Results 61 to 70 of about 680,015 (260)

Mutation in Rh48: Assessment for possible mutation prone point [PDF]

Indian Journal of Hematology and Blood Transfusion, 2010
Rh antigen is a widely studied but not already known antigen. RH48 (JAL) is a low-incidence Rh antigen of unknown molecular background and is proposed for association with weakened expression of RhCE antigens. Here, the author performed a bioinformatics approach to study the probability of JAL mutation.
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Allelic variation of the AvrSr50 effector increased virulence of the Puccinia graminis f. sp. tritici on Sr50-carrying wheat lines [PDF]

Journal of Advances in Plant Protection
Wheat stem rust, caused by the biotrophic pathogen Puccinia graminis f. sp. tritici (Pgt), is an important disease worldwide. To overcome host immunity, Pgt secretes several effectors, including AvrSr35 and AvrSr50.
Mansoor Karimi-Jashni, Fatemeh khanbooluki, Mahmoud Nasrollahi   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Production of Mevalonate from Glycerol by Escherichia coli Citrate Synthase Variants

Fermentation
Mevalonate is a biochemical precursor to a wide range of isoprenoids. Because the mevalonate pathway uses three moles of acetyl–CoA, native pathways which metabolize acetyl–CoA, including citrate synthase, strongly compete with mevalonate synthesis.
Caroline E. Hartner, Mark A. Eiteman
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Development of a Novel Loop-Mediated Isothermal Amplification Method to Detect Guiana Extended-Spectrum (GES) β-Lactamase Genes in Pseudomonas aeruginosa

Frontiers in Microbiology, 2019
Infections caused by multidrug-resistant Pseudomonas aeruginosa in hospitalized patients are often fatal, and nosocomial infections caused by Guiana extended-spectrum (GES) β-lactamase-producing strains are of growing concern.
Chika Takano, Mitsuko Seki, Mitsuko Seki, Dong Wook Kim, Dong Wook Kim, Humphrey Gardner, Robert E. McLaughlin, Paul E. Kilgore, Kazunari Kumasaka, Satoshi Hayakawa   +9 more
doaj   +1 more source

Push It to the Limit: Identification of Novel Amino Acid Changes on the Acetolactate Synthase Enzyme of Rice That Putatively Confer High Level of Tolerance to Different Imidazolinones

Frontiers in Bioengineering and Biotechnology, 2020
Advancements in genetically modified herbicide tolerance technology opened a new way to manage weed populations in crop fields. Since then, many important genetically modified crops that are tolerant to various herbicides have been developed and ...
Giseli Buffon, Thainá Inês Lamb, Mara Cristina Barbosa Lopes, Raul Antonio Sperotto, Raul Antonio Sperotto, Luís Fernando Saraiva Macedo Timmers, Luís Fernando Saraiva Macedo Timmers   +6 more
doaj   +1 more source