Results 61 to 70 of about 49,266 (284)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Spatial Heat Transport, Polar Amplification and Climate Change Policy [PDF]
, 2017 This paper is, to our knowledge, the first paper in climate economics to consider the combination of spatial heat transport and polar amplification. We simplified the problem by stratifying the Earth into latitude belts and assuming, as in North et al ...
Brock, W., Xepapadeas, A.
core +1 more source
Geophysical Research Letters, 2023 Arctic amplification has been proposed to promote temperature extremes by slowing the midlatitude jet and increasing the amplitude of its meanders. Observational and modeling studies have used a variety of metrics to quantify jet waviness.
Ruth Geen +7 more
doaj +1 more source
Polarization-Independent Phase-Sensitive Amplification
Journal of Lightwave Technology, 2016 We thoroughly analyze the requirements on the signal and idler state of polarizations (SOPs) for achieving maximum amplification in phase-sensitive amplifiers (PSAs). These requirements are described using a Jones-space description as well as a Stokes-space description.
Lorences-Riesgo, Abel +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses [PDF]
Journal of Clinical Investigation, 2001 Fractalkine (FKN, CX3CL1) is a membrane-bound CX3C chemokine induced by primary proinflammatory signals in vascular endothelial cells (ECs). Here we examined the role of FKN in polarized Th1 or Th2 responses. Proinflammatory signals, including LPS, IL-1, TNF, and CD40 ligand, induced FKN, as did IFN-gamma, which had synergistic activity with TNF.
Paolo Fraticelli +12 more
openaire +4 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Revisiting the mass balance of Bennett Island glaciation, East Siberian Sea
Arctic, Antarctic, and Alpine ResearchBennett Island is located between the East Siberian Sea and the Arctic Ocean and is part of the De Long archipelago, which is the easternmost location in the high Arctic where terrestrial glaciation exists.
Anton Viktorovich Terekhov +5 more
doaj +1 more source
The Effect of Arctic Sea‐Ice Loss on Extratropical Cyclones
Geophysical Research Letters, 2023 Taking advantage of the Polar Amplification Model Intercomparison Project simulations and using a Lagrangian objective feature tracking algorithm, we determine the response of extratropical cyclones to sea‐ice loss and consequent weakening of the equator‐
Stephanie Hay +4 more
doaj +1 more source