Results 121 to 130 of about 68,048 (352)

ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling [PDF]

, 2013
Nephrotic syndrome (NS) is divided into steroid-sensitive (SSNS) and -resistant (SRNS) variants. SRNS causes end-stage kidney disease, which cannot be cured.
Antignac, Bodo B. Beck, Bugsu Ovunc, Christian Faul, Corinne Antignac, Dominik S. Schoeb, Edgar A. Otto, Friedhelm Hildebrandt, Gil Chernin, Hanan M. Fathy, Heike Goebel, Heon Yung Gee, Hildebrandt, Humphrey Fang, Jeffrey W. Innis, Joseph Washburn, Julia Hoefele, Katrina A. Diaz, Lutz T. Weber, Neveen A. Soliman, Olivier Gribouval, Pawaree Saisawat, Roger C. Wiggins, Saleem, Shawn Levy, Shazia Ashraf, Sivakumar Natarajan, Svjetlana Lovric, Toby W. Hurd, Virginia Vega-Warner, Weibin Zhou, Wong, Yaacov Frishberg, Zhe Han   +33 more
core   +2 more sources

Protecting Podocytes: A Key Target for Therapy of Focal Segmental Glomerulosclerosis

American Journal of Nephrology, 2018
Background: Focal segmental glomerulosclerosis (FSGS) is a histologic pattern of injury demonstrated by renal biopsy that can arise from a diverse range of causes and mechanisms.
K. Campbell, J. Tumlin
semanticscholar   +1 more source

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, Accepted Article.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify non‐invasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, The LN classification steering committee   +11 more
wiley   +1 more source

Effects of a novel ANLN E841K mutation associated with SRNS on podocytes and its mechanism [PDF]

, 2023
Li Lin, Yuhong Ye, Haidong Fu, Weizhong Gu, Manli Zhao, Jingmiao Sun, Zhongkai Cao, Guoping Huang, Yi Xie, Fei Liu, Lu Li, Qiuyu Li, Jianhua Mao, Lidan Hu   +13 more
openalex   +1 more source

5‐Methylcytosine Analysis of miRNAs in Minimal Change Disease

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Huiyi Zeng, Dandan Li, Yunyi Li, Chen Yun, Xinzhou Zhang, Wenyu Gong, Mengyun Xiao, Haitao Li, Zhipeng Zeng, Ruqi Tan, Yishen Yang, Shaodong Luan, Yong Dai, Lianghong Yin, Donge Tang   +14 more
wiley   +1 more source

Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis [PDF]

, 2017
IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored.
Cisek, Katryna, Delles, Christian, Filip, Szymon, Gakiopoulou, Chara, Jankowski, Joachim, Krochmal, Magdalena, Markoska, Katerina, Mischak, Harald, Orange, Clare, Spasovski, Goce, Vlahou, Antonia, Zoidakis, Jerome   +11 more
core   +2 more sources

Finerenone according to insulin resistance in heart failure: Insights from the FINEARTS‐HF trial

European Journal of Heart Failure, EarlyView.
Insulin resistance in heart failure with mildly reduced or preserved ejection fraction: insights from FINEARTS‐HF. CI, confidence interval; CV, cardiovascular; eGDR, estimated glucose disposal rate; HF, heart failure. Aims The estimated glucose disposal rate (eGDR) is a simple, non‐invasive measure of insulin resistance. In this exploratory analysis of
John W. Ostrominski, Brian L. Claggett, Akshay S. Desai, Pardeep S. Jhund, Carolyn S.P. Lam, Michele Senni, Sanjiv J. Shah, Adriaan A. Voors, Faiez Zannad, Bertram Pitt, Katja Rohwedder, Meike Brinker, Patrick Schloemer, John J.V. McMurray, Scott D. Solomon, Muthiah Vaduganathan   +15 more
wiley   +1 more source

MicroRNA-770-5p contributes to podocyte injury via targeting E2F3 in diabetic nephropathy [PDF]

Brazilian Journal of Medical and Biological Research
Diabetic nephropathy (DN) has been identified as the major cause of end-stage renal disease (ESRD) in most developed countries. MicroRNA-770-5p depletion could repress high glucose (HG)-triggered apoptosis in podocytes, and downregulation of E2F ...
Juanjuan Guo, Jie Han, Jieying Liu, Shaoli Wang   +3 more
doaj   +2 more sources

Differential Expression Of Gap Junction mRNAs And Proteins In The Developing Murine Kidney And In Experimentally Induced Nephric Mesenchymes [PDF]

, 1992
The expression of three gap junction (GJ) proteins, alpha-1 (Cx43), beta-1 (Cx32), and beta-2 (Cx26), and their transcripts were examined during the ontogeny of the mouse and rat kidney. These proteins were expressed in two non-overlapping patterns.
Gilbert, Scott F., Gilula, N. B., Kumar, N. M., Lehtonen, E., Nishi, M., Sainio, K., Saxen, L.   +6 more
core   +1 more source

The 13th International Podocyte Conference [PDF]

, 2022
Silke R. Brix, Durga Kanigicherla, Dean Wallace, Tejas Desai, Rachel Lennon   +4 more
openalex   +1 more source