Results 71 to 80 of about 836,803 (300)

Numerical Investigation of the Influence of Injection Scheme on the Ethylene Supersonic Combustion

Advances in Mechanical Engineering, 2014
Ethylene supersonic combustion flow field in different injection schemes was studied numerically in the flight Mach 4. The results show that injection pressure has significant influence on the location of the separation zone and the heat release region ...
Hao Ouyang, Weidong Liu, Mingbo Sun
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Performance Comparison of the Vapor-Injection Cycle in Terms of Branching Points of the Injection Stream

, 2012
The performance of the two types of vapor-injection (VI) cycles in a heat pump system is compared. The vapor-injection cycle using an internal heat exchanger (IHX) has a choice to select the branching point of the injection stream.
Kim, Min Soo, Roh, Chul Woo
core  

Targeted Collection of Plasmid DNA in Large and Growing Animal Muscles 6 Weeks after DNA Vaccination with and without Electroporation

Journal of Immunology Research, 2015
DNA vaccination has been developed in the last two decades in human and animal species as a promising alternative to conventional vaccination. It consists in the injection, in the muscle, for example, of plasmid DNA encoding the vaccinating polypeptide ...
Daniel Dory, Vincent Le Moigne, Roland Cariolet, Véronique Béven, André Keranflec’h, André Jestin   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Nitrogen point injection in ridge-till corn

, 1989
Ridge conservation tillage systems are receiving increased attention as an alternative to flat no-till systems for row crop production. A recently-developed fertilizer applicator, the spoke-wheel injector has potential to improve fertilizer-use ...
Blaylock, Alan
core   +1 more source

Weakly pointed trees and partial injections

Journal of Symbolic Logic, 2008
AbstractWe define the notion of a weakly pointed tree, and characterize the amount of genericity necessary to prevent a uniformly branching tree being weakly pointed. We use these ideas to show there is no topological analogue of a measure-theoretic selection theorem of Graf and Mauldin.
openaire   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Characterizing the vertical variations of hydraulic conductivity of an unconsolidated aquifer based on the direct-push point-source injection tests

Shuiwen dizhi gongcheng dizhi
Hydraulic conductivity (K) and its spatial variability are critical factors governing groundwater flow and solute transport processes. Traditional methods, such as pumping tests and slug tests, often treat the aquifers as homogeneous to derive equivalent
Zhanfeng ZHAO, Xianfang SONG
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source