Results 141 to 150 of about 1,930 (169)
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A 13-week subchronic intravaginal toxicity study of Pokeweed antiviral protein in mice
Phytomedicine, 2004Pokeweed antiviral protein (PAP), a 29-kDa plant-derived protein isolated from Phytolacca americana, is a broad-spectrum antiviral agent. PAP shows unique clinical potential to become the active ingredient of a non-spermicidal microbicide because of its potent in vivo anti-HIV activity, non-interference with in vivo sperm functions, and lack of ...
O J, D'Cruz, B, Waurzyniakt, F M, Uckun
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Crystal structure of pokeweed antiviral protein from seeds ofPhytolacca americana at 0.25 nm
Science in China Series C: Life Sciences, 1998Crystals of pokeweed antiviral protein (PAP) from seeds ofPhytolacca americana with high diffraction ability were grown from high protein concentration (100 mg/mL) solution at high temperature (33 degrees C). The crystal structure was solved by use of molecular replacement method and refied by use of molecular dynamic method at 0.25 nm to anR factor of
Z, Zeng, L, Jin, H, Li, Z, Hu, D, Wang
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Deguanylation of Human Immunodeficiency Virus (HIV-1) RNA by Recombinant Pokeweed Antiviral Protein
Biochemical and Biophysical Research Communications, 1999Modeling studies, combined with the molecular docking of the trinucleotide GGG into the active site of the deadenylating RNA N-glycosidase pokeweed antiviral protein (PAP), indicated that a guanine base can fit into the active site pocket of PAP without disturbing its unique geometry and is sandwiched between residues Tyr(72) and Tyr(123) very much ...
F, Rajamohan +3 more
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Protein Expression and Purification, 2000
Pokeweed antiviral protein (PAP)-I from the spring leaves of Phytolacca americana is a naturally occurring RNA-depurinating enzyme with broad-spectrum antiviral activity. Interest in PAP is growing due to its use as a potential anti-HIV agent. However, the clinical use of native PAP is limited due to inherent difficulties in obtaining sufficient ...
F, Rajamohan +5 more
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Pokeweed antiviral protein (PAP)-I from the spring leaves of Phytolacca americana is a naturally occurring RNA-depurinating enzyme with broad-spectrum antiviral activity. Interest in PAP is growing due to its use as a potential anti-HIV agent. However, the clinical use of native PAP is limited due to inherent difficulties in obtaining sufficient ...
F, Rajamohan +5 more
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International Journal of Immunopharmacology, 1983
The immunological activity of Momordica Charantia inhibitor (MCI) and of Pokeweed antiviral protein (PAP-S), 30,000 daltons plant proteins possessing close similarity to Ricin A chain as inhibitor of protein synthesis, was investigated in mice. In vivo, single nontoxic injections of microgram amount of these substances delayed H2-incompatible skin ...
F, Spreafico +7 more
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The immunological activity of Momordica Charantia inhibitor (MCI) and of Pokeweed antiviral protein (PAP-S), 30,000 daltons plant proteins possessing close similarity to Ricin A chain as inhibitor of protein synthesis, was investigated in mice. In vivo, single nontoxic injections of microgram amount of these substances delayed H2-incompatible skin ...
F, Spreafico +7 more
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High resolution X-ray structure of potent anti-HIV pokeweed antiviral protein-III
Biochemical Pharmacology, 2003Pokeweed antiviral protein III (PAP-III), a naturally occurring protein isolated from late summer leaves of the pokeweed plant (Phytolacca americana), has potent anti-HIV activity by an as yet undetermined molecular mechanism. PAP-III belongs to a family of ribosome-inactivating proteins that catalytically deadenylate ribosomal and viral RNA.
Igor V, Kurinov, Fatih M, Uckun
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Pokeweed Antiviral Protein as an Universal Virus Neutralizer
2002Abstract : The objective of this project is to develop strategies which will allow the use of recombinant mutant pokeweed antiviral protein (PAP) as a potential countermeasure against biological warfare attempts employing pathogenic viruses. In order to increase the therapeutic index of the naturally occurring PAP, recombinant PAP mutants with superior
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Interactions Between Tobacco Mosaic Virus, Pokeweed Antiviral Proteins, and Tobacco Cell Wall
Phytopathology, 1990(...) The antiviral proteins adsorbed to the cell wall in 0-200 mM KCl solution, but did not adsorb in 300 mM KCl. However, since the formation of TMV local lesions on Nicotiana glutinosa was inhibited by the antiviral proteins in 300 mM KCl (where the conjugation between TMV and the antiviral proteins and the adsorption of the antiviral proteins on ...
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The contemporary management of cancers of the sinonasal tract in adults
Ca-A Cancer Journal for Clinicians, 2023Rajat Thawani
exaly