Results 11 to 20 of about 7,351,528 (349)

Tryptophan residue of plasmid-encoded Pgp3 is important for Chlamydia muridarum to induce hydrosalpinx in mice

Frontiers in Microbiology, 2023
The crucial role of plasmid-encoded protein Pgp3 in Chlamydia pathogenesis has been demonstrated in various animal models. Previous studies have revealed that the Pgp3-deficient C.
Yumeng Huang, Haoqing Wu, Yina Sun, Yuanjun Liu   +3 more
doaj   +1 more source

Pyruvic Acid Production from Sucrose by Escherichia coli Pyruvate Dehydrogenase Variants

Fermentation, 2023
Sucrose is an abundant, cheap, and renewable carbohydrate which makes it an attractive feedstock for the biotechnological production of chemicals. Escherichia coli W, one of the few safe E.
W. Chris Moxley, Mark A. Eiteman
doaj   +1 more source

Pigs with an INS point mutation derived from zygotes electroporated with CRISPR/Cas9 and ssODN

Frontiers in Cell and Developmental Biology, 2023
Just one amino acid at the carboxy-terminus of the B chain distinguishes human insulin from porcine insulin. By introducing a precise point mutation into the porcine insulin (INS) gene, we were able to generate genetically modified pigs that secreted ...
Fuminori Tanihara, Maki Hirata, Maki Hirata, Zhao Namula, Zhao Namula, Lanh Thi Kim Do, Lanh Thi Kim Do, Naoaki Yoshimura, Naoaki Yoshimura, Qingyi Lin, Qingyi Lin, Koki Takebayashi, Koki Takebayashi, Tetsushi Sakuma, Takashi Yamamoto, Takeshige Otoi, Takeshige Otoi   +16 more
doaj   +1 more source

Surface charge changes in spike RBD mutations of SARS-CoV-2 and its variant strains alter the virus evasiveness via HSPGs: A review and mechanistic hypothesis

Frontiers in Public Health, 2022
With the COVID-19 pandemic continuing, more contagious SARS-CoV-2 variants, including Omicron, have been emerging. The mutations, especially those that occurred on the spike (S) protein receptor-binding domain (RBD), are of significant concern due to ...
Zhongyun Zhang, Zhongyun Zhang, Juan Zhang, Juan Zhang, Jiqiu Wang, Jiqiu Wang   +5 more
doaj   +1 more source

Effectiveness of 7-day triple therapy with half-dose clarithromycin for the eradication of Helicobacter pylori without the A2143G and A2142G point mutations of the 23S rRNA gene in a high clarithromycin resistance area

Frontiers in Medicine, 2023
BackgroundTailored therapy has been widely used for patients with Helicobacter pylori (H. pylori) infection in South Korea. Herein, we evaluated the treatment outcomes of tailored clarithromycin-based triple therapy (TT) in patients infected with H ...
Seong Hyun Cho, Moon Sik Park, Seon-Young Park, Dong Hyun Kim, Hye-Su You, Hyun-Soo Kim   +5 more
doaj   +1 more source

[Point mutation].

Nihon rinsho. Japanese journal of clinical medicine, 2019
A point mutation is when a single base pair is altered. Point mutations can have one of three effects. First, the base substitution can be a silent mutation where the altered codon corresponds to the same amino acid.
Y. Yuasa
semanticscholar   +1 more source

Sotorasib for Lung Cancers with KRAS p.G12C Mutation.

New England Journal of Medicine, 2021
BACKGROUND Sotorasib showed anticancer activity in patients with KRAS p.G12C-mutated advanced solid tumors in a phase 1 study, and particularly promising anticancer activity was observed in a subgroup of patients with non-small-cell lung cancer (NSCLC).
F. Skoulidis, Bob T. Li, G. Dy, T. Price, G. Falchook, J. Wolf, A. Italiano, M. Schuler, H. Borghaei, F. Barlesi, T. Kato, A. Curioni-Fontecedro, A. Sacher, A. Spira, S. Ramalingam, Toshiaki Takahashi, B. Besse, A. Anderson, A. Ang, Q. Tran, O. Mather, H. Henary, G. Ngarmchamnanrith, G. Friberg, V. Velcheti, R. Govindan   +25 more
semanticscholar   +1 more source

The F238L Point Mutation in the Cannabinoid Type 1 Receptor Enhances Basal Endocytosis via Lipid Rafts

Frontiers in Molecular Neuroscience, 2018
Defining functional domains and amino acid residues in G protein coupled receptors (GPCRs) represent an important way to improve rational drug design for this major class of drug targets.
Melanie Wickert, Keri L. Hildick, Gemma L. Baillie, Ruth Jelinek, Alejandro Aparisi Rey, Krisztina Monory, Miriam Schneider, Miriam Schneider, Ruth A. Ross, Jeremy M. Henley, Beat Lutz, Beat Lutz   +11 more
doaj   +1 more source

A point mutation of integrin beta 1 subunit blocks binding of alpha 5 beta 1 to fibronectin and invasin but not recruitment to adhesion plaques. [PDF]

, 1992
A point mutation in a highly conserved region of the beta 1 subunit, Asp130 to Ala (D130A) substitution, abrogates the Arg-Gly-Asp (RGD)-dependent binding of alpha 5 beta 1 to fibronectin (FN) without disrupting gross structure or heterodimer assembly ...
Ginsberg, MH, Mandelman, D, Puzon, W, Takada, Y, Ylänne, J   +4 more
core   +2 more sources

OsCIPK7 point-mutation leads to conformation and kinase-activity change for sensing cold response.

Journal of Integrative Plant Biology, 2019
Calcineurin B-like interacting protein kinases (CIPKs) play important roles via environmental stress. However, less is known how to sense the stress in molecular structure conformation level.
Dajian Zhang, Xiaoyu Guo, Yunyuan Xu, Hao Li, Liang Ma, Xuefeng Yao, Y. Weng, Yan Guo, Chun-Ming Liu, K. Chong   +9 more
semanticscholar   +1 more source