Results 81 to 90 of about 49,266 (284)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Warm Arctic—cold continents: climate impacts of the newly open Arctic Sea

, 2011
Recent Arctic changes are likely due to coupled Arctic amplification mechanisms with increased linkage between Arctic climate and sub-Arctic weather. Historically, sea ice grew rapidly in autumn, a strong negative radiative feedback.
Wood, Kevin R., Overland, James E., Wang, Muyin, James E. Overland, Muyin Wang, Kevin R. Wood   +5 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The Polar Stratosphere as an Arbiter of the Projected Tropical Versus Polar Tug of War

Geophysical Research Letters, 2019
This study explores the “tug of war” between the effects of Arctic amplification (“AA”) and upper‐troposphere tropical warming (“UTW”) on the response of the future North Atlantic atmospheric circulation.
Yannick Peings, Julien Cattiaux, Gudrun Magnusdottir   +2 more
doaj   +1 more source

Cyclotron amplification of whistler-mode waves: a parametric study relevant to discrete VLF emissions in the earth's magnetosphere

, 2002
We study the non linear amplification of VLF waves in the earth's magnetosphere. Particular attention is paid to zero order distribution functions of electrons in which there is a sharp step with respect to parallel velocity.
Nunn, D, Demekhov, AG, Rycroft, MJ, Trakhtengerts, VY, Pasmanik, DL   +4 more
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Contrasting Anthropogenic Drivers Behind Asymmetric Warming in the Arctic and Antarctica

Ocean-Land-Atmosphere Research
Surface air temperature (SAT) in polar regions is rising faster than the global average. This study analyzes the rapid increase in anthropogenic influences throughout the industrial period on Arctic and Antarctic warming, utilizing climate models.
Basudev Swain, Marco Vountas, Aishwarya Singh, Upasana Panda, Rui Song, Nidhi L. Anchan, Chakradhar Reddy Malasani, Dukhishyam Mallick, Richard Alawode, Adrien Deroubaix, Luca Lelli, Julia Schmale, Ankit Tandon, Sachin S. Gunthe, Manfred Wendisch, Vittal Hari, Hartmut Bösch   +16 more
doaj   +1 more source

Code and data for 'Decomposing the drivers of polar amplification'

, 2020
<p>Code and data related to 'Decomposing the drivers of polar amplification using a single column model'.</p> <p>Use plot_figures.ipynb python notebook to make Main figures, SI figures and table data.</p ...
Matthew Henry
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Global Coupled Climate Response to Polar Sea Ice Loss: Evaluating the Effectiveness of Different Ice‐Constraining Approaches

Geophysical Research Letters, 2020
Coupled ocean‐atmosphere models have been utilized to investigate the global climate response to polar sea ice loss using different approaches to constrain ice concentration and thickness.
Lantao Sun, Clara Deser, Robert A. Tomas, Michael Alexander   +3 more
doaj   +1 more source