Results 51 to 60 of about 836,803 (300)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Micro-Injection Moulding Of Three-Dimensional Integrated Microfluidic Devices [PDF]

, 2009
This thesis investigates the use of micro-injection moulding (μIM), as a high-volume process, for producing three-dimensional, integrated microfluidic devices.
Attia, Usama M.
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Effect of liquid level monitor gas injection point size on information source amplitude-frequency characteristics

Scientific Reports
In order to analyse the effect of the injection point size of the CBM (Coalbed Methane) well level monitor on the amplitude and frequency of pressure pulsations in the wellhead manifold, numerical simulations and experiments were carried out to ...
Pu Liu, Kailun Quan, Kaixuan Li, Xinyuan Wu, Zhongzhi Hu   +4 more
doaj   +1 more source

The Effect of Intradermal Injection with Two Different Injection Techniques on Pain and Functional Status in Patients with Chronic Nonspecific Neck Pain

Medeniyet Medical Journal
Objective: This study aimed to compare the effectiveness of different mesotherapy techniques applied at various dermal depths on pain, functional status, and quality of life in patients with non-specific neck pain.
Sadiye MURAT
doaj   +1 more source

Injection scheme with deflecting cavity for a fourth-generation storage ring

Physical Review Accelerators and Beams, 2019
We suggest a new on-axis injection scheme that uses a transverse deflecting rf cavity to kick the incoming beam into an already populated bucket but with a timing offset from the synchronous phase.
J. Kim, G. Jang, M. Yoon, B-H. Oh, J. Lee, J. Ko, Y. Parc, T. Ha, D. Kim, S. Kim, S. Shin   +10 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Rheological investigation of manufacturability and injectability of highly concentrated monoclonal antibody formulations [PDF]

, 2014
Highly concentrated protein therapeutics offer a convenient way for subcutaneous (sc) drug administration by the patient him-/herself or a healthcare professional. As the therapy e.g.
Allmendinger, Andrea Martina
core   +1 more source

Adaptive process control of the changeover point for injection molding process

Journal of Low Frequency Noise, Vibration and Active Control, 2021
To increase the productivity of injection molding machines, we developed a smart injection part weight stability control system based on C++ programming and domain knowledge.
Yi-Sheng Chen, Kuo-Tsai Wu, Ming-Hong Tsai, Sheng-Jye Hwang, Huei-Huang Lee, Hsin-Shu Peng, Hsiao-Yeh Chu   +6 more
doaj   +1 more source