Results 1 to 10 of about 665,827 (257)

Sequence analysis of bla _CTX-M-28 , an ESBL responsible for third-generation cephalosporin resistance in Enterobacteriaceae, for the first time in India

Indian Journal of Pathology and Microbiology, 2008
The most common group of ESBLs not belonging to the bla TEM or bla SHV families were termed bla CTX-M , to highlight their ESBLs′ greater activity against cefotaxime than against ceftazidime.
Kingsley Jemima, Verghese Susan
doaj  

CEBPA point mutations in hematological malignancies [PDF]

Leukemia, 2005
The CCAAT/enhancer-binding protein-alpha (CEBPA) is a transcription factor strongly implicated in myelopoiesis through control of proliferation and differentiation of myeloid progenitors. Recently, several works have reported the presence of CEBPA-acquired mutations in hematological malignancies.
H, Leroy, C, Roumier, P, Huyghe, V, Biggio, P, Fenaux, C, Preudhomme   +5 more
openaire   +2 more sources

Point Mutation of Hoxd12 in Mice

Yonsei Medical Journal, 2008
Genes of the HoxD cluster play a major role in vertebrate limb development, and changes that modify the Hoxd12 locus affect other genes also, suggesting that HoxD function is coordinated by a control mechanism involving multiple genes during limb morphogenesis. In this study, mutant phenotypes were produced by treatment of mice with a chemical mutagen,
Cho, JW, Cho, KW, Kim, JY, Jung, HS, Song, CW, Cho, KH   +5 more
openaire   +4 more sources

SHOX point mutations in dyschondrosteosis [PDF]

Journal of Medical Genetics, 2001
Dyschondrosteosis (DCS) has been recently ascribed to mutations of the SHOX gene on the pseudoautosomal region of the X and Y chromosomes.1 2 Most cases are accounted for by large scale deletions3-7 and only two point mutations have been hitherto identified in exon 4 (R195 X and Y199X1 2).
C, Huber, V, Cusin, M, Le Merrer, M, Mathieu, V, Sulmont, N, Dagoneau, A, Munnich, V, Cormier-Daire   +7 more
openaire   +2 more sources

Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia

Disease Models & Mechanisms, 2020
Friedreich's ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by reduced expression of the mitochondrial protein frataxin (FXN).
Daniel Fil, Balu K. Chacko, Robbie Conley, Xiaosen Ouyang, Jianhua Zhang, Victor M. Darley-Usmar, Aamir R. Zuberi, Cathleen M. Lutz, Marek Napierala, Jill S. Napierala   +9 more
doaj   +1 more source

Allelic variation of the AvrSr50 effector increased virulence of the Puccinia graminis f. sp. tritici on Sr50-carrying wheat lines [PDF]

Journal of Advances in Plant Protection
Wheat stem rust, caused by the biotrophic pathogen Puccinia graminis f. sp. tritici (Pgt), is an important disease worldwide. To overcome host immunity, Pgt secretes several effectors, including AvrSr35 and AvrSr50.
Mansoor Karimi-Jashni, Fatemeh khanbooluki, Mahmoud Nasrollahi   +2 more
doaj   +1 more source

Mutation in Rh48: Assessment for possible mutation prone point [PDF]

Indian Journal of Hematology and Blood Transfusion, 2010
Rh antigen is a widely studied but not already known antigen. RH48 (JAL) is a low-incidence Rh antigen of unknown molecular background and is proposed for association with weakened expression of RhCE antigens. Here, the author performed a bioinformatics approach to study the probability of JAL mutation.
openaire   +2 more sources

Development of a Novel Loop-Mediated Isothermal Amplification Method to Detect Guiana Extended-Spectrum (GES) β-Lactamase Genes in Pseudomonas aeruginosa

Frontiers in Microbiology, 2019
Infections caused by multidrug-resistant Pseudomonas aeruginosa in hospitalized patients are often fatal, and nosocomial infections caused by Guiana extended-spectrum (GES) β-lactamase-producing strains are of growing concern.
Chika Takano, Mitsuko Seki, Mitsuko Seki, Dong Wook Kim, Dong Wook Kim, Humphrey Gardner, Robert E. McLaughlin, Paul E. Kilgore, Kazunari Kumasaka, Satoshi Hayakawa   +9 more
doaj   +1 more source

Push It to the Limit: Identification of Novel Amino Acid Changes on the Acetolactate Synthase Enzyme of Rice That Putatively Confer High Level of Tolerance to Different Imidazolinones

Frontiers in Bioengineering and Biotechnology, 2020
Advancements in genetically modified herbicide tolerance technology opened a new way to manage weed populations in crop fields. Since then, many important genetically modified crops that are tolerant to various herbicides have been developed and ...
Giseli Buffon, Thainá Inês Lamb, Mara Cristina Barbosa Lopes, Raul Antonio Sperotto, Raul Antonio Sperotto, Luís Fernando Saraiva Macedo Timmers, Luís Fernando Saraiva Macedo Timmers   +6 more
doaj   +1 more source

Decoding germline de novo point mutations [PDF]

Nature Genetics, 2016
Analysis of a large whole-genome sequencing data set of 36,441 high-quality de novo mutations (DNMs) that arose in 816 family trios provides an unprecedented view into the landscape of DNMs in the germ line. This work both refines and challenges some of the views previously held on the nature and origin of DNMs.
openaire   +2 more sources