Results 71 to 80 of about 466,499 (265)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

What does the fox say? Arctic fox vocalization and associated den behaviours

Polar Research
Foxes (Vulpes spp.) are small, solitary canids with relatively low social complexity compared to more gregarious canids, such as wolves and dogs. They are, therefore, expected to have a relatively simple vocal repertoire, with limited low-intensity ...
Kayla J. Buhler, Gustaf Samelius, Ray Alisauskas, Emily Jenkins   +3 more
doaj   +1 more source

Les femmes et le polar italien. Les trois romans policiers de Nicoletta Vallorani

Italies, 1999
Dès ses trois premiers romans, Nicoletta Vallorani (née en 1959) se consacre sciemment à la révision des règles du roman policier et à sa contamination, convaincue que « la littérature de genre offre la plus grande liberté de détruire les règles, d ...
Claudio Milanesi
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Apuntes sobre mestizaje e hibridez: los riesgos de la metáfora

Kipus: Revista Andina de Letras y Estudios Culturales
Archivo histórico de Kipus: Revista Andina de Letras y Estudios Culturales, 1997. Esta información es parte del repositorio institucional UASB-Digital, de la Universidad Andina Simón Bolívar, Sede Ecuador.
Antonio Cornejo Polar
doaj  

« Bon flic » : quelques éléments sur l’image de la police dans le polar français contemporain

Belphégor
L’intérêt de la critique littéraire pour le roman noir fait parfois oublier que le polar est aussi, historiquement, une littérature de police. À l’heure où la question policière nourrit mécontentements et débats en France, où les conditions d’une police ...
Lucie Amir
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Le Paris des Aventures extraordinaires d’Adèle Blanc-Sec de Jacques Tardi

Géographie et Cultures, 2007
Piece of art, space and society are here approached in a relational perspective which focuses on the links they entertain. More precisely, the question of the city representation in the comic-book concerns geography insomuch as this artistic genre ...
Géraldine Molina
doaj   +1 more source