Results 131 to 140 of about 1,905 (165)
Actions of Pokeweed Antiviral Protein on Virus-infected Protoplasts [PDF]
Bioscience, Biotechnology and Biochemistry, 1997 Pokeweed antiviral protein (PAP) belongs to a group of ribosome-inactivating proteins (RIPs) that inactivate ribosomes by depurinating rRNA at a specific site. To study the mechanism for the antiviral activity of PAP, the actions of PAP on TMV-infected and uninfected tobacco protoplasts were investigated.
Keiichi Watanabe +2 more
exaly +3 more sources
Identification of a biological inactive complex form of pokeweed antiviral protein [PDF]
FEBS Letters, 1997 Pokeweed antiviral protein (PAP) inactivates both eukaryotic and prokaryotic ribosomes via a specific depurination of rRNA. The sensitivity of pokeweed ribosomes to PAP implies the existence of a mechanism to protect the plant. Using monoclonal antibodies specific to PAP, a protein complex (PAPi) which contained PAP was identified in leaf extract.
Benedicte Desvoyes +2 more
exaly +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Pokeweed antiviral protein inactivates pokeweed ribosomes; implications for the antiviral mechanism
The Plant Journal, 1994Pokeweed antiviral protein (PAP) and other ribosome‐inactivating proteins (RIPs) had previously been thought to be incapable of attacking conspecific ribosomes, thus having no effect on endogenous processes. This assertion conflicts with a model for PAP’s in vivo antiviral mechanism in which PAP (a cell wall protein) selectively enters virus‐infected ...
M S, Bonness +3 more
openaire +2 more sources
FEBS Letters, 1982 Pokeweed antiviral protein (PAP) is a protein known to inactivate eukaryotic ribosomes by an unknown enzymatic action and inhibit the production of mammalian viruses in tissue culture. This protein was subjected to a variety of chemical modifications to determine their effects upon ribosomal inactivation, antiviral action, and cytotoxicity.
James D Irvin
exaly +3 more sources
Expression of pokeweed antiviral proteins in creeping bentgrass
Plant Cell Reports, 2003Fungal diseases of creeping bentgrass, an important amenity grass used extensively on golf courses, are a serious problem in golf course management. Transgenic approaches to improving disease resistance to fungal diseases are being explored in many species, and in some cases ribosome-inactivating proteins have been found to be effective.
W D, Dai +5 more
openaire +2 more sources
Virus Research, 2013 Pokeweed antiviral protein (PAP) is a plant-derived N-glycosidase ribosomal-inactivating protein isolated from Phytolacca americana. The antiviral activity of PAP has been described in several viruses. This study was to investigate the antiviral activity of PAP against Japanese encephalitis virus (JEV) infection in vitro and in vivo. Antiviral activity
Hassan Z A Ishag, Chen Li, Bo Ni
exaly +3 more sources
The 2·5 Å Structure of Pokeweed Antiviral Protein
Journal of Molecular Biology, 1993The pokeweed antiviral protein (PAP), isolated from the leaves of Phytolacca americana, is one of a family of plant and bacterial ribosome-inhibiting proteins (RIPs) which act as specific N-glycosidases on rRNA. Here we report the three-dimensional structure of PAP determined to 2.5 A resolution by X-ray crystallography.
A F, Monzingo +4 more
openaire +2 more sources
Pokeweed Antiviral Protein and Its Applications
2000The genus Phytolacca produces a number of proteins that have antiviral properties. These antiviral proteins are ribosome-inactivating proteins (RIPs) which remove a single adenine from a highly conserved, surface-exposed, stem-loop structure in the large rRNA of eukaryotic and prokaryotic ribosomes.
N E, Tumer +5 more
openaire +2 more sources
Pokeweed antiviral protein: Ribosome inactivation and therapeutic applications
Pharmacology & Therapeutics, 1992Pokeweed antiviral protein (PAP) is a ribosome-inactivating protein (RIP) that inactivates ribosomes by the removal of a single adenine from ribosomal RNA. The studies summarized in our review concern the nature and application of this novel therapeutic agent. We describe how researchers continue to elucidate the structure and biologic activity of RIPs.
J D, Irvin, F M, Uckun
openaire +2 more sources
Isolation and analysis of a genomic clone encoding a pokeweed antiviral protein
Plant Molecular Biology, 1992Partial cDNAs encoding a pokeweed antiviral protein were obtained by polymerase chain reaction from the poly(A)+ RNA of seeds, leaves, and roots using two specific primers based on the amino acid sequence of a pokeweed antiviral protein from the seeds (PAP-S).
J, Kataoka +4 more
openaire +2 more sources