Results 21 to 30 of about 5,667,138 (292)

DNA-based biosensor platforms for the detection of TP53 mutation [PDF]

, 2012
A DNA-based assay for the detection of one-point mutation in TP53 gene, responsible for lung cancer, was developed using a surface plasmon resonance (SPR) and a quartz crystal microbalance (QCM) biosensor systems.
Altintas, Zeynep, Altıntaş, Zeynep, Tothill, I. E., Tothill, Ibtisam E.   +3 more
core   +1 more source

Variability of Iron Load in Patients of Sickle Cell Anaemia (HbSS): A study from Eastern India [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Sickle Cell Anaemia (SCA) is one of the commonest haemoglobinopathies due to a point mutation (A→T) of the b-globin gene. Out of five haplotypes, the Arab-Indian haplotype present in India is one of the least severe phenotype and least ...
Pranati Mohanty, Rabindra Kumar Jena, Sudha Sethy   +2 more
doaj   +1 more source

RIPCAL: a tool for alignment-based analysis of repeat-induced point mutations in fungal genomic sequences [PDF]

, 2008
Background Repeat-induced point mutation (RIP) is a fungal-specific genome defence mechanism that alters the sequences of repetitive DNA, thereby inactivating coding genes.
Hane, J., Oliver, Richard, James K Hane, Richard P Oliver, Oliver, R.P., Hane James K, Hane, J.K., Oliver Richard P   +7 more
core   +1 more source

Study of SNP 775C>T polymorphism within the bovine ITGB2 gene in Polish Black-and-White cattle and in local breeds of cattle

Czech Journal of Animal Science, 2007
The present study addresses the characteristics of the frequency and segregation of alleles determining the SNP 775C>T polymorphism within the bovine ITGB2 gene in the Black-and-White cattle population as well as in two endemic breeds of Polish Red ...
U. Czarnik, M. Galiński, T. Zabolewicz, Ch.S. Pareek   +3 more
doaj   +1 more source

Implementation of two high through-put techniques in a novel application: detecting point mutations in large EMS mutated plant populations [PDF]

, 2009
Background - The establishment of mutant populations together with the strategies for targeted mutation detection has been applied successfully to a large number of organisms including many species in the plant kingdom.
Hermans, F.W.K., Bachem, C.W.B., Eibertus N van Loo, van Loo, E.N., Marion HBJ Van de Wal, Freddy WK Hermans, Richard GF Visser, Loo, E.N., van, Visser, R.G.F., Antoine LF Gady, Christian WB Bachem, Gady, A.L.F., Wal, M.H.B.J., van de, van de Wal, M.H.B.J.   +13 more
core   +1 more source

A Genomic Point Mutation in the Extracellular Domain of the Thyrotropin Receptor in Patients with Graves’ Ophthalmopathy [PDF]

, 1994
Orbital and pretibial fibroblasts are targets of autoimmune attack in Graves' ophthalmopathy (GO) and pretibial dermopathy (PTD). The fibroblast autoantigen involved in these peripheral manifestations of Graves' disease and the reason for the association
Sarkar, Gobinda, Bahn, Rebecca S., Heufelder, Armin E., Dutton, Charyl M., R. S. Bahn   +4 more
core   +1 more source

Semantically Driven Mutation in Genetic Programming [PDF]

, 2008
Using semantic analysis, we present a technique known as semantically driven mutation which can explicitly detect and apply behavioural changes caused by the syntactic changes in programs that result from the mutation operation. Using semantically driven
Beadle, Lawrence, Colin G. Johnson, Johnson, Colin G., Lawrence Beadle   +3 more
core   +1 more source

KRAS G12D Mutation Subtype in Pancreatic Ductal Adenocarcinoma: Does It Influence Prognosis or Stage of Disease at Presentation?

Cells, 2022
Background: KRAS G12D mutation subtype is present in over 40% of pancreatic ductal adenocarcinoma (PDAC), one of the leading global causes of cancer death.
Henry Shen, Joanne Lundy, Andrew H. Strickland, Marion Harris, Michael Swan, Christopher Desmond, Brendan J. Jenkins, Daniel Croagh   +7 more
doaj   +1 more source

Detection of A2143G, A2142C, and A2142G Point Mutations with Real-Time PCR in Stool Specimens from Children Infected with Helicobacter pylori

Diagnostics, 2022
Reports have indicated an increasing prevalence of clarithromycin resistance in children relative to adults. Thus, it is important to investigate primary clarithromycin resistance before therapy to avoid treatment failure.
Nesrin Gareayaghi, Bekir Kocazeybek
doaj   +1 more source

Point Mutation Rate of Bacteriophage ΦX174 [PDF]

Genetics, 2009
Abstract The point mutation rate of phage ΦX174 was determined using the fluctuation test. After identifying the genetic changes associated with the selected phenotype, we obtained an estimate of 1.0 × 10−6 substitutions per base per round of copying, which is consistent with Drake's rule (0.003 mutations per genome per round of copying ...
Cuevas, José M., Duffy, Siobain, Sanjuán, Rafael   +2 more
openaire   +3 more sources