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Mucosal Toxicity Studies of a Gel Formulation of Native Pokeweed Antiviral Protein
Toxicologic Pathology, 2004Pokeweed antiviral protein (PAP), a 29-kDa plant-derived protein isolated from Phytolacca americana, is a promising nonspermicidal broad-spectrum antiviral microbicide. This study evaluated the mucosal toxicity potential of native PAP in the in vivo rabbit vaginal irritation model as well as the in vitro reconstituted human vaginal epithelial tissue ...
Osmond J, D'Cruz +2 more
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International Journal of Immunopharmacology, 1983
The immunological activity of Momordica Charantia inhibitor (MCI) and of Pokeweed antiviral protein (PAP-S), 30,000 daltons plant proteins possessing close similarity to Ricin A chain as inhibitor of protein synthesis, was investigated in mice. In vivo, single nontoxic injections of microgram amount of these substances delayed H2-incompatible skin ...
F, Spreafico +7 more
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The immunological activity of Momordica Charantia inhibitor (MCI) and of Pokeweed antiviral protein (PAP-S), 30,000 daltons plant proteins possessing close similarity to Ricin A chain as inhibitor of protein synthesis, was investigated in mice. In vivo, single nontoxic injections of microgram amount of these substances delayed H2-incompatible skin ...
F, Spreafico +7 more
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A 13-week subchronic intravaginal toxicity study of Pokeweed antiviral protein in mice
Phytomedicine, 2004Pokeweed antiviral protein (PAP), a 29-kDa plant-derived protein isolated from Phytolacca americana, is a broad-spectrum antiviral agent. PAP shows unique clinical potential to become the active ingredient of a non-spermicidal microbicide because of its potent in vivo anti-HIV activity, non-interference with in vivo sperm functions, and lack of ...
O J, D'Cruz, B, Waurzyniakt, F M, Uckun
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Plant resistance to fungal infection induced by nontoxic pokeweed antiviral protein mutants
Nature Biotechnology, 1997Pokeweed antiviral protein (PAP), a 29-kD protein isolated from Phytolacca americana inhibits translation by catalytically removing a specific adenine residue from the large rRNA of the 60S subunit of eukaryotic ribosomes. Transgenic plants expressing PAP are resistant to a broad spectrum of plant viruses.
O, Zoubenko +4 more
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High-Level Expression and Purification of Biologically Active Recombinant Pokeweed Antiviral Protein
Protein Expression and Purification, 1999Pokeweed antiviral protein (PAP) from the leaves of the pokeweed plant, Phytolacca americana, is a naturally occurring single-chain ribosome-inactivating protein, which catalytically inactivates both prokaryotic and eukaryotic ribosomes. The therapeutic potential of PAP has gained considerable interest in recent years due to the clinical use of native ...
F, Rajamohan +5 more
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Pokeweed Antiviral Protein as an Universal Virus Neutralizer
2002Abstract : The objective of this project is to develop strategies which will allow the use of recombinant mutant pokeweed antiviral protein (PAP) as a potential countermeasure against biological warfare attempts employing pathogenic viruses. In order to increase the therapeutic index of the naturally occurring PAP, recombinant PAP mutants with superior
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Production of pokeweed antiviral proteins nontoxic to cells by Mutagenesis of PAP-cDNA
Journal of Plant Biology, 1998Pokeweed antiviral protein (PAP), one of ribosome inactivating proteins (RIPs), has very strong toxicity both to prokaryotic and eukaryotic cells. To produce mutant PAPs nontoxic to cells, the PAP-cDNA was inserted into a yeast-E.coli shuttle vector under the control of galactose promoter, mutagenized using hydroxylamine, and transformed into yeast ...
Yoonkang Hur +2 more
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