Results 231 to 240 of about 34,405 (271)
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Current Opinion in Rheumatology, 2019
Purpose of review Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus and is characterized by proteinuria and renal failure. Proteinuria is a marker of poor prognosis and is attributed to podocyte loss and dysfunction.
Rhea, Bhargava, George C, Tsokos
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Purpose of review Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus and is characterized by proteinuria and renal failure. Proteinuria is a marker of poor prognosis and is attributed to podocyte loss and dysfunction.
Rhea, Bhargava, George C, Tsokos
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Current Opinion in Nephrology and Hypertension, 2009
The glomerular filtration barrier is a unique structure characterized by a specialized three-dimensional framework of podocytes. This review is aimed at describing the latest advances made in the understanding of polarity signalling pathways regulating the formation and the maintenance of the complex podocyte architecture.Podocytes are composed of a ...
Simons, Matias +2 more
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The glomerular filtration barrier is a unique structure characterized by a specialized three-dimensional framework of podocytes. This review is aimed at describing the latest advances made in the understanding of polarity signalling pathways regulating the formation and the maintenance of the complex podocyte architecture.Podocytes are composed of a ...
Simons, Matias +2 more
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Current Opinion in Nephrology and Hypertension, 2001
Knowledge of podocyte biology is growing rapidly. Podocytes are crucially involved in most hereditary diseases affecting the glomerulus, which all exhibit podocyte-specific defects, that is, foot process effacement and protein leakage. Efforts to understand molecular mechanisms causing these derangements are increasingly successful and will allow a ...
K, Endlich, W, Kriz, R, Witzgall
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Knowledge of podocyte biology is growing rapidly. Podocytes are crucially involved in most hereditary diseases affecting the glomerulus, which all exhibit podocyte-specific defects, that is, foot process effacement and protein leakage. Efforts to understand molecular mechanisms causing these derangements are increasingly successful and will allow a ...
K, Endlich, W, Kriz, R, Witzgall
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TGFβ1-dependent podocyte dysfunction
Current Opinion in Nephrology and Hypertension, 2013The glomerular filtration barrier is a unique structure characterized by a specialized framework of podocytes. Transforming growth factor-β1 (TGFβ1) upregulation occurs in virtually all chronic kidney diseases and is associated with podocyte injury and proteinuria. This review is aimed at describing the latest advances made in the understanding of TGFβ-
Michal, Herman-Edelstein +2 more
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Podocyte regeneration: who can become a podocyte?
The American journal of pathology, 2013This Commentary highlights the article by Pippin et al that showed that renin lineage cells may enhance glomerular regeneration by serving as progenitors for glomerular epithelial cells in glomerular disease characterized by podocyte depletion.
Florian, Grahammer +2 more
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Targeting podocyte-associated diseases☆
Advanced Drug Delivery Reviews, 2010Injury to the podocytes is the initiating cause of many renal diseases, leading to proteinuria with possible progression to end-stage renal disease. Podocytes are highly specialized cells, with an important role in maintaining the glomerular filtration barrier and producing growth factors for both mesangial cells and endothelial cells.
Leeuwis, J.W. +4 more
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Podocytes, glucose and insulin
Current Opinion in Nephrology and Hypertension, 2010In the last decade the importance of the podocyte in maintaining the integrity of the glomerular filtration barrier and prevention of albuminuria has become obvious. The leading cause of renal failure in the developed world is diabetic nephropathy. This has a defined natural history of progressive albuminuria.
Welsh, Gavin I, Coward, Richard J M
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Current Opinion in Nephrology and Hypertension, 2009
The podocyte is a key cell in the selective filtering action of the glomerular capillary wall. Podocyte injury is of pathogenetic and prognostic significance in human glomerular disease; podocyte repair and regeneration are important therapeutic targets.
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The podocyte is a key cell in the selective filtering action of the glomerular capillary wall. Podocyte injury is of pathogenetic and prognostic significance in human glomerular disease; podocyte repair and regeneration are important therapeutic targets.
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Experimental Cell Research, 2012
In an attempt to understand the basis of glomerular disease, significant progress has been made in understanding the mechanisms that determine podocyte development and the maintenance of podocyte health. This review examines recent advances in this area focusing on the podocyte intercellular junction, actin cytoskeletal dynamics, and determinants of ...
Puneet, Garg, Lawrence B, Holzman
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In an attempt to understand the basis of glomerular disease, significant progress has been made in understanding the mechanisms that determine podocyte development and the maintenance of podocyte health. This review examines recent advances in this area focusing on the podocyte intercellular junction, actin cytoskeletal dynamics, and determinants of ...
Puneet, Garg, Lawrence B, Holzman
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From placenta to podocyte: vascular and podocyte pathophysiology in preeclampsia
Clinical Nephrology, 2012Preeclampsia is a disorder of hypertension and proteinuria that affects 6 - 8% of normal pregnancies. Recent research has revealed many molecular mechanisms that may contribute to systemic endothelial dysfunction, glomerular capillary endotheliosis, dysregulation of the glomerular filtration apparatus, and podocyte loss. An ischemic placenta elaborates
Steven J, Wagner +3 more
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