Results 131 to 140 of about 50,846 (317)
Producing Purer Podocytes [PDF]
Journal of the American Society of Nephrology, 2019 Podocytes are highly specialized cells that play a central role in many renal disorders. For many years, podocyte research has been stymied by an inability to culture these cells in a well differentiated state.
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Experimental Physiology, EarlyView.Abstract IgA nephropathy (IgAN) is a common type of primary glomerulonephritis in children. The pathogenesis of childhood IgAN remains unclear, and there is a lack of effective non‐invasive biomarkers for this disease. Single‐cell RNA sequencing was performed in children with IgAN to delineate cellular and molecular compositions, and subcluster ...
Ling Yu +7 more
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Under the right conditions: protecting podocytes from diabetes-induced damage [PDF]
, 2013 Hyperglycemia-induced damage to the glomerular podocyte is thought to be a critical early event in diabetic nephropathy. Interventions that prevent podocyte damage or loss have been shown to have potential for the treatment of diabetic nephropathy.
Ali, Imran HA, Brazil, Derek P.
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The Journal of Physiology, EarlyView.Abstract figure legend Sodium thiosulfate (STS) rescues the pronephros phenotype of pdx1 morphants through compensatory upregulation of nitric oxide (NO) metabolism. Zebrafish larvae injected with a control morpholino show the typical pronephros structure at 48 h post‐fertilization (hpf) with and without STS treatment.
Hannes Ott +6 more
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Primary Coenzyme Q10 Deficiency [PDF]
, 2017 open4siCLINICAL CHARACTERISTICS: Primary coenzyme Q10 (CoQ10) deficiency is usually associated with multisystem involvement, including neurologic manifestations such as fatal neonatal encephalopathy with hypotonia; a late-onset slowly progressive ...
Doimo, Mara +3 more
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ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling [PDF]
, 2013 Nephrotic syndrome (NS) is divided into steroid-sensitive (SSNS) and -resistant (SRNS) variants. SRNS causes end-stage kidney disease, which cannot be cured.
Antignac +33 more
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Counting glomeruli in human kidney specimens using ex vivo MRI without contrast agents
Magnetic Resonance in Medicine, Volume 94, Issue 6, Page 2519-2528, December 2025.Abstract Purpose The total number of glomeruli is an important indicator of kidney function and susceptibility to disease. Glomeruli, however, are difficult to image using MRI without contrast enhancement. For this reason, previous studies have used cationic ferritin as a contrast agent to detect glomeruli in ex vivo and in vivo perfused kidneys.
Nyoman D. Kurniawan +11 more
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Inhalation of mercury vapor can cause the toxic effects on rat kidney [PDF]
, 2016 Dental amalgam has been used in dentistry as a filling material. The filler comprises mercury (Hg). It is considered one of the most important and widespread environmental pollutants, which poses a serious potential threat for the humans and animals ...
Akgul, Hayati Murat +5 more
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Taking Down the Primary Cilium: Pathways for Disassembly in Differentiating Cells
BioEssays, Volume 47, Issue 11, November 2025.Primary cilia are developmentally essential subcellular signaling compartments. However, many differentiated cells lack primary cilia, and cilia disassembly in these tissue contexts has been largely overlooked. We highlight several pathways for primary cilia loss and examine how changes in ciliation states could contribute to diverse pathologies ...
Carolyn M. Ott, Saikat Mukhopadhyay
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Progressive renal failure—inability of podocytes to replicate and the consequences for development of glomerulosclerosis [PDF]
, 1996 Wilhelm Kriz
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