Results 81 to 90 of about 13,097 (241)

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source

The structure of CLEC-2: mechanisms of dimerization and higher-order clustering

Platelets, 2021
The platelet C-type lectin-like receptor CLEC-2 drives inflammation-driven venous thrombosis in mouse models of thrombo-inflammatory disease with a minimal effect on hemostasis identifying it as a target for a new class of antiplatelet agent.
Eleyna M Martin, Malou Zuidscherwoude, Luis a Morán, Ying Di, Angel García, Steve P Watson   +5 more
doaj   +1 more source

Monocyte upregulation of podoplanin during early sepsis induces complement inhibitor release to protect liver function.

JCI Insight, 2020
Multiple organ failure in sepsis is a progressive failure of several interdependent organ systems. Liver dysfunction occurs early during sepsis and is directly associated with patient death; however, the underlying mechanism of liver dysfunction is ...
Zhanli Xie, Bojing Shao, Christopher M Hoover, M. McDaniel, Jian-hua Song, M. Jiang, Zhen-ni Ma, Fei Yang, Jingjing Han, X. Bai, C. Ruan, Lijun Xia   +11 more
semanticscholar   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Association of the co-expression of SOX2 and Podoplanin in the progression of oral squamous cell carcinomas - an immunohistochemical study

Journal of Applied Oral Science
SOX2 is a transcription factor related to the maintenance of stem cells in a pluripotent state. Podoplanin is a type of transmembrane sialoglycoprotein, which plays an important role in tumor progression and metastasis.
Sonali Pradhan, Vasudeva Guddattu, Monica Charlotte Solomon   +2 more
doaj   +1 more source

Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: A novel mechanism of haemostasis

Platelets, 2018
The podoplanin-CLEC-2 axis is critical in mice for prevention of hemorrhage in the cerebral vasculature during mid-gestation. This raises the question as to how platelets are captured by podoplanin on neuroepithelial cells in a high shear environment. In
Stephanie E. Lombard, Alice Y. Pollitt, Craig E. Hughes, Ying Di, Tom Mckinnon, Chris A. O’callaghan, Steve P. Watson   +6 more
doaj   +1 more source

Role of podoplanin expression in deciding the invasive potential of ameloblastoma – A retrospective IHC study

Journal of Oral Biology and Craniofacial Research, 2016
Background: The aim of this study was to investigate the podoplanin expression in epithelial odontogenic tumors both non-aggressive and aggressive, tumors with and without ectomesenchyme and remnants of the odontogenic epithelium from dental follicles ...
Sindhu M. Ganvir, Pratima G. Khobragade, Swati A. Bamane, Ramnivas Kumavat, Amit Dalmia   +4 more
doaj   +1 more source

Detection of Circulating Tumor Cells (CTCs) in Malignant Pleural Mesothelioma (MPM) with the “Universal” CTC-Chip and An Anti-Podoplanin Antibody NZ-1.2

Cells, 2020
Circulating tumor cell (CTC) is a potentially useful surrogate of micro-metastasis, but detection of rare tumor cells contaminated in a vast majority of normal hematologic cells remains technical challenges. To achieve effective detection of a variety of
T. Kuwata, K. Yoneda, Masataka Mori, Masatoshi Kanayama, K. Kuroda, Mika K. Kaneko, Y. Kato, F. Tanaka   +7 more
semanticscholar   +1 more source

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley   +1 more source

Development of Core-Fucose-Deficient Humanized and Chimeric Anti-Human Podoplanin Antibodies

Monoclonal antibodies in immunodiagnosis and immunotherapy, 2020
Podoplanin (PDPN), a 36-kDa type I transmembrane O-glycoprotein, is expressed in normal cells, including renal epithelial cells (podocytes), lymphatic endothelial cells, and pulmonary type I alveolar cells, and in cancer cells, including brain tumors and
M. Kaneko, T. Ohishi, Takuro Nakamura, H. Inoue, Junko Takei, M. Sano, Teizo Asano, Yusuke Sayama, Hideki Hosono, Hiroyoshi Suzuki, M. Kawada, Y. Kato   +11 more
semanticscholar   +1 more source