Results 61 to 70 of about 5,843,460 (297)

Proteins’ Evolution upon Point Mutations

ACS Omega, 2022
The primary aim of this work is to explore how proteins point mutations impact their marginal stability and, hence, their evolvability. With this purpose, we show that the use of four classic notions, namely, those from Leibniz & Kant (1768), Maynard Smith (1970), Einstein & Infeld (1961), and Anfinsen (1973), is sufficient for a better ...
openaire   +3 more sources

A histone point mutation that switches on autophagy [PDF]

Autophagy, 2014
The multifaceted process of aging inevitably leads to disturbances in cellular metabolism and protein homeostasis. To meet this challenge, cells make use of autophagy, which is probably one of the most important pathways preserving cellular protection under stressful conditions.
Eisenberg, Tobias, Schroeder, Sabrina, Büttner, Sabrina, Carmona-Gutierrez, Didac, Pendl, Tobias, Andryushkova, Aleksandra, Mariño, Guillermo, Pietrocola, Federico, Harger, Alexandra, Zimmermann, Andreas, Magnes, Christoph, Sinner, Frank, Sedej, Simon, Pieber, Thomas R., Dengjel, Jörn, Sigrist, Stephan J., Kroemer, Guido, Madeo, Frank F.   +17 more
openaire   +3 more sources

The role of the A C395 IFNGR1 mutation in determining susceptibility to intracellular infection in Malta [PDF]

, 2012
Background: The first human mycobacterial susceptibility gene was identified amongst four children on the island of Malta in 1995. All affected children were homozygous for a nonsense mutation at position 395 of the interferon gamma receptor 1 (IFNGR1 ...
Levin, Mike, Attard Montalto, Simon, Mangion, Mariella, Hibberd, Martin, Felice, Alex, Anderson, Suzanne T., Newport, Melanie J.   +6 more
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Sequence analysis of bla _CTX-M-28 , an ESBL responsible for third-generation cephalosporin resistance in Enterobacteriaceae, for the first time in India

Indian Journal of Pathology and Microbiology, 2008
The most common group of ESBLs not belonging to the bla TEM or bla SHV families were termed bla CTX-M , to highlight their ESBLs′ greater activity against cefotaxime than against ceftazidime.
Kingsley Jemima, Verghese Susan
doaj  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Molecular dynamics approach to the I431V mutational impact on thyroid hormone receptor-beta

Bibechana, 2018
The point mutations like I431V on thyroid hormone receptor-beta (THR-β) gene cause resistance to thyroid hormones (RTH) with the clinical diagnosis of elevated free triiodothyronine (T3) and free thyroxin (T4) but not suppressed thyroid stimulating ...
Tika Ram Lamichhane, Sharma Paudel, Binod Kumar Yadav, Hari Prasad Lamichhane   +3 more
doaj   +3 more sources

Single channel study of the spasmodic mutation α1A52S in recombinant rat glycine receptors [PDF]

, 2007
Inherited defects in glycine receptors lead to hyperekplexia, or startle disease. A mutant mouse, spasmodic, that has a startle phenotype, has a point mutation (A52S) in the glycine receptor α1 subunit.
Colquhoun, D., Groot-Kormelink, P., Plested, A.J.R., Sivilotti, L.G.   +3 more
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

PICMI: mapping point mutations on genomes [PDF]

Bioinformatics, 2010
Abstract Motivation: Several international collaborations and local projects are producing extensive catalogues of genomic variations that are supplementing existing collections such as the OMIM catalogue. The flood of this type of data will keep increasing and, especially, it will be relevant to a wider user base, including not only ...
LE PERA, LOREDANA, MARCATILI, PAOLO, TRAMONTANO, ANNA   +2 more
openaire   +5 more sources