Results 121 to 130 of about 1,930 (169)

Redox-Epigenetic Crosstalk in Plant Stress Responses: The Roles of Reactive Oxygen and Nitrogen Species in Modulating Chromatin Dynamics. [PDF]

Int J Mol Sci
Kaya C, Adamakis IS.
europepmc   +1 more source

Virus Protein-Specific Immune Responses in Selective Depletion of Lymphocyte Populations Using Monoclonal Antibodies in Bolivian Squirrel Monkeys (<i>Saimiri boliviensis boliviensisv</i>). [PDF]

Viral Immunol
Nehete PN, Nehete BP, Chitta S.
europepmc   +1 more source

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Pokeweed antiviral protein inactivates pokeweed ribosomes; implications for the antiviral mechanism

The Plant Journal, 1994
Pokeweed antiviral protein (PAP) and other ribosome‐inactivating proteins (RIPs) had previously been thought to be incapable of attacking conspecific ribosomes, thus having no effect on endogenous processes. This assertion conflicts with a model for PAP’s in vivo antiviral mechanism in which PAP (a cell wall protein) selectively enters virus‐infected ...
M S, Bonness, M P, Ready, J D, Irvin, T J, Mabry   +3 more
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Pokeweed antiviral protein: a potential nonspermicidal prophylactic antiviral agent

Fertility and Sterility, 2001
To investigate the effects of pokeweed antiviral protein (PAP), a 29-kDa anti-human immunodeficiency virus (HIV) protein purified from the leaves of Phytolacca americana, on human sperm function.Prospective, controlled study.Reproductive biology department.Seven sperm donors.Human sperm and female genital tract epithelial cells were exposed to PAP ...
O J, D'Cruz, F M, Uckun
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Expression of pokeweed antiviral proteins in creeping bentgrass

Plant Cell Reports, 2003
Fungal diseases of creeping bentgrass, an important amenity grass used extensively on golf courses, are a serious problem in golf course management. Transgenic approaches to improving disease resistance to fungal diseases are being explored in many species, and in some cases ribosome-inactivating proteins have been found to be effective.
W D, Dai, S, Bonos, Z, Guo, W A, Meyer, P R, Day, F C, Belanger   +5 more
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Pokeweed antiviral protein: Ribosome inactivation and therapeutic applications

Pharmacology & Therapeutics, 1992
Pokeweed antiviral protein (PAP) is a ribosome-inactivating protein (RIP) that inactivates ribosomes by the removal of a single adenine from ribosomal RNA. The studies summarized in our review concern the nature and application of this novel therapeutic agent. We describe how researchers continue to elucidate the structure and biologic activity of RIPs.
J D, Irvin, F M, Uckun
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Requirements for antiribosomal activity of pokeweed antiviral protein

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1983
It has been known for some time that pokeweed antiviral protein acts by enzymatically inhibiting protein synthesis on eucaryotic ribosome systems. The site of this action is known to be the ribosome itself. In this paper we show that the pokeweed antiviral protein reaction against ribosomes is a strong function of salt concentrations, where 160 mM K ...
M, Ready, S, Bird, G, Rothe, J D, Robertus   +3 more
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The 2·5 Å Structure of Pokeweed Antiviral Protein

Journal of Molecular Biology, 1993
The pokeweed antiviral protein (PAP), isolated from the leaves of Phytolacca americana, is one of a family of plant and bacterial ribosome-inhibiting proteins (RIPs) which act as specific N-glycosidases on rRNA. Here we report the three-dimensional structure of PAP determined to 2.5 A resolution by X-ray crystallography.
A F, Monzingo, E J, Collins, S R, Ernst, J D, Irvin, J D, Robertus   +4 more
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Pokeweed Antiviral Protein and Its Applications

2000
The genus Phytolacca produces a number of proteins that have antiviral properties. These antiviral proteins are ribosome-inactivating proteins (RIPs) which remove a single adenine from a highly conserved, surface-exposed, stem-loop structure in the large rRNA of eukaryotic and prokaryotic ribosomes.
N E, Tumer, K, Hudak, R, Di, C, Coetzer, P, Wang, O, Zoubenko   +5 more
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A small RNA targets pokeweed antiviral protein transcript

Physiologia Plantarum, 2015
AbstractRibosome‐inactivating proteins (RIPs) are a class of plant defense proteins with N‐glycosidase activity (EC 3.2.2.22). Pokeweed antiviral protein (PAP) is a Type I RIP isolated from the pokeweed plant, Phytolacca americana, thought to confer broad‐spectrum virus resistance in this plant.
Alexander, Klenov, Kira C M, Neller, Lydia A, Burns, Gabriela, Krivdova, Katalin A, Hudak   +4 more
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