Results 71 to 80 of about 49,266 (284)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Recent Advancements in N-polar GaN HEMT Technology

Crystals
N-polar GaN HEMT technology has emerged as a disruptive technology that outperforms Ga-polar GaN HEMTs in terms of high-frequency power amplification capability.
Emre Akso, Kamruzzaman Khan, Henry Collins, Boyu Wang, Robert Hamwey, Tanmay Chavan, Christopher Clymore, Weiyi Li, Oguz Odabasi, Matthew Guidry, Stacia Keller, Elaheh Ahmadi, Steven P. DenBaars, Umesh Mishra   +13 more
doaj   +1 more source

The interaction between the stratosphere and the troposphere as revealed by singular vectors

Meteorologische Zeitschrift, 2007
Stratospheric singular vectors (S-SV's) have been calculated with one of the latest versions of the ECMWF model, for the months January and July 2004-2006.
Jan-Otto Hooghoudt, Jan Barkmeijer
doaj   +1 more source

Biodiversity and distribution of polar freshwater DNA viruses

, 2015
Viruses constitute the most abundant biological entities and a large reservoir of genetic diversity on Earth. Despite the recent surge in their study, our knowledge on their actual biodiversity and distribution remains sparse.
López-Bueno, Alberto, Pearce, David, Pearce, David A., Alcamí, Antonio, Aguirre de Cárcer, Daniel   +4 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Amplification of the entire mitochondrial genome from polar body obtained by the amplification of 46 overlapping fragments using MitoAll kit.

, 2014
Amplification of the entire mitochondrial genome from polar body obtained by the amplification of 46 overlapping fragments using MitoAll kit.
Donata Luiselli (414847), Anna Pia Ferraretti (599833), Luca Gianoarli (599830), Giovanni Romeo (19382), M. Cristina Magli (599835), Anna Maria Crivello (599831), Martin Lang (599832), Sara De Fanti (599834)   +7 more
core   +1 more source

Can Polar Stratospheric Clouds Explain Arctic Amplification?

, 2023
Climate models underestimate the magnitude of Arctic warming in past warm climates, like the early Cretaceous and Paleogene periods, implying that certain physical processes might be missing or poorly represented.
Gupta, AS ; https://orcid.org/, Dutta, D ; https://orcid.org/, Sherwood, SC ; https://orcid.org/, Jucker, M ; https://orcid.org/, Meissner, KJ ; https://orcid.org/   +4 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Exploring the Timescales and Mechanisms of Polar Amplification

, 2023
Polar amplification (PA), defined as the enhanced warming of the polar region relative to the global average, is a robust feature of historical observations and simulations of future climate. Because PA has yet to be realized in the Antarctic, I mainly focus on Arctic amplification (AA).
openaire   +2 more sources