Results 11 to 20 of about 5,667,138 (292)

Pyruvic Acid Production from Sucrose by Escherichia coli Pyruvate Dehydrogenase Variants

Fermentation, 2023
Sucrose is an abundant, cheap, and renewable carbohydrate which makes it an attractive feedstock for the biotechnological production of chemicals. Escherichia coli W, one of the few safe E.
W. Chris Moxley, Mark A. Eiteman
doaj   +1 more source

Pigs with an INS point mutation derived from zygotes electroporated with CRISPR/Cas9 and ssODN

Frontiers in Cell and Developmental Biology, 2023
Just one amino acid at the carboxy-terminus of the B chain distinguishes human insulin from porcine insulin. By introducing a precise point mutation into the porcine insulin (INS) gene, we were able to generate genetically modified pigs that secreted ...
Fuminori Tanihara, Maki Hirata, Maki Hirata, Zhao Namula, Zhao Namula, Lanh Thi Kim Do, Lanh Thi Kim Do, Naoaki Yoshimura, Naoaki Yoshimura, Qingyi Lin, Qingyi Lin, Koki Takebayashi, Koki Takebayashi, Tetsushi Sakuma, Takashi Yamamoto, Takeshige Otoi, Takeshige Otoi   +16 more
doaj   +1 more source

Surface charge changes in spike RBD mutations of SARS-CoV-2 and its variant strains alter the virus evasiveness via HSPGs: A review and mechanistic hypothesis

Frontiers in Public Health, 2022
With the COVID-19 pandemic continuing, more contagious SARS-CoV-2 variants, including Omicron, have been emerging. The mutations, especially those that occurred on the spike (S) protein receptor-binding domain (RBD), are of significant concern due to ...
Zhongyun Zhang, Zhongyun Zhang, Juan Zhang, Juan Zhang, Jiqiu Wang, Jiqiu Wang   +5 more
doaj   +1 more source

A cell function study on calcium regulation of a novel calcium-sensing receptor mutation (p.Tyr825Phe) [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2021
Purpose Autosomal dominant hypocalcemia with hypercalciuria is a genetic disease characterized by hypoparathyroidism with hypercalciuria. We discovered a novel variant (p.Tyr825Phe[Y825F]) of the CASR gene in a neonate with congenital hypoparathyroidism ...
Jung Eun Moon, Hee-Young Yang, Gabbine Wee, Suk-Hyun ParK, Cheol Woo Ko   +4 more
doaj   +1 more source

Effectiveness of 7-day triple therapy with half-dose clarithromycin for the eradication of Helicobacter pylori without the A2143G and A2142G point mutations of the 23S rRNA gene in a high clarithromycin resistance area

Frontiers in Medicine, 2023
BackgroundTailored therapy has been widely used for patients with Helicobacter pylori (H. pylori) infection in South Korea. Herein, we evaluated the treatment outcomes of tailored clarithromycin-based triple therapy (TT) in patients infected with H ...
Seong Hyun Cho, Moon Sik Park, Seon-Young Park, Dong Hyun Kim, Hye-Su You, Hyun-Soo Kim   +5 more
doaj   +1 more source

In silico reversal of repeat-induced point mutation (RIP) identifies the origins of repeat families and uncovers obscured duplicated genes [PDF]

, 2010
Background: Repeat-induced point mutation (RIP) is a fungal genome defence mechanism guarding against transposon invasion. RIP mutates the sequence of repeated DNA and over time renders the affected regions unrecognisable by similarity search tools such ...
Hane, J., Oliver, Richard, James K Hane, Richard P Oliver, Oliver, R.P., Hane James K, Hane, J.K., Oliver Richard P   +7 more
core   +1 more source

The F238L Point Mutation in the Cannabinoid Type 1 Receptor Enhances Basal Endocytosis via Lipid Rafts

Frontiers in Molecular Neuroscience, 2018
Defining functional domains and amino acid residues in G protein coupled receptors (GPCRs) represent an important way to improve rational drug design for this major class of drug targets.
Melanie Wickert, Keri L. Hildick, Gemma L. Baillie, Ruth Jelinek, Alejandro Aparisi Rey, Krisztina Monory, Miriam Schneider, Miriam Schneider, Ruth A. Ross, Jeremy M. Henley, Beat Lutz, Beat Lutz   +11 more
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Point Mutation of Hoxd12 in Mice

Yonsei Medical Journal, 2008
Genes of the HoxD cluster play a major role in vertebrate limb development, and changes that modify the Hoxd12 locus affect other genes also, suggesting that HoxD function is coordinated by a control mechanism involving multiple genes during limb morphogenesis. In this study, mutant phenotypes were produced by treatment of mice with a chemical mutagen,
Cho, JW, Cho, KW, Kim, JY, Jung, HS, Song, CW, Cho, KH   +5 more
openaire   +4 more sources

Mutation testing on an object-oriented framework: An experience report [PDF]

, 2011
This is the preprint version of the article - Copyright @ 2011 ElsevierContext The increasing presence of Object-Oriented (OO) programs in industrial systems is progressively drawing the attention of mutation researchers toward this paradigm.
Sergio Segura, Segura, S, Benavides, D, Antonio Ruiz-Cortés, Ruiz Cortés, Antonio, Segura Rueda, Sergio, Robert M. Hierons, Benavides Cuevas, David Felipe, Hierons, Robert M., David Benavides, Hierons, RM, Ruiz-Cortes, A   +11 more
core   +1 more source

Resistance risk and molecular mechanism associated with resistance to picoxystrobin in Colletotrichum truncatum and Colletotrichum gloeosporioides

Journal of Integrative Agriculture, 2023
Anthracnose, caused by Colletotrichum truncatum and C. gloeosporioides, is amongst the most serious diseases of soybean in China. Picoxystrobin, a quinone outside inhibitor fungicide, is commonly used for the control of anthracnose.
Niu-niu SHI, Jin-pan LIAN, De-zhu QIU, Fu-ru CHEN, Yi-xin DU   +4 more
doaj   +1 more source