Results 1 to 10 of about 1,854 (151)
Inhibition of pokeweed antiviral protein (PAP) by turnip mosaic virus genome-linked protein (VPg). [PDF]
J Biol Chem, 2012 Pokeweed antiviral protein (PAP) from Phytolacca americana is a ribosome-inactivating protein (RIP) and an RNA N-glycosidase that removes specific purine residues from the sarcin/ricin loop of large rRNA, arresting protein synthesis at the translocation ...
Domashevskiy AV, Miyoshi H, Goss DJ.
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Pokeweed antiviral protein, a ribosome inactivating protein: activity, inhibition and prospects. [PDF]
Toxins (Basel), 2015 Viruses employ an array of elaborate strategies to overcome plant defense mechanisms and must adapt to the requirements of the host translational systems. Pokeweed antiviral protein (PAP) from Phytolacca americana is a ribosome inactivating protein (RIP) and is an RNA N-glycosidase that removes specific purine residues from the sarcin/ricin (S/R) loop ...
Domashevskiy AV, Goss DJ.
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De novo Assembly of the Pokeweed Genome Provides Insight Into Pokeweed Antiviral Protein (PAP) Gene Expression. [PDF]
Front Plant Sci, 2019 Ribosome-inactivating proteins (RIPs) are RNA glycosidases thought to function in defense against pathogens. These enzymes remove purine bases from RNAs, including rRNA; the latter activity decreases protein synthesis in vitro, which is hypothesized to limit pathogen proliferation by causing host cell death.
Neller KCM +3 more
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Homodimerization of pokeweed antiviral protein as a mechanism to limit depurination of pokeweed ribosomes. [PDF]
Mol Plant Pathol, 2010 SUMMARY Ribosome inactivating proteins are glycosidases synthesized by many plants and have been hypothesized to serve in defence against pathogens. These enzymes catalytically remove a conserved purine from the sarcin/ricin loop of the large ribosomal RNA, which has been shown in vitro
Tourlakis ME +4 more
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Pokeweed antiviral protein: its cytotoxicity mechanism and applications in plant disease resistance. [PDF]
Toxins (Basel), 2015 Pokeweed antiviral protein (PAP) is a 29 kDa type I ribosome inactivating protein (RIP) found in pokeweed plants. Pokeweed produces different forms of PAP. This review focuses on the spring form of PAP isolated from Phytolacca americana leaves. PAP exerts its cytotoxicity by removing a specific adenine from the α-sarcin/ricin loop of the large ...
Di R, Tumer NE.
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Poliovirus-mediated entry of pokeweed antiviral protein. [PDF]
Antimicrob Agents Chemother, 1990 Infection of HeLa cells with poliovirus results in cell permeabilization to pokeweed antiviral protein. Cell permeabilization was dependent on the integrity of virus capsid proteins and directly proportional to the multiplicity of infection. This study demonstrates that virus adsorption is sufficient for the entry of pokeweed antiviral protein into ...
Lee T +4 more
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Inhibition of hepatitis B virus replication by pokeweed antiviral protein in vitro. [PDF]
World J Gastroenterol, 2008 To explore the inhibitory effects of pokeweed antiviral protein seed (PAP-S) and PAP encoded by a eukaryotic expression plasmid on hepatitis B virus (HBV) replication in vitro.HepG2 2.2.15 cells in cultured medium were treated with different concentrations of PAP-S.
He YW, Guo CX, Pan YF, Peng C, Weng ZH.
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Extracellular localization of pokeweed antiviral protein. [PDF]
Proc Natl Acad Sci U S A, 1986 Pokeweed antiviral protein is an enzyme of Mr 29,000 known to inactivate a wide variety of eukaryotic ribosomes. We have used electron microscopy to show that the antibody specific for the protein is bound within the cell wall matrix of leaf mesophyll cells from Phytolacca americana. Any penetration or breakage of the cell wall and membrane could allow
Ready MP, Brown DT, Robertus JD.
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Suppression of human T-cell leukemia virus I gene expression by pokeweed antiviral protein. [PDF]
J Biol Chem, 2009 Human T-cell leukemia virus I (HTLV-I) is a deltaretrovirus that is the causative agent of adult T-cell leukemia and the neurological disorder HTLV-I-associated myelopathy/tropical spastic paraparesis. Currently, no effective antiretroviral treatment options are available to restrict the development of diseases associated with the virus.
Mansouri S +4 more
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Broad-spectrum virus resistance in transgenic plants expressing pokeweed antiviral protein. [PDF]
Proc Natl Acad Sci U S A, 1993 Exogenous application of pokeweed antiviral protein (PAP), a ribosome-inhibiting protein found in the cell walls of Phytolacca americana (pokeweed), protects heterologous plants from viral infection. A cDNA clone for PAP was isolated and introduced into tobacco and potato plants by transformation with Agrobacterium tumefaciens.
Lodge JK, Kaniewski WK, Tumer NE.
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