Results 71 to 80 of about 1,268,660 (340)

Mutation-Selection Balance: Ancestry, Load, and Maximum Principle

, 2002
We show how concepts from statistical physics, such as order parameter, thermodynamic limit, and quantum phase transition, translate into biological concepts in mutation-selection models for sequence evolution and can be used there.
Baake, Baake, Baake, Barton, Boerlijst, Bonhoeffer, Bürger, Bürger, Bürger, Bürger, Charlesworth, Crow, Crow, Demetrius, Demetrius, Eigen, Eigen, Eigen, Ellen Baake, Ethier, Ewens, Franz, Gabriel, Gabriel, Gillespie, Haldane, Hermisson, Higgs, Hofbauer, Hofbauer, Holger Wagner, Huynen, Jagers, Joachim Hermisson, Karlin, Karlin, Kauffman, Kauffman, Kesten, Kimura, Kimura, Kondrashov, Kondrashov, Leuthäusser, Leuthäusser, Maynard Smith, Moran, Nowak, O'Brien, Ohta, Ohta, Oliver Redner, Otto, Phillips, Sniegowski, Swetina, Swofford, Tarazona, Taylor, Wagner, Wagner, Wagner, Waxman, Wiehe, Wilkinson   +64 more
core   +1 more source

Mutations of the BRAF gene in human cancer [PDF]

, 2002
Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide screen for these genes, we have prioritized for analysis ...
Bignell, G.R., Bigner, D.D., Bottomley, W., Chenevix-Trench, G., Clegg, S., Cooper, C., Cossu, A., Cox, C., Darrow, T.L., Davies, H., Davis, N., Dicks, E., Edkins, S., Ewing, R., Flanagan, A., Floyd, Y., Futreal, P.A., Garnett, M.J., Gray, K., Gusterson, B.A., Hall, S., Hargrave, D., Hawes, R., Ho, J.W.C., Hooper, S., Hughes, J., Jayatilake, H., Kosmidou, V., Leung, S.Y., Maitland, N., Marais, R., Marshall, C.J., Menzies, A., Mould, C., Nicholson, A., Palmieri, G., Parker, A., Paterson, H., Pritchard-Jones, K., Riggins, G.J., Seigler, H.F., Shipley, J., Stephens, P., Stevens, C., Stratton, M.R., Teague, J., Watt, S., Weber, B.L., Wilson, R., Woffendin, H., Wooster, R., Yuen, S.T.   +51 more
core   +1 more source

CEBPA point mutations in hematological malignancies [PDF]

Leukemia, 2005
The CCAAT/enhancer-binding protein-alpha (CEBPA) is a transcription factor strongly implicated in myelopoiesis through control of proliferation and differentiation of myeloid progenitors. Recently, several works have reported the presence of CEBPA-acquired mutations in hematological malignancies.
H, Leroy, C, Roumier, P, Huyghe, V, Biggio, P, Fenaux, C, Preudhomme   +5 more
openaire   +2 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

The Effect of Mutators on Adaptability in Time-Varying Fitness Landscapes

, 2008
This Letter studies the quasispecies dynamics of a population capable of genetic repair evolving on a time-dependent fitness landscape. We develop a model that considers an asexual population of single-stranded, conservatively replicating genomes, whose ...
D. Voet, Emmanuel Tannenbaum, P. R. Painter, Pavel Gorodetsky   +3 more
core   +1 more source

Point Mutation of Hoxd12 in Mice

Yonsei Medical Journal, 2008
Genes of the HoxD cluster play a major role in vertebrate limb development, and changes that modify the Hoxd12 locus affect other genes also, suggesting that HoxD function is coordinated by a control mechanism involving multiple genes during limb morphogenesis. In this study, mutant phenotypes were produced by treatment of mice with a chemical mutagen,
Cho, JW, Cho, KW, Kim, JY, Jung, HS, Song, CW, Cho, KH   +5 more
openaire   +4 more sources

SHOX point mutations in dyschondrosteosis [PDF]

Journal of Medical Genetics, 2001
Dyschondrosteosis (DCS) has been recently ascribed to mutations of the SHOX gene on the pseudoautosomal region of the X and Y chromosomes.1 2 Most cases are accounted for by large scale deletions3-7 and only two point mutations have been hitherto identified in exon 4 (R195 X and Y199X1 2).
C, Huber, V, Cusin, M, Le Merrer, M, Mathieu, V, Sulmont, N, Dagoneau, A, Munnich, V, Cormier-Daire   +7 more
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Estimating the relative rate of recombination to mutation in bacteria from single-locus variants using composite likelihood methods [PDF]

, 2015
A number of studies have suggested using comparisons between DNA sequences of closely related bacterial isolates to estimate the relative rate of recombination to mutation for that bacterial species.
Biggs, Patrick, Fearnhead, Paul, French, Nigel, Holland, Barbara, Yu, Shoukai   +4 more
core   +4 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source