Results 131 to 140 of about 68,048 (352)
European Journal of Heart Failure, EarlyView.Pathophysiologic mechanisms of heart failure (HF) (i.e. renin–angiotensin–aldosterone system [RAAS], congestion, and inflammation), together with patient‐related factors such as diabetes, hypertension, and chronic kidney disease (CKD), contribute to kidney function decline and glomerular or tubular injury.
Masatake Kobayashi +14 more
wiley +1 more source
Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms [PDF]
, 2016 Diabetes mellitus (DM) is the major cause of end-stage renal disease (ESRD) globally, and novel treatments are urgently needed. Current therapeutic approaches for diabetic nephropathy (DN) are focussing on blood pressure control with inhibitors of the ...
Coward, RJ, Gnudi, L, Long, DA
core +1 more source
Differentiation of human iPSCs into functional podocytes
PLoS ONE, 2018 Podocytes play a critical role in glomerular barrier function, both in health and disease. However, in vivo terminally differentiated podocytes are difficult to be maintained in in vitro culture.
C. Rauch +9 more
semanticscholar +1 more source
The Role of the Podocyte in Preeclampsia [PDF]
Clinical Journal of the American Society of Nephrology, 2014 Preeclampsia is a pregnancy-specific hypertensive disorder that affects approximately 5% of pregnancies and remains one of the leading causes of both maternal and fetal morbidity and mortality worldwide ([1][1]).
openaire +2 more sources
iMeta, EarlyView.A clinical study reported that Abelmoschus manihot (L.) Medic (A. manihot), in the form of Huangkui capsule (HKC), combined with irbesartan (IRB) is an effective therapy for patients with diabetic kidney disease (DKD). The bioactive components of HKC are total flavones extracted from A. manihot (TFA).
Chenhua Wu +7 more
wiley +1 more source
Podocyte stress and detachment measured in urine are related to mean arterial pressure in healthy humans [PDF]
, 2020 Abhijit S. Naik +8 more
openalex +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT IgA nephropathy (IgAN), the most common form of glomerulonephritis, is a major and growing public health issue. It results from intestinal barrier dysfunction that leads to mesangial deposition of pathogenic galactose‐deficient IgA1 (Gd‐IgA1) and renal inflammation.
Meng‐Si Li, Kai Liu
wiley +1 more source
Insulin Increases Expression of TRPC6 Channels in Podocytes by a Calcineurin-Dependent Pathway
Cellular Physiology and Biochemistry, 2016 Background/Aims: Insulin signaling to podocytes is relevant for the function of the glomerulus. Now, we tested the hypothesis that insulin increases the surface expression of canonical transient receptor potential canonical type 6 (TRPC6) channels in ...
Shengqiang Xia +4 more
doaj +1 more source
Alterations of podocytes in a murine model of crescentic glomerulonephritis [PDF]
, 2018 Recent observations suggest a central role of podocytes in crescent formation. In experimental glomerulonephritis podocytes disrupt the parietal epithelial layer and attach on its basement membrane, thus forming bridges between the tuft and Bowman's ...
Besse-Eschmann, Valérie +3 more
core
Innate Immune Activity in Glomerular Podocytes [PDF]
, 2017 Glomerular podocytes are specialized in structure and play an essential role in glomerular filtration. In addition, podocyte stress can initiate glomerular damage by inducing the injury of other glomerular cell types.
Hong Xia, Shaolin Shi, Wenduona Bao
core +1 more source