aims to restore the structure and function of damaged organs using combinations of cells, scaffolds, and bioactive factors. In urology, the integration of stem cell biology has fueled significant progress in preclinical models for kidney, bladder, and urethral regeneration ...
Kenichi Kobayashi, Tsunehito Horii, Akinori Wada, Kazuaki Yamanaka, Akeo Hagiwara, Susumu Kageyama   +5 more
wiley   +1 more source

Glomerular endothelial derived vesicles mediate podocyte dysfunction: A potential role for miRNA.

PLoS ONE, 2020
MicroRNAs (miRNA) are shown to be involved in the progression of several types of kidney diseases. Podocytes maintain the integrity of the glomerular basement membrane.
N Hill, D L Michell, M Ramirez-Solano, Q Sheng, C Pusey, K C Vickers, K J Woollard   +6 more
doaj   +1 more source

Phosphorylation of nephrin induces phase separated domains that move through actomyosin contraction [PDF]

, 2019
© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Kim, S., Kalappurakkal, J. M., Mayor, S., & Rosen, M. K.
Kalappurakkal, Joseph Mathew, Kim, Soyeon, Mayor, Satyajit, Rosen, Michael K.   +3 more
core   +1 more source

The integrin repertoire drives YAP-dependent epithelial:stromal interactions during injury of the kidney glomerulus

Nature Communications
The kidney glomerulus is a filtration barrier in which capillary loop architecture depends on epithelial-stromal interactions between podocytes and mesangial cells.
Evelyne Huynh-Cong, Victoria Driscoll, Sandrine Ettou, Keith Keller, Amha Atakilit, Mary E. Taglienti, Saurabh Kumar, Astrid Weins, Valerie A. Schumacher, Jordan A. Kreidberg   +9 more
doaj   +1 more source

Dach1 is essential for maintaining normal mature podocytes.

PLoS ONE
Dach1 is highly expressed in normal podocytes, but this expression rapidly disappears after podocyte injury. To investigate the role of Dach1 in podocytes in vivo, we analyzed global, podocyte-specific, and inducible Dach1 knockout mice.
Keiko Tanaka, Haruko Hayasaka, Taiji Matsusaka   +2 more
doaj   +1 more source

Gα12 Activation in Podocytes Leads to Cumulative Changes in Glomerular Collagen Expression, Proteinuria and Glomerulosclerosis [PDF]

, 2012
Glomerulosclerosis is a common pathologic finding that often progresses to renal failure. The mechanisms of chronic kidney disease progression are not well-defined but may include activation of numerous vasoactive and inflammatory pathways.
Beaudry, Sarah, Boucher, Ilene, Denker, Bradley M., Henderson, Joel, Negoro, Hideyuki, Pollak, Martin, Tran, Mei, Yu, Wanfeng   +7 more
core   +1 more source

Expression of uPAR in Urinary Podocytes of Patients with Fabry Disease

International Journal of Nephrology, 2017
Background. Despite enzyme replacement therapy, Fabry nephropathy still progresses. Podocyturia is an irreversible event that antedates proteinuria and leads to chronic renal failure.
Hernán Trimarchi, Romina Canzonieri, Amalia Schiel, Juan Politei, Cristian Costales-Collaguazo, Aníbal Stern, Matías Paulero, Tatiana Rengel, Lara Valiño-Rivas, Mariano Forrester, Fernando Lombi, Vanesa Pomeranz, Romina Iriarte, Alexis Muryan, Alberto Ortiz, María Dolores Sanchez-Niño, Elsa Zotta   +16 more
doaj   +1 more source

mTOR blockade prevents progressive proteinuria but induces hyperglycaemia in obese Dahl salt‐sensitive rats before puberty

Experimental Physiology, EarlyView.
Abstract Previous studies have demonstrated that mammalian target of rapamycin (mTOR) activity is significantly increased in the kidneys of Dahl salt‐sensitive (SS) rats during the development of renal injury. Therefore, in the present study we examined whether blockade of mTOR with rapamycin inhibits renal injury in Dahl salt‐sensitive leptin receptor
Sautan Mandal, Andrea K. Brown, Ubong S. Ekperikpe, Anukool A. Bhopatkar, Krystle M. Hughes, Tyler D. Johnson, Jonita S. Cooper, Konnor T. Wilbert, Denise C. Cornelius, Jan M. Williams   +9 more
wiley   +1 more source

Assessment of podocyte detachment as a pivotal step in the development of focal segmental glomerulosclerosis

Journal of the Egyptian National Cancer Institute
Background Podocytopenia refers to a decrease in the number of podocytes. When podocytes are injured, they may detach leading to podocytopenia, which represents a critical step in the development of podocytopathy and subsequently deterioration of renal ...
Ikbal Ahmed Abdo Elkholy, Wagdi Elkashef, Fatma El-Husseini Mostafa, Amany Hassan   +3 more
doaj   +1 more source

Columbianetin protects from high-glycemic podocyte damage by regulating autophagy

Linchuang shenzangbing zazhi, 2021
Objective To explore the protective effect of columbianetin（CBT）on the injury of podocytes induced by high glucose and its mechanism.Methods Immortalized murine foot cell line MPC-5 was cultured in vitro and the effects of CBT on injury and autophagy ...
Shi Lang, Song Zhi-xia, Zhang Ya-fei
doaj