Results 51 to 60 of about 1,259,904 (287)

Lack of RNA-DNA oligonucleotide (chimeraplast) mutagenic activity in mouse embryos [PDF]

, 2005
There are numerous reports of the use of RNA-DNA oligonucleoticles (chimeraplasts) to correct point mutations in vitro and in vivo, including the human apolipoprotein E gene (ApoE).
Owen, JS, Simons, JP, Tagalakis, AD
core   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Production of Esters in Escherichia coli Using Citrate Synthase Variants

Microorganisms
Acetate esters comprise a wide range of products including fragrances and industrial solvents. Biosynthesis of esters offers a promising alternative to chemical synthesis because such routes use renewable carbohydrate resources and minimize the ...
Jacoby C. Shipmon, Pasupathi Rathinasabapathi, Michael L. Broich, Hemansi, Mark A. Eiteman   +4 more
doaj   +1 more source

Evaluation of Fungicide Resistance of the Brown Shot-hole Pathogens of Cherry Trees in Korea [PDF]

The Plant Pathology Journal
Cherry trees (Prunus serrulata var. spontanea, Prunus × yedoensis), a widely cultivated ornamental street trees grown in Korea, are vulnerable to variety of diseases particularly the prevailing brown shot-hole disease, thus needs effective maintenance ...
Young Min Ko, Donggye Lee, Min Seong Seok, Donah Mary Macoy, Youn-Sig Kwak   +4 more
doaj   +1 more source

Mutations in the Second Alternative Oxidase Gene: A New Approach to Group Aspergillus niger Strains

Journal of Fungi, 2023
Alternative oxidase is a terminal oxidase in the branched mitochondrial electron transport chain of most fungi including Aspergillus niger (subgenus Circumdati, section Nigri). A second, paralogous aox gene (aoxB) is extant in some A.
Michel Flipphi, Alexandra Márton, Vivien Bíró, Norbert Ág, Erzsébet Sándor, Erzsébet Fekete, Levente Karaffa   +6 more
doaj   +1 more source

L925I mutation in the Para-type sodium channel is associated with pyrethroid resistance in Triatoma infestans from the Gran Chaco region [PDF]

, 2014
Background: Chagas' disease is an important public health concern in Latin America. Despite intensive vector control efforts using pyrethroid insecticides, the elimination of Triatoma infestans has failed in the Gran Chaco, an ecoregion that extends over
Capriotti, Natalia, Mougabure Cueto, Gastón Adolfo, Ons, Sheila, Rivera Pomar, Rolando   +3 more
core   +3 more sources

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

On Exceptional Times for generalized Fleming-Viot Processes with Mutations

, 2013
If $\mathbf Y$ is a standard Fleming-Viot process with constant mutation rate (in the infinitely many sites model) then it is well known that for each $t>0$ the measure $\mathbf Y_t$ is purely atomic with infinitely many atoms.
B Schmuland, DA Dawson, DA Dawson, Donnelly, EB Dynkin, J Berestycki, J Bertoin, J Bertoin, J Bertoin, J Jacod, J Lamperti, J Pitman, J Pitman, LA Shepp, M Birkner, M Birkner, M Birkner, N Berestyck, N Ikeda, N Konno, P Donnelly, SN Ethier, SN Ethier, T Duquesne, TG Kurtz, WH Fleming, Z Fu, Z Li, Z Li   +28 more
core   +2 more sources

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source