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Biological activity of ribosome-inactivating proteins from Malus domestica (apple) and Sambucus nigra (elderberry) [PDF]
, 2015 Shang, Chenjing
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Ehtnobotanical- And Chemometric-Guided Investigation Of Phytolacca Americana L. [PDF]
, 2015 Chan, Michael
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Japanese encephlu emergence in Australia: the potential population at risk. [PDF]
Ann Med Surg (Lond)Khan A +6 more
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Requirements for antiribosomal activity of pokeweed antiviral protein
Biochimica Et Biophysica Acta Gene Regulatory Mechanisms, 1983It has been known for some time that pokeweed antiviral protein acts by enzymatically inhibiting protein synthesis on eucaryotic ribosome systems. The site of this action is known to be the ribosome itself. In this paper we show that the pokeweed antiviral protein reaction against ribosomes is a strong function of salt concentrations, where 160 mM K ...
Jon D Robertus
exaly +3 more sources
Pokeweed antiviral protein: a potential nonspermicidal prophylactic antiviral agent
Fertility and Sterility, 2001To investigate the effects of pokeweed antiviral protein (PAP), a 29-kDa anti-human immunodeficiency virus (HIV) protein purified from the leaves of Phytolacca americana, on human sperm function.Prospective, controlled study.Reproductive biology department.Seven sperm donors.Human sperm and female genital tract epithelial cells were exposed to PAP ...
Osmond J D'Cruz
exaly +3 more sources
Depurination of plant ribosomes by pokeweed antiviral protein [PDF]
FEBS Letters, 1990 Mammalian ribosomes have been shown to be enzymatically modified by ribosomal inactivating protein (RIPs) via specific depurination of rRNA. Here we report that ribosomes isolated from wheat germ contain intact and undepurinated rRNA and are depurinated by pokeweed antiviral protein (PAP).
James D Irvin
exaly +3 more sources
A possible mechanism for the antiviral activity of pokeweed antiviral protein
Physiological and Molecular Plant Pathology, 1993Abstract The mechanism by which pokeweed antiviral protein (PAP) inhibits the infection of tobacco by TMV was investigated. The N-glycosidase activity of PAP was measured using a combination of aniline treatment to cleave the rRNA at the depurinated site, gel electrophoresis and Northern blot hybridization using a probe specific for the 3′ end of ...
J F Antoniw
exaly +2 more sources
Reversal of the inhibitory effects of the pokeweed antiviral protein upon protein synthesis
Nucleic Acids and Protein Synthesis, 1981Protein synthesis directed by natural mRNA is more sensitive to the inhibitory action of the pokeweed antiviral protein than synthesis directed by poly-(uridylic acid). Investigations into the nature of this difference revealed that pokeweed antiviral protein does not inhibit the initiation stage of protein synthesis and that the expression of pokeweed
James D Irvin
exaly +3 more sources